La protein is required for efficient translation driven by encephalomyocarditis virus internal ribosomal entry site

Yoon Ki Kim, Sung Key Jang

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Translation of internal ribosomal entry site (IRES)-dependent mRNAs is mediated by RNA-binding proteins as well as canonical translation factors. In order to elucidate the roles of RNA-binding proteins in IRES-dependent translation, the role of polypyrimidine tract-binding protein (PTB) and La protein in encephalomyocarditis virus (EMCV) IRES-dependent translation was investigated. PTB was required for efficient EMCV IRES-driven translation but, intriguingly, an excess of PTB suppressed it. Such a translational suppression by surplus PTB was relieved by addition of La protein. A possible role for La protein in IRES-dependent translation is discussed.

Original languageEnglish
Pages (from-to)3159-3166
Number of pages8
JournalJournal of General Virology
Volume80
Issue number12
Publication statusPublished - 1999 Dec 10
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology
  • Virology

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