Korean nomogram for the prediction of recurrence-free survival after definitive surgery for renal cell carcinoma

Cheryn Song, Jong Yeon Park, Moo Song Lee, Han Chung, Yong Hyun Cho, Bup Wan Kim, Sung Goo Chang, Chun Il Kim, Jun Cheon, Kyung Seop Lee, Se Il Chung, Moon Kee Chung, Han Yong Choi, Hyun Moo Lee, Se Joong Kim, Sung Joon Hong, Jae Il Chung, Sang Min Yoon, Yong Goo Lee, Hyung Jin KimHongsik Kim, Wun Jae Kim, Soo Bang Ryu, Hanjong Ahn, Choung Soo Kim

Research output: Contribution to journalArticle

Abstract

Purpose: This multiinstitutional study was to investigate the accuracy of the Kattan nomograms for the prediction of recurrence after definitive surgery for renal cell carcinoma (RCC) in Korean patients and develop a nomogram revised to complement the shortcomings. Materials and Methods: Clinical and pathological data of 1,866 patients with RCC who had been followed for at least 2 years after surgery in each participating institutes were reviewed as well as evidence of disease recurrence, defined to include local recurrence and distant metastasis. Accuracy of the Kattan nomograms' predictability in tumors 7cm or less was tested by calculating the area under the receiver-operating characteristics curve (AUC) and actuarial recurrence-free survival by Kaplan-Meier method. We used the Cox proportional hazard analysis to identify significant variables and develop prediction nomogram, and internally validated by bootstrapping method. Mean follow-up was 56.5 months (24-184). Results: Recurrence occurred in 12.5% of the patients and correlated with the pathological stage, with 4.3%, 7.9%, 15.0%, 22.6%, 38.4%, 58.3% for stages T1a, T1b, T2, T3a, T3b/c and T4, respectively (p<0.001). The AUC of the Kattan nomograms was 0.276. Factors significantly predictive of recurrence were T stage (p<0.0001), presentation (p=0.006), preoperative hemoglobin (p=0.023) and gender (p=0.032). Actuarial 60-month recurrence-free survival was 87.9% and using the prognostic factors, nomogram predicting 60-month recurrence-free survival was constructed. Conclusions: Korean nomogram complementing the preexisting nomograms for the prediction of recurrence-free survival after definitive surgery for RCC has been constructed, which may be useful in patient prognostication, counseling and follow-up planning.

Original languageEnglish
Pages (from-to)963-967
Number of pages5
JournalKorean Journal of Urology
Volume47
Issue number9
Publication statusPublished - 2006 Sep 1

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Nomograms
Renal Cell Carcinoma
Recurrence
Survival
Area Under Curve
ROC Curve
Counseling
Hemoglobins
Neoplasm Metastasis

Keywords

  • Nomograms
  • Renal neoplasm
  • Survival, disease free

ASJC Scopus subject areas

  • Urology

Cite this

Song, C., Park, J. Y., Lee, M. S., Chung, H., Cho, Y. H., Kim, B. W., ... Kim, C. S. (2006). Korean nomogram for the prediction of recurrence-free survival after definitive surgery for renal cell carcinoma. Korean Journal of Urology, 47(9), 963-967.

Korean nomogram for the prediction of recurrence-free survival after definitive surgery for renal cell carcinoma. / Song, Cheryn; Park, Jong Yeon; Lee, Moo Song; Chung, Han; Cho, Yong Hyun; Kim, Bup Wan; Chang, Sung Goo; Kim, Chun Il; Cheon, Jun; Lee, Kyung Seop; Chung, Se Il; Chung, Moon Kee; Choi, Han Yong; Lee, Hyun Moo; Kim, Se Joong; Hong, Sung Joon; Chung, Jae Il; Yoon, Sang Min; Lee, Yong Goo; Kim, Hyung Jin; Kim, Hongsik; Kim, Wun Jae; Ryu, Soo Bang; Ahn, Hanjong; Kim, Choung Soo.

In: Korean Journal of Urology, Vol. 47, No. 9, 01.09.2006, p. 963-967.

