Korean patients with chronic lymphocytic leukemia show the similar types of chromosomal aberrations as those in Europe and North America

Yoon Hwan Chang, Junwan Park, Hee Chan Kim, Hong Ku Chun, Young Ree Kim, Myungshin Kim, Kyungja Han, Je Hwan Lee, Kyoo Hyung Lee, Han Ik Cho, Yun Song Lee, Dong Soon Lee

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8 Citations (Scopus)

Abstract

Chronic lymphocytic leukemia (CLL) is frequent in the West, but rare in Korea. In this study, the frequency of chromosome aberration in Korean CLL patients was examined by applying interphase fluorescence in situ hybridization (FISH). Conventional cytogenetic test and FISH were performed on bone marrow aspirates obtained from 16 CLL patients. By applying DNA probes (Vysis, Downers Grove, IL, USA), the deletion in 11q22-23, 13q14, 13q34, and 17p13, and trisomy 12 were examined. With FISH, molecular cytogenetic aberration was detected in 10 of 16 patients [63%, 95% confidence interval (CI) 39-86], whereas with conventional cytogenetic test, chromosomal aberration was detected only in 2 out of 13 cases (15%, 95% CI 0-35). In total, the cases with one or more chromosomal aberrations were 11 out of 16 cases (69%, 95% CI 46-92). The most frequently detected aberration was the 13q14 deletion (69%, 95% CI 44-94), followed by trisomy 12 (19%, 95% CI 0-38) and 11q22 deletion (14%, 95% CI 0-33). No deletion in 17p13 was observed. In conclusion, CLL in Korean is a heterogeneous genetic disorder, showing similar genetic changes in Europe and North America.

Original languageEnglish
Pages (from-to)695-699
Number of pages5
JournalLeukemia Research
Volume30
Issue number6
DOIs
Publication statusPublished - 2006 Jun
Externally publishedYes

Keywords

  • Chromosomal aberration
  • Chronic lymphocytic leukemia
  • Fluorescence in situ hybridization

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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    Chang, Y. H., Park, J., Kim, H. C., Chun, H. K., Kim, Y. R., Kim, M., Han, K., Lee, J. H., Lee, K. H., Cho, H. I., Lee, Y. S., & Lee, D. S. (2006). Korean patients with chronic lymphocytic leukemia show the similar types of chromosomal aberrations as those in Europe and North America. Leukemia Research, 30(6), 695-699. https://doi.org/10.1016/j.leukres.2005.10.013