TY - JOUR
T1 - Korean patients with chronic lymphocytic leukemia show the similar types of chromosomal aberrations as those in Europe and North America
AU - Chang, Yoon Hwan
AU - Park, Junwan
AU - Kim, Hee Chan
AU - Chun, Hong Ku
AU - Kim, Young Ree
AU - Kim, Myungshin
AU - Han, Kyungja
AU - Lee, Je Hwan
AU - Lee, Kyoo Hyung
AU - Cho, Han Ik
AU - Lee, Yun Song
AU - Lee, Dong Soon
N1 - Funding Information:
This study was supported by a grant from the National R&D Program for Cancer Control, Ministry of Health & Welfare, R. O. K. (02-1-0750) and National Research Laboratory Program of the Ministry of Science and Technology (M1-0302-00-0112).
PY - 2006/6
Y1 - 2006/6
N2 - Chronic lymphocytic leukemia (CLL) is frequent in the West, but rare in Korea. In this study, the frequency of chromosome aberration in Korean CLL patients was examined by applying interphase fluorescence in situ hybridization (FISH). Conventional cytogenetic test and FISH were performed on bone marrow aspirates obtained from 16 CLL patients. By applying DNA probes (Vysis, Downers Grove, IL, USA), the deletion in 11q22-23, 13q14, 13q34, and 17p13, and trisomy 12 were examined. With FISH, molecular cytogenetic aberration was detected in 10 of 16 patients [63%, 95% confidence interval (CI) 39-86], whereas with conventional cytogenetic test, chromosomal aberration was detected only in 2 out of 13 cases (15%, 95% CI 0-35). In total, the cases with one or more chromosomal aberrations were 11 out of 16 cases (69%, 95% CI 46-92). The most frequently detected aberration was the 13q14 deletion (69%, 95% CI 44-94), followed by trisomy 12 (19%, 95% CI 0-38) and 11q22 deletion (14%, 95% CI 0-33). No deletion in 17p13 was observed. In conclusion, CLL in Korean is a heterogeneous genetic disorder, showing similar genetic changes in Europe and North America.
AB - Chronic lymphocytic leukemia (CLL) is frequent in the West, but rare in Korea. In this study, the frequency of chromosome aberration in Korean CLL patients was examined by applying interphase fluorescence in situ hybridization (FISH). Conventional cytogenetic test and FISH were performed on bone marrow aspirates obtained from 16 CLL patients. By applying DNA probes (Vysis, Downers Grove, IL, USA), the deletion in 11q22-23, 13q14, 13q34, and 17p13, and trisomy 12 were examined. With FISH, molecular cytogenetic aberration was detected in 10 of 16 patients [63%, 95% confidence interval (CI) 39-86], whereas with conventional cytogenetic test, chromosomal aberration was detected only in 2 out of 13 cases (15%, 95% CI 0-35). In total, the cases with one or more chromosomal aberrations were 11 out of 16 cases (69%, 95% CI 46-92). The most frequently detected aberration was the 13q14 deletion (69%, 95% CI 44-94), followed by trisomy 12 (19%, 95% CI 0-38) and 11q22 deletion (14%, 95% CI 0-33). No deletion in 17p13 was observed. In conclusion, CLL in Korean is a heterogeneous genetic disorder, showing similar genetic changes in Europe and North America.
KW - Chromosomal aberration
KW - Chronic lymphocytic leukemia
KW - Fluorescence in situ hybridization
UR - http://www.scopus.com/inward/record.url?scp=33645296295&partnerID=8YFLogxK
U2 - 10.1016/j.leukres.2005.10.013
DO - 10.1016/j.leukres.2005.10.013
M3 - Article
C2 - 16297977
AN - SCOPUS:33645296295
VL - 30
SP - 695
EP - 699
JO - Leukemia Research
JF - Leukemia Research
SN - 0145-2126
IS - 6
ER -
