Laboratory Surveillance of Influenza-Like Illness in Seven Teaching Hospitals, South Korea

2011-2012 Season

Ji Yun Noh, Joon-Young Song, Hee-Jin Cheong, Wonseok Choi, Jacob Lee, Jin Soo Lee, Seong Heon Wie, Hye Won Jeong, Young Keun Kim, Sung Hyuk Choi, Seung Baik Han, Byung Hak So, Hyun Kim, Woo Joo Kim

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background:A well-constructed and properly operating influenza surveillance scheme is essential for public health. This study was conducted to evaluate the distribution of respiratory viruses in patients with influenza-like illness (ILI) through the first teaching hospital-based surveillance scheme for ILI in South Korea.Methods:Respiratory specimens were obtained from adult patients (≥18 years) who visited the emergency department (ED) with ILI from week 40, 2011 to week 22, 2012. Multiplex PCR was performed to detect respiratory viruses: influenza virus, adenovirus, coronavirus, respiratory syncytial virus, rhinovirus, human metapneumovirus, parainfluenza virus, bocavirus, and enterovirus.Results:Among 1,983 patients who visited the ED with ILI, 811 (40.9%) were male. The median age of patients was 43 years. Influenza vaccination rate was 21.7% (430/1,983) during the 2011-2012 season. At least one comorbidity was found in 18% of patients. The positive rate of respiratory viruses was 52.1% (1,033/1,983) and the total number of detected viruses was 1,100. Influenza A virus was the dominant agent (677, 61.5%) in all age groups. The prevalence of human metapneumovirus was higher in patients more than 50 years old, while adenovirus was detected only in younger adults. In 58 (5.6%) cases, two or more respiratory viruses were detected. The co-incidence case was identified more frequently in patients with hematologic malignancy or organ transplantation recipients, however it was not related to clinical outcomes.Conclusion:This study is valuable as the first extensive laboratory surveillance of the epidemiology of respiratory viruses in ILI patients through a teaching hospital-based influenza surveillance system in South Korea.

Original languageEnglish
Article numbere64295
JournalPLoS One
Volume8
Issue number5
DOIs
Publication statusPublished - 2013 May 22

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Republic of Korea
South Korea
Viruses
Teaching Hospitals
influenza
Human Influenza
Teaching
monitoring
viruses
Human metapneumovirus
Metapneumovirus
Enterovirus
Adenoviridae
Orthomyxoviridae
Hospital Emergency Service
Bocavirus
organ transplantation
Paramyxoviridae Infections
Rhinovirus
Coronavirus

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Laboratory Surveillance of Influenza-Like Illness in Seven Teaching Hospitals, South Korea : 2011-2012 Season. / Noh, Ji Yun; Song, Joon-Young; Cheong, Hee-Jin; Choi, Wonseok; Lee, Jacob; Lee, Jin Soo; Wie, Seong Heon; Jeong, Hye Won; Kim, Young Keun; Choi, Sung Hyuk; Han, Seung Baik; So, Byung Hak; Kim, Hyun; Kim, Woo Joo.

In: PLoS One, Vol. 8, No. 5, e64295, 22.05.2013.

Research output: Contribution to journalArticle

Noh, Ji Yun ; Song, Joon-Young ; Cheong, Hee-Jin ; Choi, Wonseok ; Lee, Jacob ; Lee, Jin Soo ; Wie, Seong Heon ; Jeong, Hye Won ; Kim, Young Keun ; Choi, Sung Hyuk ; Han, Seung Baik ; So, Byung Hak ; Kim, Hyun ; Kim, Woo Joo. / Laboratory Surveillance of Influenza-Like Illness in Seven Teaching Hospitals, South Korea : 2011-2012 Season. In: PLoS One. 2013 ; Vol. 8, No. 5.
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title = "Laboratory Surveillance of Influenza-Like Illness in Seven Teaching Hospitals, South Korea: 2011-2012 Season",
abstract = "Background:A well-constructed and properly operating influenza surveillance scheme is essential for public health. This study was conducted to evaluate the distribution of respiratory viruses in patients with influenza-like illness (ILI) through the first teaching hospital-based surveillance scheme for ILI in South Korea.Methods:Respiratory specimens were obtained from adult patients (≥18 years) who visited the emergency department (ED) with ILI from week 40, 2011 to week 22, 2012. Multiplex PCR was performed to detect respiratory viruses: influenza virus, adenovirus, coronavirus, respiratory syncytial virus, rhinovirus, human metapneumovirus, parainfluenza virus, bocavirus, and enterovirus.Results:Among 1,983 patients who visited the ED with ILI, 811 (40.9{\%}) were male. The median age of patients was 43 years. Influenza vaccination rate was 21.7{\%} (430/1,983) during the 2011-2012 season. At least one comorbidity was found in 18{\%} of patients. The positive rate of respiratory viruses was 52.1{\%} (1,033/1,983) and the total number of detected viruses was 1,100. Influenza A virus was the dominant agent (677, 61.5{\%}) in all age groups. The prevalence of human metapneumovirus was higher in patients more than 50 years old, while adenovirus was detected only in younger adults. In 58 (5.6{\%}) cases, two or more respiratory viruses were detected. The co-incidence case was identified more frequently in patients with hematologic malignancy or organ transplantation recipients, however it was not related to clinical outcomes.Conclusion:This study is valuable as the first extensive laboratory surveillance of the epidemiology of respiratory viruses in ILI patients through a teaching hospital-based influenza surveillance system in South Korea.",
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AU - Noh, Ji Yun

