Lack of association between ACE and bradykinin B2 receptor gene polymorphisms and ACE inhibitor-induced coughing in hypertensive Koreans

S. W. Woo, S. Bang, M. W. Chung, S. K. Jin, Y. S. Kim, Sung Ho Lee

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective: Angiotensin converting enzyme (ACE) inhibitors are used widely in therapy for hypertension, congestive heart failure and myocardial infarction. However, coughing, one of their major adverse effects limits their use. It is documented that Asians are more liable to coughing than Europeans. The aim of this study was to investigate genetic polymorphism involved in ACE inhibitor-induced coughing. Methods: We monitored hypertensive subjects (n = 110) treated with ACE inhibitors, and tested for any associations between ACE inhibitor-induced coughing and polymorphisms in the genes for ACE and the bradykinin B2 receptor, which are suspected to be related to coughing. Results & Discussion: We found no significant differences between the groups with coughing and without coughing in the frequency of ACE I/D (Insertion/Deletion) polymorphisms. One single nucleotide polymorphism was discovered in the promoter (-58T/C) and, one in intron-exon junction upsteam of exon 2 (-59C/A), of the bradykinin B2 receptor gene. However, no significant correlation was found between those genotypes or allele distributions and ACE inhibitor-induced coughing. Conclusion: We found no significant links between polymorphisms of the ACE gene or bradykinin B2 receptor gene with ACE inhibitor-induced coughing in hypertensive Koreans. But, the topic remains controversial and requires more study.

Original languageEnglish
Pages (from-to)561-567
Number of pages7
JournalJournal of Clinical Pharmacy and Therapeutics
Volume34
Issue number5
DOIs
Publication statusPublished - 2009 Oct 1

Fingerprint

Bradykinin B2 Receptors
Peptidyl-Dipeptidase A
Angiotensin-Converting Enzyme Inhibitors
Genes
Exons
Genetic Polymorphisms
Introns
Single Nucleotide Polymorphism
Heart Failure
Alleles
Myocardial Infarction
Genotype
Hypertension

Keywords

  • ACE gene
  • Angiotensin converting enzyme inhibitors
  • Bradykinin B2 receptor gene
  • Coughing
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Lack of association between ACE and bradykinin B2 receptor gene polymorphisms and ACE inhibitor-induced coughing in hypertensive Koreans. / Woo, S. W.; Bang, S.; Chung, M. W.; Jin, S. K.; Kim, Y. S.; Lee, Sung Ho.

In: Journal of Clinical Pharmacy and Therapeutics, Vol. 34, No. 5, 01.10.2009, p. 561-567.

Research output: Contribution to journalArticle

@article{273f5690ed8b4fbaa98ae34f098116d7,
title = "Lack of association between ACE and bradykinin B2 receptor gene polymorphisms and ACE inhibitor-induced coughing in hypertensive Koreans",
abstract = "Objective: Angiotensin converting enzyme (ACE) inhibitors are used widely in therapy for hypertension, congestive heart failure and myocardial infarction. However, coughing, one of their major adverse effects limits their use. It is documented that Asians are more liable to coughing than Europeans. The aim of this study was to investigate genetic polymorphism involved in ACE inhibitor-induced coughing. Methods: We monitored hypertensive subjects (n = 110) treated with ACE inhibitors, and tested for any associations between ACE inhibitor-induced coughing and polymorphisms in the genes for ACE and the bradykinin B2 receptor, which are suspected to be related to coughing. Results & Discussion: We found no significant differences between the groups with coughing and without coughing in the frequency of ACE I/D (Insertion/Deletion) polymorphisms. One single nucleotide polymorphism was discovered in the promoter (-58T/C) and, one in intron-exon junction upsteam of exon 2 (-59C/A), of the bradykinin B2 receptor gene. However, no significant correlation was found between those genotypes or allele distributions and ACE inhibitor-induced coughing. Conclusion: We found no significant links between polymorphisms of the ACE gene or bradykinin B2 receptor gene with ACE inhibitor-induced coughing in hypertensive Koreans. But, the topic remains controversial and requires more study.",
keywords = "ACE gene, Angiotensin converting enzyme inhibitors, Bradykinin B2 receptor gene, Coughing, Single nucleotide polymorphism",
author = "Woo, {S. W.} and S. Bang and Chung, {M. W.} and Jin, {S. K.} and Kim, {Y. S.} and Lee, {Sung Ho}",
year = "2009",
month = "10",
day = "1",
doi = "10.1111/j.1365-2710.2009.01028.x",
language = "English",
volume = "34",
pages = "561--567",
journal = "Journal of Clinical Pharmacy and Therapeutics",
issn = "0269-4727",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Lack of association between ACE and bradykinin B2 receptor gene polymorphisms and ACE inhibitor-induced coughing in hypertensive Koreans

