Korean guidelines for the diagnosis and management of dry eye: development and validation of clinical efficacy

Korean Corneal Disease Study Group

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

PURPOSE: To evaluate the clinical efficacy of newly developed guidelines for the diagnosis and management of dry eye.

METHODS: This retrospective, multi-center, non-randomized, observational study included a total of 1,612 patients with dry eye disease who initially visited the clinics from March 2010 to August 2010. Korean guidelines for the diagnosis and management of dry eye were newly developed from concise, expert-consensus recommendations. Severity levels at initial and final visits were determined using the guidelines in patients with 90 ± 7 days of follow-up visits (n = 526). Groups with different clinical outcomes were compared with respect to clinical parameters, treatment modalities, and guideline compliance. Main outcome measures were ocular and visual symptoms, ocular surface disease index, global assessment by patient and physician, tear film break-up time, Schirmer-1 test score, ocular surface staining score at initial and final visits, clinical outcome after three months of treatment, and guideline compliance.

RESULTS: Severity level was reduced in 47.37% of patients treated as recommended by the guidelines. Younger age (odd ratio [OR], 0.984; p = 0.044), higher severity level at initial visit, compliance to treatment recommendation (OR, 1.832; p = 0.047), and use of topical cyclosporine (OR, 1.838; p = 0.011) were significantly associated with improved clinical outcomes.

CONCLUSIONS: Korean guidelines for the diagnosis and management of dry eye can be used as a valid and effective tool for the treatment of dry eye disease.

Original languageEnglish
Pages (from-to)197-206
Number of pages10
JournalKorean journal of ophthalmology : KJO
Volume28
Issue number3
DOIs
Publication statusPublished - 2014 Jun 1
Externally publishedYes

Fingerprint

Guidelines
Eye Diseases
Odds Ratio
Compliance
Therapeutics
Tears
Cyclosporine
Observational Studies
Outcome Assessment (Health Care)
Staining and Labeling
Physicians

Keywords

  • Dry eye syndrome
  • Practice guideline
  • Standards

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Korean guidelines for the diagnosis and management of dry eye : development and validation of clinical efficacy. / Korean Corneal Disease Study Group.

In: Korean journal of ophthalmology : KJO, Vol. 28, No. 3, 01.06.2014, p. 197-206.

Research output: Contribution to journalArticle

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abstract = "PURPOSE: To evaluate the clinical efficacy of newly developed guidelines for the diagnosis and management of dry eye.METHODS: This retrospective, multi-center, non-randomized, observational study included a total of 1,612 patients with dry eye disease who initially visited the clinics from March 2010 to August 2010. Korean guidelines for the diagnosis and management of dry eye were newly developed from concise, expert-consensus recommendations. Severity levels at initial and final visits were determined using the guidelines in patients with 90 ± 7 days of follow-up visits (n = 526). Groups with different clinical outcomes were compared with respect to clinical parameters, treatment modalities, and guideline compliance. Main outcome measures were ocular and visual symptoms, ocular surface disease index, global assessment by patient and physician, tear film break-up time, Schirmer-1 test score, ocular surface staining score at initial and final visits, clinical outcome after three months of treatment, and guideline compliance.RESULTS: Severity level was reduced in 47.37{\%} of patients treated as recommended by the guidelines. Younger age (odd ratio [OR], 0.984; p = 0.044), higher severity level at initial visit, compliance to treatment recommendation (OR, 1.832; p = 0.047), and use of topical cyclosporine (OR, 1.838; p = 0.011) were significantly associated with improved clinical outcomes.CONCLUSIONS: Korean guidelines for the diagnosis and management of dry eye can be used as a valid and effective tool for the treatment of dry eye disease.",
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