Lab-on-a-Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

Yangzhi Zhu, Shaopei Li, Jinghang Li, Natashya Falcone, Qingyu Cui, Shilp Shah, Martin C. Hartel, Ning Yu, Patric Young, Natan Roberto de Barros, Zhuohong Wu, Reihaneh Haghniaz, Menekse Ermis, Canran Wang, Heemin Kang, Junmin Lee, Solmaz Karamikamkar, Samad Ahadian, Vadim Jucaud, Mehmet R. DokmeciHan Jun Kim, Ali Khademhosseini

Research output: Contribution to journalReview articlepeer-review

Abstract

The eye is one of the most complex organs in the human body, containing rich and critical physiological information (e.g., intraocular pressure, corneal temperature, and pH) as well as a library of metabolite biomarkers (e.g., glucose, proteins, and specific ions). Smart contact lenses (SCLs) can serve as a wearable intelligent ocular prosthetic device capable of noninvasive and continuous monitoring of various essential physical/biochemical parameters and drug loading/delivery for the treatment of ocular diseases. Advances in SCL technologies and the growing public interest in personalized health are accelerating SCL research more than ever before. Here, the current status and potential of SCL development through a comprehensive review from fabrication to applications to commercialization are discussed. First, the material, fabrication, and platform designs of the SCLs for the diagnostic and therapeutic applications are discussed. Then, the latest advances in diagnostic and therapeutic SCLs for clinical translation are reviewed. Later, the established techniques for wearable power transfer and wireless data transmission applied to current SCL devices are summarized. An outlook, future opportunities, and challenges for developing next-generation SCL devices are also provided. With the rise in interest of SCL development, this comprehensive and essential review can serve as a new paradigm for the SCL devices.

Original languageEnglish
JournalAdvanced Materials
DOIs
Publication statusAccepted/In press - 2022

Keywords

  • bioelectronics
  • biosensors
  • contact lens
  • diagnostics
  • integrated systems
  • personalized healthcare
  • therapeutics
  • wearable electronics

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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