Research output: Contribution to journalArticle

Song, C, Park, JY, Lee, MS, Chung, H, Cho, YH, Kim, BW, Chang, SG, Kim, CI, Cheon, J, Lee, KS, Chung, SI, Chung, MK, Choi, HY, Lee, HM, Kim, SJ, Hong, SJ, Chung, JI, Yoon, SM, Lee, YG, Kim, HJ, Kim, H, Kim, WJ, Ryu, SB, Ahn, H & Kim, CS 2006, 'Korean nomogram for the prediction of recurrence-free survival after definitive surgery for renal cell carcinoma', Korean Journal of Urology, vol. 47, no. 9, pp. 963-967.
Song, Cheryn ; Park, Jong Yeon ; Lee, Moo Song ; Chung, Han ; Cho, Yong Hyun ; Kim, Bup Wan ; Chang, Sung Goo ; Kim, Chun Il ; Cheon, Jun ; Lee, Kyung Seop ; Chung, Se Il ; Chung, Moon Kee ; Choi, Han Yong ; Lee, Hyun Moo ; Kim, Se Joong ; Hong, Sung Joon ; Chung, Jae Il ; Yoon, Sang Min ; Lee, Yong Goo ; Kim, Hyung Jin ; Kim, Hongsik ; Kim, Wun Jae ; Ryu, Soo Bang ; Ahn, Hanjong ; Kim, Choung Soo. / Korean nomogram for the prediction of recurrence-free survival after definitive surgery for renal cell carcinoma. In: Korean Journal of Urology. 2006 ; Vol. 47, No. 9. pp. 963-967.
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abstract = "Purpose: This multiinstitutional study was to investigate the accuracy of the Kattan nomograms for the prediction of recurrence after definitive surgery for renal cell carcinoma (RCC) in Korean patients and develop a nomogram revised to complement the shortcomings. Materials and Methods: Clinical and pathological data of 1,866 patients with RCC who had been followed for at least 2 years after surgery in each participating institutes were reviewed as well as evidence of disease recurrence, defined to include local recurrence and distant metastasis. Accuracy of the Kattan nomograms' predictability in tumors 7cm or less was tested by calculating the area under the receiver-operating characteristics curve (AUC) and actuarial recurrence-free survival by Kaplan-Meier method. We used the Cox proportional hazard analysis to identify significant variables and develop prediction nomogram, and internally validated by bootstrapping method. Mean follow-up was 56.5 months (24-184). Results: Recurrence occurred in 12.5{\%} of the patients and correlated with the pathological stage, with 4.3{\%}, 7.9{\%}, 15.0{\%}, 22.6{\%}, 38.4{\%}, 58.3{\%} for stages T1a, T1b, T2, T3a, T3b/c and T4, respectively (p<0.001). The AUC of the Kattan nomograms was 0.276. Factors significantly predictive of recurrence were T stage (p<0.0001), presentation (p=0.006), preoperative hemoglobin (p=0.023) and gender (p=0.032). Actuarial 60-month recurrence-free survival was 87.9{\%} and using the prognostic factors, nomogram predicting 60-month recurrence-free survival was constructed. Conclusions: Korean nomogram complementing the preexisting nomograms for the prediction of recurrence-free survival after definitive surgery for RCC has been constructed, which may be useful in patient prognostication, counseling and follow-up planning.",
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author = "Cheryn Song and Park, {Jong Yeon} and Lee, {Moo Song} and Han Chung and Cho, {Yong Hyun} and Kim, {Bup Wan} and Chang, {Sung Goo} and Kim, {Chun Il} and Jun Cheon and Lee, {Kyung Seop} and Chung, {Se Il} and Chung, {Moon Kee} and Choi, {Han Yong} and Lee, {Hyun Moo} and Kim, {Se Joong} and Hong, {Sung Joon} and Chung, {Jae Il} and Yoon, {Sang Min} and Lee, {Yong Goo} and Kim, {Hyung Jin} and Hongsik Kim and Kim, {Wun Jae} and Ryu, {Soo Bang} and Hanjong Ahn and Kim, {Choung Soo}",
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T1 - Korean nomogram for the prediction of recurrence-free survival after definitive surgery for renal cell carcinoma

