Knee osteoarthritis and menopausal hormone therapy in postmenopausal women: a nationwide cross-sectional study

Jae Hyun Jung, Cho Hee Bang, Gwan Gyu Song, Cholhee Kim, Jae Hoon Kim, Sungjae Choi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

OBJECTIVE: The incidence of osteoarthritis (OA) increases after menopause, and may be related to hormonal changes in women. Estrogen deficiency is known to affect the development of OA, and menopausal hormone therapy (MHT) is suggested to be related to the development of OA. However, the relationship between knee OA and MHT remains controversial. The association between knee OA prevalence and MHT was investigated using large-scale national data. METHODS: Data were collected from 4,766 postmenopausal women from the Korea National Health and Nutrition Examination Survey (2009-2012). MHT was defined as regular hormone medication for ≥1 year, and demographic and lifestyle variables were compared between the MHT and non-MHT groups. Knee OA was defined according to symptoms and radiographic findings. RESULTS: In the multiple logistic regression models, the OA odds ratio was 0.70 for the MHT group (95% confidence interval 0.50-0.99), compared with the non-MHT group. CONCLUSIONS: The prevalence of knee OA was lower in participants with MHT than in those without MHT.

Original languageEnglish
Pages (from-to)598-602
Number of pages5
JournalMenopause (New York, N.Y.)
Volume26
Issue number6
DOIs
Publication statusPublished - 2018 Dec 21

Fingerprint

Knee Osteoarthritis
Cross-Sectional Studies
Hormones
Osteoarthritis
Group Psychotherapy
Therapeutics
Logistic Models
Nutrition Surveys
Korea
Menopause
Life Style
Estrogens
Odds Ratio
Demography
Confidence Intervals

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Knee osteoarthritis and menopausal hormone therapy in postmenopausal women : a nationwide cross-sectional study. / Jung, Jae Hyun; Bang, Cho Hee; Song, Gwan Gyu; Kim, Cholhee; Kim, Jae Hoon; Choi, Sungjae.

In: Menopause (New York, N.Y.), Vol. 26, No. 6, 21.12.2018, p. 598-602.

Research output: Contribution to journalArticle

@article{7ee3a6fd13584343a84648f869ca0932,
title = "Knee osteoarthritis and menopausal hormone therapy in postmenopausal women: a nationwide cross-sectional study",
abstract = "OBJECTIVE: The incidence of osteoarthritis (OA) increases after menopause, and may be related to hormonal changes in women. Estrogen deficiency is known to affect the development of OA, and menopausal hormone therapy (MHT) is suggested to be related to the development of OA. However, the relationship between knee OA and MHT remains controversial. The association between knee OA prevalence and MHT was investigated using large-scale national data. METHODS: Data were collected from 4,766 postmenopausal women from the Korea National Health and Nutrition Examination Survey (2009-2012). MHT was defined as regular hormone medication for ≥1 year, and demographic and lifestyle variables were compared between the MHT and non-MHT groups. Knee OA was defined according to symptoms and radiographic findings. RESULTS: In the multiple logistic regression models, the OA odds ratio was 0.70 for the MHT group (95{\%} confidence interval 0.50-0.99), compared with the non-MHT group. CONCLUSIONS: The prevalence of knee OA was lower in participants with MHT than in those without MHT.",
author = "Jung, {Jae Hyun} and Bang, {Cho Hee} and Song, {Gwan Gyu} and Cholhee Kim and Kim, {Jae Hoon} and Sungjae Choi",
year = "2018",
month = "12",
day = "21",
doi = "10.1097/GME.0000000000001280",
language = "English",
volume = "26",
pages = "598--602",
journal = "Menopause",
issn = "1072-3714",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Knee osteoarthritis and menopausal hormone therapy in postmenopausal women

T2 - a nationwide cross-sectional study

AU - Jung, Jae Hyun

AU - Bang, Cho Hee

AU - Song, Gwan Gyu

AU - Kim, Cholhee

AU - Kim, Jae Hoon

AU - Choi, Sungjae

PY - 2018/12/21

Y1 - 2018/12/21

N2 - OBJECTIVE: The incidence of osteoarthritis (OA) increases after menopause, and may be related to hormonal changes in women. Estrogen deficiency is known to affect the development of OA, and menopausal hormone therapy (MHT) is suggested to be related to the development of OA. However, the relationship between knee OA and MHT remains controversial. The association between knee OA prevalence and MHT was investigated using large-scale national data. METHODS: Data were collected from 4,766 postmenopausal women from the Korea National Health and Nutrition Examination Survey (2009-2012). MHT was defined as regular hormone medication for ≥1 year, and demographic and lifestyle variables were compared between the MHT and non-MHT groups. Knee OA was defined according to symptoms and radiographic findings. RESULTS: In the multiple logistic regression models, the OA odds ratio was 0.70 for the MHT group (95% confidence interval 0.50-0.99), compared with the non-MHT group. CONCLUSIONS: The prevalence of knee OA was lower in participants with MHT than in those without MHT.

AB - OBJECTIVE: The incidence of osteoarthritis (OA) increases after menopause, and may be related to hormonal changes in women. Estrogen deficiency is known to affect the development of OA, and menopausal hormone therapy (MHT) is suggested to be related to the development of OA. However, the relationship between knee OA and MHT remains controversial. The association between knee OA prevalence and MHT was investigated using large-scale national data. METHODS: Data were collected from 4,766 postmenopausal women from the Korea National Health and Nutrition Examination Survey (2009-2012). MHT was defined as regular hormone medication for ≥1 year, and demographic and lifestyle variables were compared between the MHT and non-MHT groups. Knee OA was defined according to symptoms and radiographic findings. RESULTS: In the multiple logistic regression models, the OA odds ratio was 0.70 for the MHT group (95% confidence interval 0.50-0.99), compared with the non-MHT group. CONCLUSIONS: The prevalence of knee OA was lower in participants with MHT than in those without MHT.

UR - http://www.scopus.com/inward/record.url?scp=85066923940&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85066923940&partnerID=8YFLogxK

U2 - 10.1097/GME.0000000000001280

DO - 10.1097/GME.0000000000001280

M3 - Article

C2 - 30586007

AN - SCOPUS:85066923940

VL - 26

SP - 598

EP - 602

JO - Menopause

JF - Menopause

SN - 1072-3714

IS - 6

ER -