Abstract
Background and Objectives: We defined laboratory marker profiles typical of incomplete Kawasaki disease (iKD) during illness, especially with respect to the presence of a coronary artery abnormality such as coronary artery dilation or aneurysm. Methods: This retrospective study examined the clinical and laboratory markers of patients with iKD over time, along with those of patients with complete KD (cKD) and febrile controls. Results: Of 795 patients, 178 had iKD, 504 had cKD and 113 were febrile controls. During the transition from the acute to subacute phase, the age-adjusted hemoglobin levels and platelet counts were significantly lower and higher, respectively, in the subacute phase than in the acute phase in both iKD and cKD patients, which differed from those of febrile controls. Lower levels of acute and subacute age-adjusted hemoglobin levels in iKD patients (odds ratio [OR], 0.538 and 0.583; p=0.006 and 0.018, respectively) and higher subacute platelet counts in cKD patients (OR, 1.004; p=0.014) were correlated with the risk of coronary dilation. A higher acute neutrophil-to-lymphocyte ratio was associated with aneurysm only in cKD patients (OR, 1.059; p=0.044). Conclusions: The iKD patients share KD-specific laboratory marker profiles in terms of complete blood cell counts and acute phase reactant levels with cKD patients. However, the factors predicting coronary dilation differ according to the phenotype; lower acute and subacute age-adjusted hemoglobin levels predict coronary dilation only in iKD patients.
| Original language | English |
|---|---|
| Pages (from-to) | 287-295 |
| Number of pages | 9 |
| Journal | Korean Circulation Journal |
| Volume | 48 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2018 Apr 1 |
Fingerprint
Keywords
- Biomarkers
- Coronary artery disease
- Mucocutaneous lymph node syndrome
ASJC Scopus subject areas
- Internal Medicine
- Cardiology and Cardiovascular Medicine
Cite this
Laboratory markers in incomplete kawasaki disease according to coronary artery outcome. / Ha, Kee Soo; Jang, Giyoung; Lee, Jung Hwa; Lee, Kwang Chul; Son, Chang Sung.
In: Korean Circulation Journal, Vol. 48, No. 4, 01.04.2018, p. 287-295.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Laboratory markers in incomplete kawasaki disease according to coronary artery outcome
AU - Ha, Kee Soo
AU - Jang, Giyoung
AU - Lee, Jung Hwa
AU - Lee, Kwang Chul
AU - Son, Chang Sung
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Background and Objectives: We defined laboratory marker profiles typical of incomplete Kawasaki disease (iKD) during illness, especially with respect to the presence of a coronary artery abnormality such as coronary artery dilation or aneurysm. Methods: This retrospective study examined the clinical and laboratory markers of patients with iKD over time, along with those of patients with complete KD (cKD) and febrile controls. Results: Of 795 patients, 178 had iKD, 504 had cKD and 113 were febrile controls. During the transition from the acute to subacute phase, the age-adjusted hemoglobin levels and platelet counts were significantly lower and higher, respectively, in the subacute phase than in the acute phase in both iKD and cKD patients, which differed from those of febrile controls. Lower levels of acute and subacute age-adjusted hemoglobin levels in iKD patients (odds ratio [OR], 0.538 and 0.583; p=0.006 and 0.018, respectively) and higher subacute platelet counts in cKD patients (OR, 1.004; p=0.014) were correlated with the risk of coronary dilation. A higher acute neutrophil-to-lymphocyte ratio was associated with aneurysm only in cKD patients (OR, 1.059; p=0.044). Conclusions: The iKD patients share KD-specific laboratory marker profiles in terms of complete blood cell counts and acute phase reactant levels with cKD patients. However, the factors predicting coronary dilation differ according to the phenotype; lower acute and subacute age-adjusted hemoglobin levels predict coronary dilation only in iKD patients.
AB - Background and Objectives: We defined laboratory marker profiles typical of incomplete Kawasaki disease (iKD) during illness, especially with respect to the presence of a coronary artery abnormality such as coronary artery dilation or aneurysm. Methods: This retrospective study examined the clinical and laboratory markers of patients with iKD over time, along with those of patients with complete KD (cKD) and febrile controls. Results: Of 795 patients, 178 had iKD, 504 had cKD and 113 were febrile controls. During the transition from the acute to subacute phase, the age-adjusted hemoglobin levels and platelet counts were significantly lower and higher, respectively, in the subacute phase than in the acute phase in both iKD and cKD patients, which differed from those of febrile controls. Lower levels of acute and subacute age-adjusted hemoglobin levels in iKD patients (odds ratio [OR], 0.538 and 0.583; p=0.006 and 0.018, respectively) and higher subacute platelet counts in cKD patients (OR, 1.004; p=0.014) were correlated with the risk of coronary dilation. A higher acute neutrophil-to-lymphocyte ratio was associated with aneurysm only in cKD patients (OR, 1.059; p=0.044). Conclusions: The iKD patients share KD-specific laboratory marker profiles in terms of complete blood cell counts and acute phase reactant levels with cKD patients. However, the factors predicting coronary dilation differ according to the phenotype; lower acute and subacute age-adjusted hemoglobin levels predict coronary dilation only in iKD patients.
KW - Biomarkers
KW - Coronary artery disease
KW - Mucocutaneous lymph node syndrome
UR - http://www.scopus.com/inward/record.url?scp=85045066580&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85045066580&partnerID=8YFLogxK
U2 - 10.4070/kcj.2017.0342
DO - 10.4070/kcj.2017.0342
M3 - Review article
AN - SCOPUS:85045066580
VL - 48
SP - 287
EP - 295
JO - Korean Circulation Journal
JF - Korean Circulation Journal
SN - 1738-5520
IS - 4
ER -