AU - Woo, S. W.

AU - Bang, S.

AU - Chung, M. W.

AU - Jin, S. K.

AU - Kim, Y. S.

AU - Lee, Sung Ho

PY - 2009/10/1

Y1 - 2009/10/1

N2 - Objective: Angiotensin converting enzyme (ACE) inhibitors are used widely in therapy for hypertension, congestive heart failure and myocardial infarction. However, coughing, one of their major adverse effects limits their use. It is documented that Asians are more liable to coughing than Europeans. The aim of this study was to investigate genetic polymorphism involved in ACE inhibitor-induced coughing. Methods: We monitored hypertensive subjects (n = 110) treated with ACE inhibitors, and tested for any associations between ACE inhibitor-induced coughing and polymorphisms in the genes for ACE and the bradykinin B2 receptor, which are suspected to be related to coughing. Results & Discussion: We found no significant differences between the groups with coughing and without coughing in the frequency of ACE I/D (Insertion/Deletion) polymorphisms. One single nucleotide polymorphism was discovered in the promoter (-58T/C) and, one in intron-exon junction upsteam of exon 2 (-59C/A), of the bradykinin B2 receptor gene. However, no significant correlation was found between those genotypes or allele distributions and ACE inhibitor-induced coughing. Conclusion: We found no significant links between polymorphisms of the ACE gene or bradykinin B2 receptor gene with ACE inhibitor-induced coughing in hypertensive Koreans. But, the topic remains controversial and requires more study.

AB - Objective: Angiotensin converting enzyme (ACE) inhibitors are used widely in therapy for hypertension, congestive heart failure and myocardial infarction. However, coughing, one of their major adverse effects limits their use. It is documented that Asians are more liable to coughing than Europeans. The aim of this study was to investigate genetic polymorphism involved in ACE inhibitor-induced coughing. Methods: We monitored hypertensive subjects (n = 110) treated with ACE inhibitors, and tested for any associations between ACE inhibitor-induced coughing and polymorphisms in the genes for ACE and the bradykinin B2 receptor, which are suspected to be related to coughing. Results & Discussion: We found no significant differences between the groups with coughing and without coughing in the frequency of ACE I/D (Insertion/Deletion) polymorphisms. One single nucleotide polymorphism was discovered in the promoter (-58T/C) and, one in intron-exon junction upsteam of exon 2 (-59C/A), of the bradykinin B2 receptor gene. However, no significant correlation was found between those genotypes or allele distributions and ACE inhibitor-induced coughing. Conclusion: We found no significant links between polymorphisms of the ACE gene or bradykinin B2 receptor gene with ACE inhibitor-induced coughing in hypertensive Koreans. But, the topic remains controversial and requires more study.

KW - ACE gene

KW - Angiotensin converting enzyme inhibitors

KW - Bradykinin B2 receptor gene

KW - Coughing

KW - Single nucleotide polymorphism

UR - http://www.scopus.com/inward/record.url?scp=70049083398&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70049083398&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2710.2009.01028.x

DO - 10.1111/j.1365-2710.2009.01028.x

M3 - Article

C2 - 19744011

AN - SCOPUS:70049083398

VL - 34

SP - 561

EP - 567

JO - Journal of Clinical Pharmacy and Therapeutics

JF - Journal of Clinical Pharmacy and Therapeutics

SN - 0269-4727

IS - 5

ER -