Lactobacillus-fermented milk products attenuate bone loss in an experimental rat model of ovariectomy-induced post-menopausal primary osteoporosis

C. S. Lee; J. Y. Kim; B. K. Kim; I. O. Lee; N. H. Park; S. H. Kim

doi:10.1111/jam.14852

Lactobacillus-fermented milk products attenuate bone loss in an experimental rat model of ovariectomy-induced post-menopausal primary osteoporosis

C. S. Lee, J. Y. Kim, B. K. Kim, I. O. Lee, N. H. Park, S. H. Kim

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Aim: In this study, we investigated the anti-osteoporotic effect of two fermented milk products (FMPs) fermented by Lactobacillus plantarum A41 and Lactobacillus fermentum SRK414 on a rat model of ovariectomy-induced post-menopausal primary osteoporosis. Methods and Results: The two Lactobacillus FMPs increased the bone volume and bone mineral density (BMD) in ovariectomized (OVX) rats, and normalized the bone biomarkers in the serum. Additionally, they altered the gene expression levels of bone-metabolism-related markers. Furthermore, the two Lactobacillus FMPs downregulated bone-apoptosis-related genes stimulated by ovariectomy. Interestingly, the Lactobacillus FMPs decreased the levels of inflammation markers in the serum, bone, ileum and colon of the rats. Gut bacterial populations were also affected upon FMP treatment due to increase in the abundance of the genus Lactobacillus and Faecalibacterium prausnitzii. Conclusions: Milk products fermented by L. plantarum A41 and L. fermentum SRK414 can exhibit anti-osteoporotic effects on post-menopausal osteoporosis via regulating the expression of bone-metabolism-related markers. Significance and Impact of the Study: The two Lactobacillus FMPs used in the study can be an ideal method that has its potential of treating post-menopausal osteoporosis instead of drug treatments.

Original language	English
Pages (from-to)	2041-2062
Number of pages	22
Journal	Journal of Applied Microbiology
Volume	130
Issue number	6
DOIs	https://doi.org/10.1111/jam.14852
Publication status	Published - 2021 Jun

Keywords

Lactobacillus
fermented foods
gene expression
lactic acid bacteria
osteoporosis
probiotics

ASJC Scopus subject areas

Biotechnology
Applied Microbiology and Biotechnology

Access to Document

10.1111/jam.14852

Cite this

@article{ed5860f3fc20491dba55198dcc028a69,

title = "Lactobacillus-fermented milk products attenuate bone loss in an experimental rat model of ovariectomy-induced post-menopausal primary osteoporosis",

abstract = "Aim: In this study, we investigated the anti-osteoporotic effect of two fermented milk products (FMPs) fermented by Lactobacillus plantarum A41 and Lactobacillus fermentum SRK414 on a rat model of ovariectomy-induced post-menopausal primary osteoporosis. Methods and Results: The two Lactobacillus FMPs increased the bone volume and bone mineral density (BMD) in ovariectomized (OVX) rats, and normalized the bone biomarkers in the serum. Additionally, they altered the gene expression levels of bone-metabolism-related markers. Furthermore, the two Lactobacillus FMPs downregulated bone-apoptosis-related genes stimulated by ovariectomy. Interestingly, the Lactobacillus FMPs decreased the levels of inflammation markers in the serum, bone, ileum and colon of the rats. Gut bacterial populations were also affected upon FMP treatment due to increase in the abundance of the genus Lactobacillus and Faecalibacterium prausnitzii. Conclusions: Milk products fermented by L. plantarum A41 and L. fermentum SRK414 can exhibit anti-osteoporotic effects on post-menopausal osteoporosis via regulating the expression of bone-metabolism-related markers. Significance and Impact of the Study: The two Lactobacillus FMPs used in the study can be an ideal method that has its potential of treating post-menopausal osteoporosis instead of drug treatments.",

keywords = "Lactobacillus, fermented foods, gene expression, lactic acid bacteria, osteoporosis, probiotics",

author = "Lee, {C. S.} and Kim, {J. Y.} and Kim, {B. K.} and Lee, {I. O.} and Park, {N. H.} and Kim, {S. H.}",

note = "Funding Information: This work was supported by the High Value-Added Food Technology Development Program of the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (iPET), Ministry for Food, Agriculture, Forestry and Fisheries of Republic of Korea (117051-03-3-HD020), and a Korea University Grant. Funding Information: This work was supported by the High Value‐Added Food Technology Development Program of the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (iPET), Ministry for Food, Agriculture, Forestry and Fisheries of Republic of Korea (117051‐03‐3‐HD020), and a Korea University Grant. Publisher Copyright: {\textcopyright} 2020 The Society for Applied Microbiology",

year = "2021",

month = jun,

doi = "10.1111/jam.14852",

language = "English",

volume = "130",

pages = "2041--2062",

journal = "Proceedings of the Society for Applied Bacteriology",

issn = "1364-5072",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "6",

}

TY - JOUR

T1 - Lactobacillus-fermented milk products attenuate bone loss in an experimental rat model of ovariectomy-induced post-menopausal primary osteoporosis

AU - Lee, C. S.