AU - Song, Cheryn

AU - Park, Jong Yeon

AU - Lee, Moo Song

AU - Chung, Han

AU - Cho, Yong Hyun

AU - Kim, Bup Wan

AU - Chang, Sung Goo

AU - Kim, Chun Il

AU - Cheon, Jun

AU - Lee, Kyung Seop

AU - Chung, Se Il

AU - Chung, Moon Kee

AU - Choi, Han Yong

AU - Lee, Hyun Moo

AU - Kim, Se Joong

AU - Hong, Sung Joon

AU - Chung, Jae Il

AU - Yoon, Sang Min

AU - Lee, Yong Goo

AU - Kim, Hyung Jin

AU - Kim, Hongsik

AU - Kim, Wun Jae

AU - Ryu, Soo Bang

AU - Ahn, Hanjong

AU - Kim, Choung Soo

PY - 2006/9/1

Y1 - 2006/9/1

N2 - Purpose: This multiinstitutional study was to investigate the accuracy of the Kattan nomograms for the prediction of recurrence after definitive surgery for renal cell carcinoma (RCC) in Korean patients and develop a nomogram revised to complement the shortcomings. Materials and Methods: Clinical and pathological data of 1,866 patients with RCC who had been followed for at least 2 years after surgery in each participating institutes were reviewed as well as evidence of disease recurrence, defined to include local recurrence and distant metastasis. Accuracy of the Kattan nomograms' predictability in tumors 7cm or less was tested by calculating the area under the receiver-operating characteristics curve (AUC) and actuarial recurrence-free survival by Kaplan-Meier method. We used the Cox proportional hazard analysis to identify significant variables and develop prediction nomogram, and internally validated by bootstrapping method. Mean follow-up was 56.5 months (24-184). Results: Recurrence occurred in 12.5% of the patients and correlated with the pathological stage, with 4.3%, 7.9%, 15.0%, 22.6%, 38.4%, 58.3% for stages T1a, T1b, T2, T3a, T3b/c and T4, respectively (p<0.001). The AUC of the Kattan nomograms was 0.276. Factors significantly predictive of recurrence were T stage (p<0.0001), presentation (p=0.006), preoperative hemoglobin (p=0.023) and gender (p=0.032). Actuarial 60-month recurrence-free survival was 87.9% and using the prognostic factors, nomogram predicting 60-month recurrence-free survival was constructed. Conclusions: Korean nomogram complementing the preexisting nomograms for the prediction of recurrence-free survival after definitive surgery for RCC has been constructed, which may be useful in patient prognostication, counseling and follow-up planning.

AB - Purpose: This multiinstitutional study was to investigate the accuracy of the Kattan nomograms for the prediction of recurrence after definitive surgery for renal cell carcinoma (RCC) in Korean patients and develop a nomogram revised to complement the shortcomings. Materials and Methods: Clinical and pathological data of 1,866 patients with RCC who had been followed for at least 2 years after surgery in each participating institutes were reviewed as well as evidence of disease recurrence, defined to include local recurrence and distant metastasis. Accuracy of the Kattan nomograms' predictability in tumors 7cm or less was tested by calculating the area under the receiver-operating characteristics curve (AUC) and actuarial recurrence-free survival by Kaplan-Meier method. We used the Cox proportional hazard analysis to identify significant variables and develop prediction nomogram, and internally validated by bootstrapping method. Mean follow-up was 56.5 months (24-184). Results: Recurrence occurred in 12.5% of the patients and correlated with the pathological stage, with 4.3%, 7.9%, 15.0%, 22.6%, 38.4%, 58.3% for stages T1a, T1b, T2, T3a, T3b/c and T4, respectively (p<0.001). The AUC of the Kattan nomograms was 0.276. Factors significantly predictive of recurrence were T stage (p<0.0001), presentation (p=0.006), preoperative hemoglobin (p=0.023) and gender (p=0.032). Actuarial 60-month recurrence-free survival was 87.9% and using the prognostic factors, nomogram predicting 60-month recurrence-free survival was constructed. Conclusions: Korean nomogram complementing the preexisting nomograms for the prediction of recurrence-free survival after definitive surgery for RCC has been constructed, which may be useful in patient prognostication, counseling and follow-up planning.

KW - Nomograms

KW - Renal neoplasm

KW - Survival, disease free

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