Abstract
Background: Left atrial appendage (LAA) is an important source of thromboembolism in patients with atrial fibrillation (AF). This study evaluated the features of LAA associated with stroke in patients with AF. Methods: We compared the size of LAA using computed tomography (CT) between 224 AF patients with non-hemorrhagic stroke (Group 1, 71 women, age 67± 10 years) and 365 AF patients without stroke (Group 2, 77 women, age 56 ±11 years). Results: Group 1 included more female patients (31.7% vs. 21.1%, p=0.004), and was older than group 2 (p<0.001). There was no difference in the type of AF between two groups. CHADS2 score (3.2 ±0.8, vs. 0.6±0.7, p<0.001) and LA dimension (4.76±0.82 vs. 4.12±0.59 cm, p<0.001) were significantly lager in group 1 than group 2. The orifice size (3.85± 1.66 vs. 2.57±0.93 cm2, p<0.001) and depth of LAA (3.18±0.67 vs. 2.67±0.57 cm, p<0.001) were significantly larger in group 1 than group 2. In multivariate analysis, age (OR 2.08 per decade increase, 95% CI 1.59-2.71, p<0.001), LA size (OR 1.89, 95% CI 1.29-2.76, p=0.001), the orifice size (OR 1.58, 95% CI 1.26-1.99, p<0.001) and the depth of LAA (OR 1.91, 95% CI 1.24-2.95, p=0.004) were independent predictors of stroke. Conclusion: In patients with non-valvular atrial fibrillation, the larger orifice size and depth of LAA were independent predictors of stroke with advanced age and LA enlargement.
| Original language | English |
|---|---|
| Number of pages | 1 |
| Journal | Journal of Arrhythmia |
| Volume | 27 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2011 Jan 1 |
| Externally published | Yes |
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Keywords
- atrial fibrillation
- computed tomography
- stroke
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Larger Left Atrial Appendage Is an Independent Predictor of Stroke in Patients with Atrial Fibrillation. / Shim, Jaemin; Hwang, Hye Jin; Pak, Hui Nam; Lee, Moon Hyoung; Joung, Boyoung.
In: Journal of Arrhythmia, Vol. 27, No. 4, 01.01.2011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Larger Left Atrial Appendage Is an Independent Predictor of Stroke in Patients with Atrial Fibrillation
AU - Shim, Jaemin
AU - Hwang, Hye Jin
AU - Pak, Hui Nam
AU - Lee, Moon Hyoung
AU - Joung, Boyoung
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Background: Left atrial appendage (LAA) is an important source of thromboembolism in patients with atrial fibrillation (AF). This study evaluated the features of LAA associated with stroke in patients with AF. Methods: We compared the size of LAA using computed tomography (CT) between 224 AF patients with non-hemorrhagic stroke (Group 1, 71 women, age 67± 10 years) and 365 AF patients without stroke (Group 2, 77 women, age 56 ±11 years). Results: Group 1 included more female patients (31.7% vs. 21.1%, p=0.004), and was older than group 2 (p<0.001). There was no difference in the type of AF between two groups. CHADS2 score (3.2 ±0.8, vs. 0.6±0.7, p<0.001) and LA dimension (4.76±0.82 vs. 4.12±0.59 cm, p<0.001) were significantly lager in group 1 than group 2. The orifice size (3.85± 1.66 vs. 2.57±0.93 cm2, p<0.001) and depth of LAA (3.18±0.67 vs. 2.67±0.57 cm, p<0.001) were significantly larger in group 1 than group 2. In multivariate analysis, age (OR 2.08 per decade increase, 95% CI 1.59-2.71, p<0.001), LA size (OR 1.89, 95% CI 1.29-2.76, p=0.001), the orifice size (OR 1.58, 95% CI 1.26-1.99, p<0.001) and the depth of LAA (OR 1.91, 95% CI 1.24-2.95, p=0.004) were independent predictors of stroke. Conclusion: In patients with non-valvular atrial fibrillation, the larger orifice size and depth of LAA were independent predictors of stroke with advanced age and LA enlargement.
AB - Background: Left atrial appendage (LAA) is an important source of thromboembolism in patients with atrial fibrillation (AF). This study evaluated the features of LAA associated with stroke in patients with AF. Methods: We compared the size of LAA using computed tomography (CT) between 224 AF patients with non-hemorrhagic stroke (Group 1, 71 women, age 67± 10 years) and 365 AF patients without stroke (Group 2, 77 women, age 56 ±11 years). Results: Group 1 included more female patients (31.7% vs. 21.1%, p=0.004), and was older than group 2 (p<0.001). There was no difference in the type of AF between two groups. CHADS2 score (3.2 ±0.8, vs. 0.6±0.7, p<0.001) and LA dimension (4.76±0.82 vs. 4.12±0.59 cm, p<0.001) were significantly lager in group 1 than group 2. The orifice size (3.85± 1.66 vs. 2.57±0.93 cm2, p<0.001) and depth of LAA (3.18±0.67 vs. 2.67±0.57 cm, p<0.001) were significantly larger in group 1 than group 2. In multivariate analysis, age (OR 2.08 per decade increase, 95% CI 1.59-2.71, p<0.001), LA size (OR 1.89, 95% CI 1.29-2.76, p=0.001), the orifice size (OR 1.58, 95% CI 1.26-1.99, p<0.001) and the depth of LAA (OR 1.91, 95% CI 1.24-2.95, p=0.004) were independent predictors of stroke. Conclusion: In patients with non-valvular atrial fibrillation, the larger orifice size and depth of LAA were independent predictors of stroke with advanced age and LA enlargement.
KW - atrial fibrillation
KW - computed tomography
KW - stroke
UR - http://www.scopus.com/inward/record.url?scp=85009573414&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009573414&partnerID=8YFLogxK
U2 - 10.4020/jhrs.27.OP21_4
DO - 10.4020/jhrs.27.OP21_4
M3 - Article
AN - SCOPUS:85009573414
VL - 27
JO - Journal of Arrhythmia
JF - Journal of Arrhythmia
SN - 1880-4276
IS - 4
ER -