Lack of association of fragile histidine triad (FHIT) polymorphisms with lung cancer in the Korean population

Hae Yun Jung; Jae Sook Sung; Young Mi Whang; Hyoung Doo Shin; Byung Lae Park; Jun Suk Kim; Sang Won Shin; Hee Yun Seo; Hwa Jung Sung; In Keun Choi; Sang Cheul Oh; Jae Hong Seo; Yeul Hong Kim

doi:10.1007/s10038-007-0169-7

Lack of association of fragile histidine triad (FHIT) polymorphisms with lung cancer in the Korean population

Hae Yun Jung, Jae Sook Sung, Young Mi Whang, Hyoung Doo Shin, Byung Lae Park, Jun Suk Kim, Sang Won Shin, Hee Yun Seo, Hwa Jung Sung, In Keun Choi, Sang Cheul Oh, Jae Hong Seo, Yeul Hong Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The fragile histidine triad (FHIT), which was located on chromosome 3p14.2, was currently considered a promising candidate for a tumor suppressor gene. FHIT performed a crucial function in the tumorigenesis of lung cancer. The inactivation of FHIT via genetic alterations, including the chromosomal deletions and aberrant transcription, are often associated with lung cancer. In this study, the association between FHIT and lung cancer development was evaluated in a study of Korean patients. A total of 299 Korean lung cancer patients and 296 control subjects were recruited into this study. Direct DNA sequencing and TaqMan analysis were employed. Logistic regression analyses were conducted in order to characterize the association between FHIT polymorphisms and lung cancer risk. Via direct sequencing in 24 Korean individuals, 27 sequence variants were identified. Eleven of these polymorphisms were selected for a larger scale genotyping (n = 595). Our finding indicated that the polymorphisms and haplotypes in the FHIT gene are not associated with lung cancer in the Korean population.

Original language	English
Pages (from-to)	668-674
Number of pages	7
Journal	Journal of Human Genetics
Volume	52
Issue number	8
DOIs	https://doi.org/10.1007/s10038-007-0169-7
Publication status	Published - 2007 Aug

Keywords

Fragile histidine triad (FHIT)
Haplotypes
Korean population
Lung cancer
Single nucleotide polymorphisms

ASJC Scopus subject areas

Genetics
Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10038-007-0169-7

Cite this

@article{c36b08a6f6f74b2aab74e06f484dd3ea,

title = "Lack of association of fragile histidine triad (FHIT) polymorphisms with lung cancer in the Korean population",

abstract = "The fragile histidine triad (FHIT), which was located on chromosome 3p14.2, was currently considered a promising candidate for a tumor suppressor gene. FHIT performed a crucial function in the tumorigenesis of lung cancer. The inactivation of FHIT via genetic alterations, including the chromosomal deletions and aberrant transcription, are often associated with lung cancer. In this study, the association between FHIT and lung cancer development was evaluated in a study of Korean patients. A total of 299 Korean lung cancer patients and 296 control subjects were recruited into this study. Direct DNA sequencing and TaqMan analysis were employed. Logistic regression analyses were conducted in order to characterize the association between FHIT polymorphisms and lung cancer risk. Via direct sequencing in 24 Korean individuals, 27 sequence variants were identified. Eleven of these polymorphisms were selected for a larger scale genotyping (n = 595). Our finding indicated that the polymorphisms and haplotypes in the FHIT gene are not associated with lung cancer in the Korean population.",

keywords = "Fragile histidine triad (FHIT), Haplotypes, Korean population, Lung cancer, Single nucleotide polymorphisms",

author = "Jung, {Hae Yun} and Sung, {Jae Sook} and Whang, {Young Mi} and Shin, {Hyoung Doo} and Park, {Byung Lae} and Kim, {Jun Suk} and Shin, {Sang Won} and Seo, {Hee Yun} and Sung, {Hwa Jung} and Choi, {In Keun} and Oh, {Sang Cheul} and Seo, {Jae Hong} and Kim, {Yeul Hong}",

year = "2007",

month = aug,

doi = "10.1007/s10038-007-0169-7",

language = "English",

volume = "52",

pages = "668--674",

journal = "Journal of Human Genetics",

issn = "1434-5161",

publisher = "Nature Publishing Group",

number = "8",

}

TY - JOUR

T1 - Lack of association of fragile histidine triad (FHIT) polymorphisms with lung cancer in the Korean population

AU - Jung, Hae Yun

AU - Sung, Jae Sook

AU - Whang, Young Mi

AU - Shin, Hyoung Doo

AU - Park, Byung Lae

AU - Kim, Jun Suk

AU - Shin, Sang Won

AU - Seo, Hee Yun

AU - Sung, Hwa Jung

AU - Choi, In Keun

AU - Oh, Sang Cheul

AU - Seo, Jae Hong

AU - Kim, Yeul Hong

PY - 2007/8

Y1 - 2007/8

N2 - The fragile histidine triad (FHIT), which was located on chromosome 3p14.2, was currently considered a promising candidate for a tumor suppressor gene. FHIT performed a crucial function in the tumorigenesis of lung cancer. The inactivation of FHIT via genetic alterations, including the chromosomal deletions and aberrant transcription, are often associated with lung cancer. In this study, the association between FHIT and lung cancer development was evaluated in a study of Korean patients. A total of 299 Korean lung cancer patients and 296 control subjects were recruited into this study. Direct DNA sequencing and TaqMan analysis were employed. Logistic regression analyses were conducted in order to characterize the association between FHIT polymorphisms and lung cancer risk. Via direct sequencing in 24 Korean individuals, 27 sequence variants were identified. Eleven of these polymorphisms were selected for a larger scale genotyping (n = 595). Our finding indicated that the polymorphisms and haplotypes in the FHIT gene are not associated with lung cancer in the Korean population.

AB - The fragile histidine triad (FHIT), which was located on chromosome 3p14.2, was currently considered a promising candidate for a tumor suppressor gene. FHIT performed a crucial function in the tumorigenesis of lung cancer. The inactivation of FHIT via genetic alterations, including the chromosomal deletions and aberrant transcription, are often associated with lung cancer. In this study, the association between FHIT and lung cancer development was evaluated in a study of Korean patients. A total of 299 Korean lung cancer patients and 296 control subjects were recruited into this study. Direct DNA sequencing and TaqMan analysis were employed. Logistic regression analyses were conducted in order to characterize the association between FHIT polymorphisms and lung cancer risk. Via direct sequencing in 24 Korean individuals, 27 sequence variants were identified. Eleven of these polymorphisms were selected for a larger scale genotyping (n = 595). Our finding indicated that the polymorphisms and haplotypes in the FHIT gene are not associated with lung cancer in the Korean population.

KW - Fragile histidine triad (FHIT)

KW - Haplotypes

KW - Korean population

KW - Lung cancer

KW - Single nucleotide polymorphisms

UR - http://www.scopus.com/inward/record.url?scp=34547138395&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547138395&partnerID=8YFLogxK

U2 - 10.1007/s10038-007-0169-7

DO - 10.1007/s10038-007-0169-7

M3 - Article

C2 - 17609851

AN - SCOPUS:34547138395

SN - 1434-5161

VL - 52

SP - 668

EP - 674

JO - Journal of Human Genetics

JF - Journal of Human Genetics

IS - 8

ER -

Lack of association of fragile histidine triad (FHIT) polymorphisms with lung cancer in the Korean population

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this