Lack of association of TNF-alpha promoter polymorphisms with ankylosing spondylitis

a meta-analysis.

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

OBJECTIVES: Genetic factors, in addition to the HLA-B27, could play a role in the pathogenesis of AS. TNF-alpha promoter polymorphisms have been reported to be associated with AS susceptibility, but the results of these previous studies have been inconsistent. The aim of this study was to explore whether TNF-alpha promoter polymorphisms confer susceptibility to AS. METHODS: We conducted a random effect meta-analysis on the association of the A/A genotype (the recessive effect), the A/A + A/G genotype (the dominant effect) and the A allele of the TNF-alpha -308 and -238 polymorphisms with AS. RESULTS: Eight studies, consisting of seven European studies and one Latin American study, were included in this meta-analysis. Any association between AS and the TNF-alpha -308 A allele was not found [odds ratio (OR) = 0.911; 95% CI 0.512, 1.286; P = 0.636; I(2) = 73.8]. There was also no association of the TNF-alpha -308 AA and AA+AG genotypes with AS. Meta-analysis of the TNF-alpha -238 polymorphisms showed no association with AS (OR for A allele = 0.930; 95% CI 0.498, 1.737; P = 0.821; I(2) = 71.6). Subgroup analysis by ethnicity and HLA-B27 positivity did not change the results for the association of the TNF-alpha -308 and -238 polymorphisms with AS. CONCLUSIONS: This meta-analysis including 2247 subjects has shown that there is a lack of association of the TNF-alpha -308 A/G and -238 A/G polymorphisms with AS.

Original languageEnglish
Pages (from-to)1359-1362
Number of pages4
JournalRheumatology (Oxford, England)
Volume48
Issue number11
Publication statusPublished - 2009 Nov 1

Fingerprint

Ankylosing Spondylitis
Meta-Analysis
Tumor Necrosis Factor-alpha
HLA-B27 Antigen
Alleles
Genotype
Odds Ratio

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

Cite this

Lack of association of TNF-alpha promoter polymorphisms with ankylosing spondylitis : a meta-analysis. / Lee, Young Ho; Song, Gwan Gyu.

In: Rheumatology (Oxford, England), Vol. 48, No. 11, 01.11.2009, p. 1359-1362.

Research output: Contribution to journalReview article

@article{146fdf949c454924998c80b5f6262647,
title = "Lack of association of TNF-alpha promoter polymorphisms with ankylosing spondylitis: a meta-analysis.",
abstract = "OBJECTIVES: Genetic factors, in addition to the HLA-B27, could play a role in the pathogenesis of AS. TNF-alpha promoter polymorphisms have been reported to be associated with AS susceptibility, but the results of these previous studies have been inconsistent. The aim of this study was to explore whether TNF-alpha promoter polymorphisms confer susceptibility to AS. METHODS: We conducted a random effect meta-analysis on the association of the A/A genotype (the recessive effect), the A/A + A/G genotype (the dominant effect) and the A allele of the TNF-alpha -308 and -238 polymorphisms with AS. RESULTS: Eight studies, consisting of seven European studies and one Latin American study, were included in this meta-analysis. Any association between AS and the TNF-alpha -308 A allele was not found [odds ratio (OR) = 0.911; 95{\%} CI 0.512, 1.286; P = 0.636; I(2) = 73.8]. There was also no association of the TNF-alpha -308 AA and AA+AG genotypes with AS. Meta-analysis of the TNF-alpha -238 polymorphisms showed no association with AS (OR for A allele = 0.930; 95{\%} CI 0.498, 1.737; P = 0.821; I(2) = 71.6). Subgroup analysis by ethnicity and HLA-B27 positivity did not change the results for the association of the TNF-alpha -308 and -238 polymorphisms with AS. CONCLUSIONS: This meta-analysis including 2247 subjects has shown that there is a lack of association of the TNF-alpha -308 A/G and -238 A/G polymorphisms with AS.",
author = "Lee, {Young Ho} and Song, {Gwan Gyu}",
year = "2009",
month = "11",
day = "1",
language = "English",
volume = "48",
pages = "1359--1362",
journal = "Rheumatology",
issn = "1462-0324",
publisher = "Oxford University Press",
number = "11",

}

TY - JOUR

T1 - Lack of association of TNF-alpha promoter polymorphisms with ankylosing spondylitis

T2 - a meta-analysis.

AU - Lee, Young Ho

AU - Song, Gwan Gyu

PY - 2009/11/1

Y1 - 2009/11/1

N2 - OBJECTIVES: Genetic factors, in addition to the HLA-B27, could play a role in the pathogenesis of AS. TNF-alpha promoter polymorphisms have been reported to be associated with AS susceptibility, but the results of these previous studies have been inconsistent. The aim of this study was to explore whether TNF-alpha promoter polymorphisms confer susceptibility to AS. METHODS: We conducted a random effect meta-analysis on the association of the A/A genotype (the recessive effect), the A/A + A/G genotype (the dominant effect) and the A allele of the TNF-alpha -308 and -238 polymorphisms with AS. RESULTS: Eight studies, consisting of seven European studies and one Latin American study, were included in this meta-analysis. Any association between AS and the TNF-alpha -308 A allele was not found [odds ratio (OR) = 0.911; 95% CI 0.512, 1.286; P = 0.636; I(2) = 73.8]. There was also no association of the TNF-alpha -308 AA and AA+AG genotypes with AS. Meta-analysis of the TNF-alpha -238 polymorphisms showed no association with AS (OR for A allele = 0.930; 95% CI 0.498, 1.737; P = 0.821; I(2) = 71.6). Subgroup analysis by ethnicity and HLA-B27 positivity did not change the results for the association of the TNF-alpha -308 and -238 polymorphisms with AS. CONCLUSIONS: This meta-analysis including 2247 subjects has shown that there is a lack of association of the TNF-alpha -308 A/G and -238 A/G polymorphisms with AS.

AB - OBJECTIVES: Genetic factors, in addition to the HLA-B27, could play a role in the pathogenesis of AS. TNF-alpha promoter polymorphisms have been reported to be associated with AS susceptibility, but the results of these previous studies have been inconsistent. The aim of this study was to explore whether TNF-alpha promoter polymorphisms confer susceptibility to AS. METHODS: We conducted a random effect meta-analysis on the association of the A/A genotype (the recessive effect), the A/A + A/G genotype (the dominant effect) and the A allele of the TNF-alpha -308 and -238 polymorphisms with AS. RESULTS: Eight studies, consisting of seven European studies and one Latin American study, were included in this meta-analysis. Any association between AS and the TNF-alpha -308 A allele was not found [odds ratio (OR) = 0.911; 95% CI 0.512, 1.286; P = 0.636; I(2) = 73.8]. There was also no association of the TNF-alpha -308 AA and AA+AG genotypes with AS. Meta-analysis of the TNF-alpha -238 polymorphisms showed no association with AS (OR for A allele = 0.930; 95% CI 0.498, 1.737; P = 0.821; I(2) = 71.6). Subgroup analysis by ethnicity and HLA-B27 positivity did not change the results for the association of the TNF-alpha -308 and -238 polymorphisms with AS. CONCLUSIONS: This meta-analysis including 2247 subjects has shown that there is a lack of association of the TNF-alpha -308 A/G and -238 A/G polymorphisms with AS.

UR - http://www.scopus.com/inward/record.url?scp=73349132069&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73349132069&partnerID=8YFLogxK

M3 - Review article

VL - 48

SP - 1359

EP - 1362

JO - Rheumatology

JF - Rheumatology

SN - 1462-0324

IS - 11

ER -