Abstract
The worldwide spread of coronavirus disease (COVID-19) has become a threat to global public health. It is of great importance to rapidly and accurately screen and distinguish patients with COVID-19 from those with community-acquired pneumonia (CAP). In this study, a total of 1,658 patients with COVID-19 and 1,027 CAP patients underwent thin-section CT and were enrolled. All images were preprocessed to obtain the segmentations of infections and lung fields. A set of handcrafted location-specific features was proposed to best capture the COVID-19 distribution pattern, in comparison to the conventional CT severity score (CT-SS) and radiomics features. An infection size-aware random forest method (iSARF) was proposed for discriminating COVID-19 from CAP. Experimental results show that the proposed method yielded its best performance when using the handcrafted features, with a sensitivity of 90.7%, a specificity of 87.2%, and an accuracy of 89.4% over state-of-the-art classifiers. Additional tests on 734 subjects, with thick slice images, demonstrates great generalizability. It is anticipated that our proposed framework could assist clinical decision making.
Original language | English |
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Article number | 065031 |
Journal | Physics in Medicine and Biology |
Volume | 66 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2021 Mar 21 |
Keywords
- COVID-19
- decision tree
- pneumonia
- random forest
- size-aware
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
- Radiology Nuclear Medicine and imaging