Knee osteoarthritis and menopausal hormone therapy in postmenopausal women: a nationwide cross-sectional study

Jae Hyun Jung, Cho Hee Bang, Gwan Gyu Song, Cholhee Kim, Jae Hoon Kim, Sungjae Choi

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)

    Abstract

    OBJECTIVE: The incidence of osteoarthritis (OA) increases after menopause, and may be related to hormonal changes in women. Estrogen deficiency is known to affect the development of OA, and menopausal hormone therapy (MHT) is suggested to be related to the development of OA. However, the relationship between knee OA and MHT remains controversial. The association between knee OA prevalence and MHT was investigated using large-scale national data. METHODS: Data were collected from 4,766 postmenopausal women from the Korea National Health and Nutrition Examination Survey (2009-2012). MHT was defined as regular hormone medication for ≥1 year, and demographic and lifestyle variables were compared between the MHT and non-MHT groups. Knee OA was defined according to symptoms and radiographic findings. RESULTS: In the multiple logistic regression models, the OA odds ratio was 0.70 for the MHT group (95% confidence interval 0.50-0.99), compared with the non-MHT group. CONCLUSIONS: The prevalence of knee OA was lower in participants with MHT than in those without MHT.

    Original languageEnglish
    Pages (from-to)598-602
    Number of pages5
    JournalMenopause (New York, N.Y.)
    Volume26
    Issue number6
    DOIs
    Publication statusPublished - 2018 Dec 21

    ASJC Scopus subject areas

    • Obstetrics and Gynaecology

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