AU - Kim, J. Y.

AU - Kim, B. K.

AU - Lee, I. O.

AU - Park, N. H.

AU - Kim, S. H.

N1 - Funding Information: This work was supported by the High Value-Added Food Technology Development Program of the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (iPET), Ministry for Food, Agriculture, Forestry and Fisheries of Republic of Korea (117051-03-3-HD020), and a Korea University Grant. Funding Information: This work was supported by the High Value‐Added Food Technology Development Program of the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (iPET), Ministry for Food, Agriculture, Forestry and Fisheries of Republic of Korea (117051‐03‐3‐HD020), and a Korea University Grant. Publisher Copyright: © 2020 The Society for Applied Microbiology

PY - 2021/6

Y1 - 2021/6

N2 - Aim: In this study, we investigated the anti-osteoporotic effect of two fermented milk products (FMPs) fermented by Lactobacillus plantarum A41 and Lactobacillus fermentum SRK414 on a rat model of ovariectomy-induced post-menopausal primary osteoporosis. Methods and Results: The two Lactobacillus FMPs increased the bone volume and bone mineral density (BMD) in ovariectomized (OVX) rats, and normalized the bone biomarkers in the serum. Additionally, they altered the gene expression levels of bone-metabolism-related markers. Furthermore, the two Lactobacillus FMPs downregulated bone-apoptosis-related genes stimulated by ovariectomy. Interestingly, the Lactobacillus FMPs decreased the levels of inflammation markers in the serum, bone, ileum and colon of the rats. Gut bacterial populations were also affected upon FMP treatment due to increase in the abundance of the genus Lactobacillus and Faecalibacterium prausnitzii. Conclusions: Milk products fermented by L. plantarum A41 and L. fermentum SRK414 can exhibit anti-osteoporotic effects on post-menopausal osteoporosis via regulating the expression of bone-metabolism-related markers. Significance and Impact of the Study: The two Lactobacillus FMPs used in the study can be an ideal method that has its potential of treating post-menopausal osteoporosis instead of drug treatments.

AB - Aim: In this study, we investigated the anti-osteoporotic effect of two fermented milk products (FMPs) fermented by Lactobacillus plantarum A41 and Lactobacillus fermentum SRK414 on a rat model of ovariectomy-induced post-menopausal primary osteoporosis. Methods and Results: The two Lactobacillus FMPs increased the bone volume and bone mineral density (BMD) in ovariectomized (OVX) rats, and normalized the bone biomarkers in the serum. Additionally, they altered the gene expression levels of bone-metabolism-related markers. Furthermore, the two Lactobacillus FMPs downregulated bone-apoptosis-related genes stimulated by ovariectomy. Interestingly, the Lactobacillus FMPs decreased the levels of inflammation markers in the serum, bone, ileum and colon of the rats. Gut bacterial populations were also affected upon FMP treatment due to increase in the abundance of the genus Lactobacillus and Faecalibacterium prausnitzii. Conclusions: Milk products fermented by L. plantarum A41 and L. fermentum SRK414 can exhibit anti-osteoporotic effects on post-menopausal osteoporosis via regulating the expression of bone-metabolism-related markers. Significance and Impact of the Study: The two Lactobacillus FMPs used in the study can be an ideal method that has its potential of treating post-menopausal osteoporosis instead of drug treatments.

KW - Lactobacillus

KW - fermented foods

KW - gene expression

KW - lactic acid bacteria

KW - osteoporosis

KW - probiotics

UR - http://www.scopus.com/inward/record.url?scp=85096788160&partnerID=8YFLogxK

U2 - 10.1111/jam.14852

DO - 10.1111/jam.14852

M3 - Article

C2 - 32920885

AN - SCOPUS:85096788160

SN - 1364-5072

VL - 130

SP - 2041

EP - 2062

JO - Proceedings of the Society for Applied Bacteriology

JF - Proceedings of the Society for Applied Bacteriology

IS - 6

ER -

Lactobacillus-fermented milk products attenuate bone loss in an experimental rat model of ovariectomy-induced post-menopausal primary osteoporosis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this