Laminarin From Salicornia herbacea Stimulates Glucose Uptake Through AMPK-p38 MAPK Pathways in L6 Muscle Cells

Ji H. Kim; Jung O. Lee; Ji W. Moon; Min J. Kang; Won S. Byun; Jeong A. Han; Su J. Kim; Sun H. Park; Hyeon S. Kim

doi:10.1177/1934578X20901409

Laminarin From Salicornia herbacea Stimulates Glucose Uptake Through AMPK-p38 MAPK Pathways in L6 Muscle Cells

Ji H. Kim, Jung O. Lee, Ji W. Moon, Min J. Kang, Won S. Byun, Jeong A. Han, Su J. Kim, Sun H. Park, Hyeon S. Kim

Research output: Contribution to journal › Article › peer-review

Abstract

Laminarin is a component of brown seaweed, especially isolated from Salicornia herbacea. Laminarin was known to have various physiological functions, however, the molecular mechanism is still unclear. In this study, we report that laminarin stimulates an activation of AMP-activated protein kinase (AMPK) and increases glucose uptake in rat L6 myotubes. Laminarin also increases an intracellular calcium release. Inhibition of Ca²⁺ release, using with CaMKK inhibitor, STO-609, blocked laminarin-induced AMPK activity, indicating that laminarin stimulated AMPK activity via calcium. In addition, laminarin activates p38 mitogen-activated protein kinase (MAPK) signaling pathways depending on AMPK activity. Moreover, the inhibition of either AMPK or p38 MAPK blocked laminarin-induced glucose uptake in rat L6 myotubes. Taken together, these results demonstrate that the hypoglycemic effect of laminarin is caused by its ability to activate AMPK-p38 MAPK pathways in skeletal muscles.

Original language	English
Journal	Natural Product Communications
Volume	15
Issue number	3
DOIs	https://doi.org/10.1177/1934578X20901409
Publication status	Published - 2020

Keywords

AMPK
bioactivity
diabetes
glucose
laminarin
p38 MAPK

ASJC Scopus subject areas

Pharmacology
Plant Science
Drug Discovery
Complementary and alternative medicine

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@article{7174941e7a9a49b391471f4934d3ff3e,

title = "Laminarin From Salicornia herbacea Stimulates Glucose Uptake Through AMPK-p38 MAPK Pathways in L6 Muscle Cells",

abstract = "Laminarin is a component of brown seaweed, especially isolated from Salicornia herbacea. Laminarin was known to have various physiological functions, however, the molecular mechanism is still unclear. In this study, we report that laminarin stimulates an activation of AMP-activated protein kinase (AMPK) and increases glucose uptake in rat L6 myotubes. Laminarin also increases an intracellular calcium release. Inhibition of Ca2+ release, using with CaMKK inhibitor, STO-609, blocked laminarin-induced AMPK activity, indicating that laminarin stimulated AMPK activity via calcium. In addition, laminarin activates p38 mitogen-activated protein kinase (MAPK) signaling pathways depending on AMPK activity. Moreover, the inhibition of either AMPK or p38 MAPK blocked laminarin-induced glucose uptake in rat L6 myotubes. Taken together, these results demonstrate that the hypoglycemic effect of laminarin is caused by its ability to activate AMPK-p38 MAPK pathways in skeletal muscles.",

keywords = "AMPK, bioactivity, diabetes, glucose, laminarin, p38 MAPK",

author = "Kim, {Ji H.} and Lee, {Jung O.} and Moon, {Ji W.} and Kang, {Min J.} and Byun, {Won S.} and Han, {Jeong A.} and Kim, {Su J.} and Park, {Sun H.} and Kim, {Hyeon S.}",

note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by the Ministry of Oceans and Fisheries, Korea (KIMST, 2019R1707173).",

year = "2020",

doi = "10.1177/1934578X20901409",

language = "English",

volume = "15",

journal = "Natural Product Communications",

issn = "1934-578X",

publisher = "Natural Product Communications",

number = "3",

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TY - JOUR

T1 - Laminarin From Salicornia herbacea Stimulates Glucose Uptake Through AMPK-p38 MAPK Pathways in L6 Muscle Cells

AU - Kim, Ji H.

AU - Lee, Jung O.

AU - Moon, Ji W.

AU - Kang, Min J.

AU - Byun, Won S.

AU - Han, Jeong A.

AU - Kim, Su J.

AU - Park, Sun H.

AU - Kim, Hyeon S.

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by the Ministry of Oceans and Fisheries, Korea (KIMST, 2019R1707173).

PY - 2020

Y1 - 2020

N2 - Laminarin is a component of brown seaweed, especially isolated from Salicornia herbacea. Laminarin was known to have various physiological functions, however, the molecular mechanism is still unclear. In this study, we report that laminarin stimulates an activation of AMP-activated protein kinase (AMPK) and increases glucose uptake in rat L6 myotubes. Laminarin also increases an intracellular calcium release. Inhibition of Ca2+ release, using with CaMKK inhibitor, STO-609, blocked laminarin-induced AMPK activity, indicating that laminarin stimulated AMPK activity via calcium. In addition, laminarin activates p38 mitogen-activated protein kinase (MAPK) signaling pathways depending on AMPK activity. Moreover, the inhibition of either AMPK or p38 MAPK blocked laminarin-induced glucose uptake in rat L6 myotubes. Taken together, these results demonstrate that the hypoglycemic effect of laminarin is caused by its ability to activate AMPK-p38 MAPK pathways in skeletal muscles.

AB - Laminarin is a component of brown seaweed, especially isolated from Salicornia herbacea. Laminarin was known to have various physiological functions, however, the molecular mechanism is still unclear. In this study, we report that laminarin stimulates an activation of AMP-activated protein kinase (AMPK) and increases glucose uptake in rat L6 myotubes. Laminarin also increases an intracellular calcium release. Inhibition of Ca2+ release, using with CaMKK inhibitor, STO-609, blocked laminarin-induced AMPK activity, indicating that laminarin stimulated AMPK activity via calcium. In addition, laminarin activates p38 mitogen-activated protein kinase (MAPK) signaling pathways depending on AMPK activity. Moreover, the inhibition of either AMPK or p38 MAPK blocked laminarin-induced glucose uptake in rat L6 myotubes. Taken together, these results demonstrate that the hypoglycemic effect of laminarin is caused by its ability to activate AMPK-p38 MAPK pathways in skeletal muscles.

KW - AMPK

KW - bioactivity

KW - diabetes

KW - glucose

KW - laminarin

KW - p38 MAPK

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