Lack of association of fragile histidine triad (FHIT) polymorphisms with lung cancer in the Korean population

Hae Yun Jung, Jae Sook Sung, Young Mi Whang, Hyoung Doo Shin, Byung Lae Park, Jun Suk Kim, Sang Won Shin, Hee Yun Seo, Hwa Jung Sung, In Keun Choi, Sang Cheul Oh, Jae Hong Seo, Yeul Hong Kim

Research output: Contribution to journalArticle

Abstract

The fragile histidine triad (FHIT), which was located on chromosome 3p14.2, was currently considered a promising candidate for a tumor suppressor gene. FHIT performed a crucial function in the tumorigenesis of lung cancer. The inactivation of FHIT via genetic alterations, including the chromosomal deletions and aberrant transcription, are often associated with lung cancer. In this study, the association between FHIT and lung cancer development was evaluated in a study of Korean patients. A total of 299 Korean lung cancer patients and 296 control subjects were recruited into this study. Direct DNA sequencing and TaqMan analysis were employed. Logistic regression analyses were conducted in order to characterize the association between FHIT polymorphisms and lung cancer risk. Via direct sequencing in 24 Korean individuals, 27 sequence variants were identified. Eleven of these polymorphisms were selected for a larger scale genotyping (n = 595). Our finding indicated that the polymorphisms and haplotypes in the FHIT gene are not associated with lung cancer in the Korean population.

Original languageEnglish
Pages (from-to)668-674
Number of pages7
JournalJournal of Human Genetics
Volume52
Issue number8
DOIs
Publication statusPublished - 2007 Aug

Keywords

  • Fragile histidine triad (FHIT)
  • Haplotypes
  • Korean population
  • Lung cancer
  • Single nucleotide polymorphisms

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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  • Cite this

    Jung, H. Y., Sung, J. S., Whang, Y. M., Shin, H. D., Park, B. L., Kim, J. S., Shin, S. W., Seo, H. Y., Sung, H. J., Choi, I. K., Oh, S. C., Seo, J. H., & Kim, Y. H. (2007). Lack of association of fragile histidine triad (FHIT) polymorphisms with lung cancer in the Korean population. Journal of Human Genetics, 52(8), 668-674. https://doi.org/10.1007/s10038-007-0169-7