Korean red ginseng extract increases apoptosis by activation of the noxa pathway in colorectal cancer

Yoon A. Jeong, Bo Ram Kim, Dae Young Kim, Soyeon Jeong, Yoo Jin Na, Jung Lim Kim, Hye Kyeong Yun, Bu Gyeom Kim, Seong Hye Park, Min Jee Jo, Sun Il Lee, Byung Cheol Han, Dae Hee Lee, Sang Cheul Oh

Research output: Contribution to journalArticle

Abstract

Background: Although the anticancer activity of Korean Red Ginseng (KRG) has been known in various cancers, the mechanism of KRG-induced apoptosis is unknown in colorectal cancer (CRC). In our study, we examined whether KRG induces apoptosis in CRC cells. Methods: In the cell viability assay, the concentration of the appropriate KRG extracts was fixed at 2.5 mg/mL in numerous CRC cells. This fixed concentration was in other experiments, and it was confirmed that the KRG extracts induce apoptosis in CRC cells. Results: We found that KRG induced Noxa activation and apoptosis and increased endoplasmic reticulum stress via reactive oxygen species production. This indicated that KRG efficiently enhanced cell death in CRC cells. Conclusion: Our results show that KRG can be used as a possible anticancer drug for patients with CRC.

Original languageEnglish
Article number2026
JournalNutrients
Volume11
Issue number9
DOIs
Publication statusPublished - 2019 Sep 1

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Noxae
Panax
colorectal neoplasms
Colorectal Neoplasms
apoptosis
Apoptosis
extracts
Endoplasmic Reticulum Stress
antineoplastic agents
endoplasmic reticulum
cell viability
cell death
reactive oxygen species
Reactive Oxygen Species
Cell Survival
Cell Death
neoplasms
neoplasm cells

Keywords

  • Endoplasmic reticulum stress
  • Korean red ginseng
  • Noxa
  • Reactive oxygen species

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Korean red ginseng extract increases apoptosis by activation of the noxa pathway in colorectal cancer. / Jeong, Yoon A.; Kim, Bo Ram; Kim, Dae Young; Jeong, Soyeon; Na, Yoo Jin; Kim, Jung Lim; Yun, Hye Kyeong; Kim, Bu Gyeom; Park, Seong Hye; Jo, Min Jee; Lee, Sun Il; Han, Byung Cheol; Lee, Dae Hee; Oh, Sang Cheul.

In: Nutrients, Vol. 11, No. 9, 2026, 01.09.2019.

Research output: Contribution to journalArticle

Jeong, YA, Kim, BR, Kim, DY, Jeong, S, Na, YJ, Kim, JL, Yun, HK, Kim, BG, Park, SH, Jo, MJ, Lee, SI, Han, BC, Lee, DH & Oh, SC 2019, 'Korean red ginseng extract increases apoptosis by activation of the noxa pathway in colorectal cancer', Nutrients, vol. 11, no. 9, 2026. https://doi.org/10.3390/nu11092026
Jeong, Yoon A. ; Kim, Bo Ram ; Kim, Dae Young ; Jeong, Soyeon ; Na, Yoo Jin ; Kim, Jung Lim ; Yun, Hye Kyeong ; Kim, Bu Gyeom ; Park, Seong Hye ; Jo, Min Jee ; Lee, Sun Il ; Han, Byung Cheol ; Lee, Dae Hee ; Oh, Sang Cheul. / Korean red ginseng extract increases apoptosis by activation of the noxa pathway in colorectal cancer. In: Nutrients. 2019 ; Vol. 11, No. 9.
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AB - Background: Although the anticancer activity of Korean Red Ginseng (KRG) has been known in various cancers, the mechanism of KRG-induced apoptosis is unknown in colorectal cancer (CRC). In our study, we examined whether KRG induces apoptosis in CRC cells. Methods: In the cell viability assay, the concentration of the appropriate KRG extracts was fixed at 2.5 mg/mL in numerous CRC cells. This fixed concentration was in other experiments, and it was confirmed that the KRG extracts induce apoptosis in CRC cells. Results: We found that KRG induced Noxa activation and apoptosis and increased endoplasmic reticulum stress via reactive oxygen species production. This indicated that KRG efficiently enhanced cell death in CRC cells. Conclusion: Our results show that KRG can be used as a possible anticancer drug for patients with CRC.

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