Large-scale synthesis of ultrathin manganese oxide nanoplates and their applications to T1 MRI contrast agents

Mihyun Park, Nohyun Lee, Seung Hong Choi, Kwangjin An, Seung Ho Yu, Jeong Hyun Kim, Seung Hae Kwon, Dokyoon Kim, Hyoungsu Kim, Sung Il Baek, Tae Young Ahn, Ok Kyu Park, Jae Sung Son, Yung Eun Sung, Young Woon Kim, Zhongwu Wang, Nicola Pinna, Taeghwan Hyeon

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67 Citations (Scopus)

Abstract

Lamellar structured ultrathin manganese oxide nanoplates have been synthesized from thermal decomposition of manganese(II) acetylacetonate in the presence of 2,3-dihydroxynaphthalene, which promoted two-dimensional (2-D) growth by acting not only as a strongly binding surfactant but also as a structure-directing agent. Ultrathin manganese oxide nanoplates with a thickness of about 1 nm were assembled into a lamellar structure, and the width of the nanoplates could be controlled from 8 to 70 nm by using various coordinating solvents. X-ray absorption near-edge structure (XANES) spectra at the Mn K edge clearly showed that the nanoplates are mainly composed of Mn(II) species with octahedral symmetry. These hydrophobic manganese oxide nanoplates were ligand-exchanged with amine-terminated poly(ethyleneglycol) to generate water-dispersible nanoplates and applied to T1 contrast agents for magnetic resonance imaging (MRI). They exhibited a very high longitudinal relaxivity (r1) value of up to 5.5 mM-1s-1 derived from their high concentration of manganese ions exposed on the surface, and strong contrast enhancement of in vitro and in vivo MR images was observed with a very low dose.

Original languageEnglish
Pages (from-to)3318-3324
Number of pages7
JournalChemistry of Materials
Volume23
Issue number14
DOIs
Publication statusPublished - 2011 Jul 26
Externally publishedYes

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Keywords

  • contrast agent
  • magnetic resonance imaging
  • manganese oxide
  • nanoplates
  • π-π interactions

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Materials Chemistry

Cite this

Park, M., Lee, N., Choi, S. H., An, K., Yu, S. H., Kim, J. H., Kwon, S. H., Kim, D., Kim, H., Baek, S. I., Ahn, T. Y., Park, O. K., Son, J. S., Sung, Y. E., Kim, Y. W., Wang, Z., Pinna, N., & Hyeon, T. (2011). Large-scale synthesis of ultrathin manganese oxide nanoplates and their applications to T1 MRI contrast agents. Chemistry of Materials, 23(14), 3318-3324. https://doi.org/10.1021/cm200414c