Lack of Bcl10 mutations in malignant cartilaginous tumors.

Yong Koo Park, Hye Rim Park, Youn Wha Kim, Sung-Gil Chi, K. Krishnan Unni

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The Bcl10 gene was recently isolated from the breakpoint region of t(1;14)(p22;q32) in mucosa-associated lymphoid tissue (MALT) lymphomas. Somatic mutations of Bcl10 were found in not only t(1;14)-bearing MALT lymphomas, but also a wide range of other tumors. To clarify the actual frequency and spectrum of Bcl10 mutations in primary malignant chondrogenic tumors, we examined 89 cases of malignant chondrogenic tumors comprising 17 conventional chondrosarcomas, 33 mesenchymal chondrosarcomas, and 39 clear cell chondrosarcomas. Polymerase chain reaction single-stranded conformation polymorphism and sequencing analyses were done. No Bcl10 mutations were found in our series of malignant chondrogenic tumors. While screening for mutations, we also found three polymorphisms at codons 8 exon 1 of the Bcl10 gene. Our results strongly suggest that somatic mutations of Bcl10 are extremely rare in malignant cartilaginous tumors and do not commonly contribute to their molecular pathogenesis.

Original languageEnglish
Pages (from-to)217-219
Number of pages3
JournalInternational Journal of Molecular Medicine
Volume9
Issue number3
Publication statusPublished - 2002 Mar 1
Externally publishedYes

Fingerprint

Mutation
Marginal Zone B-Cell Lymphoma
Chondrosarcoma
Neoplasms
Mesenchymal Chondrosarcoma
Codon
Genes
Exons
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Genetics

Cite this

Park, Y. K., Park, H. R., Kim, Y. W., Chi, S-G., & Unni, K. K. (2002). Lack of Bcl10 mutations in malignant cartilaginous tumors. International Journal of Molecular Medicine, 9(3), 217-219.

Lack of Bcl10 mutations in malignant cartilaginous tumors. / Park, Yong Koo; Park, Hye Rim; Kim, Youn Wha; Chi, Sung-Gil; Unni, K. Krishnan.

In: International Journal of Molecular Medicine, Vol. 9, No. 3, 01.03.2002, p. 217-219.

Research output: Contribution to journalArticle

Park, YK, Park, HR, Kim, YW, Chi, S-G & Unni, KK 2002, 'Lack of Bcl10 mutations in malignant cartilaginous tumors.', International Journal of Molecular Medicine, vol. 9, no. 3, pp. 217-219.
Park, Yong Koo ; Park, Hye Rim ; Kim, Youn Wha ; Chi, Sung-Gil ; Unni, K. Krishnan. / Lack of Bcl10 mutations in malignant cartilaginous tumors. In: International Journal of Molecular Medicine. 2002 ; Vol. 9, No. 3. pp. 217-219.
@article{8ff8bde59f7343c2809a5a7600aecead,
title = "Lack of Bcl10 mutations in malignant cartilaginous tumors.",
abstract = "The Bcl10 gene was recently isolated from the breakpoint region of t(1;14)(p22;q32) in mucosa-associated lymphoid tissue (MALT) lymphomas. Somatic mutations of Bcl10 were found in not only t(1;14)-bearing MALT lymphomas, but also a wide range of other tumors. To clarify the actual frequency and spectrum of Bcl10 mutations in primary malignant chondrogenic tumors, we examined 89 cases of malignant chondrogenic tumors comprising 17 conventional chondrosarcomas, 33 mesenchymal chondrosarcomas, and 39 clear cell chondrosarcomas. Polymerase chain reaction single-stranded conformation polymorphism and sequencing analyses were done. No Bcl10 mutations were found in our series of malignant chondrogenic tumors. While screening for mutations, we also found three polymorphisms at codons 8 exon 1 of the Bcl10 gene. Our results strongly suggest that somatic mutations of Bcl10 are extremely rare in malignant cartilaginous tumors and do not commonly contribute to their molecular pathogenesis.",
author = "Park, {Yong Koo} and Park, {Hye Rim} and Kim, {Youn Wha} and Sung-Gil Chi and Unni, {K. Krishnan}",
year = "2002",
month = "3",
day = "1",
language = "English",
volume = "9",
pages = "217--219",
journal = "International Journal of Molecular Medicine",
issn = "1107-3756",
publisher = "Spandidos Publications",
number = "3",

}

TY - JOUR

T1 - Lack of Bcl10 mutations in malignant cartilaginous tumors.

AU - Park, Yong Koo

AU - Park, Hye Rim

AU - Kim, Youn Wha

AU - Chi, Sung-Gil

AU - Unni, K. Krishnan

PY - 2002/3/1

Y1 - 2002/3/1

N2 - The Bcl10 gene was recently isolated from the breakpoint region of t(1;14)(p22;q32) in mucosa-associated lymphoid tissue (MALT) lymphomas. Somatic mutations of Bcl10 were found in not only t(1;14)-bearing MALT lymphomas, but also a wide range of other tumors. To clarify the actual frequency and spectrum of Bcl10 mutations in primary malignant chondrogenic tumors, we examined 89 cases of malignant chondrogenic tumors comprising 17 conventional chondrosarcomas, 33 mesenchymal chondrosarcomas, and 39 clear cell chondrosarcomas. Polymerase chain reaction single-stranded conformation polymorphism and sequencing analyses were done. No Bcl10 mutations were found in our series of malignant chondrogenic tumors. While screening for mutations, we also found three polymorphisms at codons 8 exon 1 of the Bcl10 gene. Our results strongly suggest that somatic mutations of Bcl10 are extremely rare in malignant cartilaginous tumors and do not commonly contribute to their molecular pathogenesis.

AB - The Bcl10 gene was recently isolated from the breakpoint region of t(1;14)(p22;q32) in mucosa-associated lymphoid tissue (MALT) lymphomas. Somatic mutations of Bcl10 were found in not only t(1;14)-bearing MALT lymphomas, but also a wide range of other tumors. To clarify the actual frequency and spectrum of Bcl10 mutations in primary malignant chondrogenic tumors, we examined 89 cases of malignant chondrogenic tumors comprising 17 conventional chondrosarcomas, 33 mesenchymal chondrosarcomas, and 39 clear cell chondrosarcomas. Polymerase chain reaction single-stranded conformation polymorphism and sequencing analyses were done. No Bcl10 mutations were found in our series of malignant chondrogenic tumors. While screening for mutations, we also found three polymorphisms at codons 8 exon 1 of the Bcl10 gene. Our results strongly suggest that somatic mutations of Bcl10 are extremely rare in malignant cartilaginous tumors and do not commonly contribute to their molecular pathogenesis.

UR - http://www.scopus.com/inward/record.url?scp=0036511711&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036511711&partnerID=8YFLogxK

M3 - Article

C2 - 11836626

AN - SCOPUS:0036511711

VL - 9

SP - 217

EP - 219

JO - International Journal of Molecular Medicine

JF - International Journal of Molecular Medicine

SN - 1107-3756

IS - 3

ER -