AU - Song, Joon-Young

AU - Cheong, Hee-Jin

AU - Choi, Wonseok

AU - Lee, Jacob

AU - Lee, Jin Soo

AU - Wie, Seong Heon

AU - Jeong, Hye Won

AU - Kim, Young Keun

AU - Choi, Sung Hyuk

AU - Han, Seung Baik

AU - So, Byung Hak

AU - Kim, Hyun

AU - Kim, Woo Joo

PY - 2013/5/22

Y1 - 2013/5/22

N2 - Background:A well-constructed and properly operating influenza surveillance scheme is essential for public health. This study was conducted to evaluate the distribution of respiratory viruses in patients with influenza-like illness (ILI) through the first teaching hospital-based surveillance scheme for ILI in South Korea.Methods:Respiratory specimens were obtained from adult patients (≥18 years) who visited the emergency department (ED) with ILI from week 40, 2011 to week 22, 2012. Multiplex PCR was performed to detect respiratory viruses: influenza virus, adenovirus, coronavirus, respiratory syncytial virus, rhinovirus, human metapneumovirus, parainfluenza virus, bocavirus, and enterovirus.Results:Among 1,983 patients who visited the ED with ILI, 811 (40.9%) were male. The median age of patients was 43 years. Influenza vaccination rate was 21.7% (430/1,983) during the 2011-2012 season. At least one comorbidity was found in 18% of patients. The positive rate of respiratory viruses was 52.1% (1,033/1,983) and the total number of detected viruses was 1,100. Influenza A virus was the dominant agent (677, 61.5%) in all age groups. The prevalence of human metapneumovirus was higher in patients more than 50 years old, while adenovirus was detected only in younger adults. In 58 (5.6%) cases, two or more respiratory viruses were detected. The co-incidence case was identified more frequently in patients with hematologic malignancy or organ transplantation recipients, however it was not related to clinical outcomes.Conclusion:This study is valuable as the first extensive laboratory surveillance of the epidemiology of respiratory viruses in ILI patients through a teaching hospital-based influenza surveillance system in South Korea.

AB - Background:A well-constructed and properly operating influenza surveillance scheme is essential for public health. This study was conducted to evaluate the distribution of respiratory viruses in patients with influenza-like illness (ILI) through the first teaching hospital-based surveillance scheme for ILI in South Korea.Methods:Respiratory specimens were obtained from adult patients (≥18 years) who visited the emergency department (ED) with ILI from week 40, 2011 to week 22, 2012. Multiplex PCR was performed to detect respiratory viruses: influenza virus, adenovirus, coronavirus, respiratory syncytial virus, rhinovirus, human metapneumovirus, parainfluenza virus, bocavirus, and enterovirus.Results:Among 1,983 patients who visited the ED with ILI, 811 (40.9%) were male. The median age of patients was 43 years. Influenza vaccination rate was 21.7% (430/1,983) during the 2011-2012 season. At least one comorbidity was found in 18% of patients. The positive rate of respiratory viruses was 52.1% (1,033/1,983) and the total number of detected viruses was 1,100. Influenza A virus was the dominant agent (677, 61.5%) in all age groups. The prevalence of human metapneumovirus was higher in patients more than 50 years old, while adenovirus was detected only in younger adults. In 58 (5.6%) cases, two or more respiratory viruses were detected. The co-incidence case was identified more frequently in patients with hematologic malignancy or organ transplantation recipients, however it was not related to clinical outcomes.Conclusion:This study is valuable as the first extensive laboratory surveillance of the epidemiology of respiratory viruses in ILI patients through a teaching hospital-based influenza surveillance system in South Korea.

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