Lamb wave-based blood coagulation test

Jeonghun Nam, Hyunjoo Choi, Jae Young Kim, Woongsik Jang, Chae Seung Lim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Blood coagulation tests are a critical part in diagnosis of patients with bleeding disorders and cardiovascular diseases. However, most conventional blood coagulation tests require large and expensive instruments and skilled personnel. Here, we present a simple and low-cost approach to evaluate blood coagulation using Lamb wave-based device. To assess coagulation, we monitored the acoustic streaming of 5 μm fluorescent particles suspended in citrated plasma. Using a Lamb wave, citrated blood plasma and coagulation reagents can be mixed in a few seconds and the viscosity of the droplet increases due to blood coagulation. Then, the acoustic streaming of particles eventually stops, at which the “coagulation time” is defined. As a preliminary test, coagulation time was reduced with increasing calcium concentration from 0 to 25 mM. Prothrombin time results from the Lamb wave-based device were validated by comparing with those of commercial instruments with the correlation coefficient (R2) as 0.9432. Using the Lamb wave for blood coagulation test, the temperature can be controlled as 37 °C simultaneously by modulating experimental conditions. Our device enables lithography-free, simple and low-cost measurement of blood coagulation, which can be applied to clinical settings and developing countries.

Original languageEnglish
Pages (from-to)190-195
Number of pages6
JournalSensors and Actuators, B: Chemical
Volume263
DOIs
Publication statusPublished - 2018 Jun 15

Keywords

  • Blood coagulation
  • Calcium solution
  • Lamb wave
  • Prothrombin time

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

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