Lanostane Triterpenes Isolated from Antrodia heteromorpha and Their Inhibitory Effects on RANKL-Induced Osteoclastogenesis

Jaeyoung Kwon, Hyaemin Lee, Yeo Dae Yoon, Bang Yeon Hwang, Yuanqiang Guo, Jong Soon Kang, Jae-Jin Kim, Dongho Lee

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Two new spiro-lanostane triterpenoids, antrolactones A and B (1 and 2), along with polyporenic acid C (3), were isolated from an EtOAc-soluble extract of Antrodia heteromorpha culture medium, and the chemical structures of the new compounds were elucidated by application of NMR, MS, and ECD spectroscopic techniques. All isolated compounds exhibited inhibitory effects on receptor activator of nuclear factor-kappaB ligand-induced osteoclastogenesis.

Original languageEnglish
Pages (from-to)1689-1693
Number of pages5
JournalJournal of Natural Products
Volume79
Issue number6
DOIs
Publication statusPublished - 2016 Jun 24

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Analytical Chemistry
  • Organic Chemistry
  • Molecular Medicine
  • Complementary and alternative medicine

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