Larger Left Atrial Appendage Is an Independent Predictor of Stroke in Patients with Atrial Fibrillation

Jaemin Shim, Hye Jin Hwang, Hui Nam Pak, Moon Hyoung Lee, Boyoung Joung

Research output: Contribution to journalArticle

Abstract

Background: Left atrial appendage (LAA) is an important source of thromboembolism in patients with atrial fibrillation (AF). This study evaluated the features of LAA associated with stroke in patients with AF. Methods: We compared the size of LAA using computed tomography (CT) between 224 AF patients with non-hemorrhagic stroke (Group 1, 71 women, age 67± 10 years) and 365 AF patients without stroke (Group 2, 77 women, age 56 ±11 years). Results: Group 1 included more female patients (31.7% vs. 21.1%, p=0.004), and was older than group 2 (p<0.001). There was no difference in the type of AF between two groups. CHADS2 score (3.2 ±0.8, vs. 0.6±0.7, p<0.001) and LA dimension (4.76±0.82 vs. 4.12±0.59 cm, p<0.001) were significantly lager in group 1 than group 2. The orifice size (3.85± 1.66 vs. 2.57±0.93 cm2, p<0.001) and depth of LAA (3.18±0.67 vs. 2.67±0.57 cm, p<0.001) were significantly larger in group 1 than group 2. In multivariate analysis, age (OR 2.08 per decade increase, 95% CI 1.59-2.71, p<0.001), LA size (OR 1.89, 95% CI 1.29-2.76, p=0.001), the orifice size (OR 1.58, 95% CI 1.26-1.99, p<0.001) and the depth of LAA (OR 1.91, 95% CI 1.24-2.95, p=0.004) were independent predictors of stroke. Conclusion: In patients with non-valvular atrial fibrillation, the larger orifice size and depth of LAA were independent predictors of stroke with advanced age and LA enlargement.

Original languageEnglish
Number of pages1
JournalJournal of Arrhythmia
Volume27
Issue number4
DOIs
Publication statusPublished - 2011 Jan 1
Externally publishedYes

Fingerprint

Atrial Appendage
Atrial Fibrillation
Stroke
Thromboembolism
Multivariate Analysis
Tomography

Keywords

  • atrial fibrillation
  • computed tomography
  • stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Larger Left Atrial Appendage Is an Independent Predictor of Stroke in Patients with Atrial Fibrillation. / Shim, Jaemin; Hwang, Hye Jin; Pak, Hui Nam; Lee, Moon Hyoung; Joung, Boyoung.

In: Journal of Arrhythmia, Vol. 27, No. 4, 01.01.2011.

Research output: Contribution to journalArticle

Shim, Jaemin ; Hwang, Hye Jin ; Pak, Hui Nam ; Lee, Moon Hyoung ; Joung, Boyoung. / Larger Left Atrial Appendage Is an Independent Predictor of Stroke in Patients with Atrial Fibrillation. In: Journal of Arrhythmia. 2011 ; Vol. 27, No. 4.
@article{a94185dbf3094aff8b488b210909b403,
title = "Larger Left Atrial Appendage Is an Independent Predictor of Stroke in Patients with Atrial Fibrillation",
abstract = "Background: Left atrial appendage (LAA) is an important source of thromboembolism in patients with atrial fibrillation (AF). This study evaluated the features of LAA associated with stroke in patients with AF. Methods: We compared the size of LAA using computed tomography (CT) between 224 AF patients with non-hemorrhagic stroke (Group 1, 71 women, age 67± 10 years) and 365 AF patients without stroke (Group 2, 77 women, age 56 ±11 years). Results: Group 1 included more female patients (31.7{\%} vs. 21.1{\%}, p=0.004), and was older than group 2 (p<0.001). There was no difference in the type of AF between two groups. CHADS2 score (3.2 ±0.8, vs. 0.6±0.7, p<0.001) and LA dimension (4.76±0.82 vs. 4.12±0.59 cm, p<0.001) were significantly lager in group 1 than group 2. The orifice size (3.85± 1.66 vs. 2.57±0.93 cm2, p<0.001) and depth of LAA (3.18±0.67 vs. 2.67±0.57 cm, p<0.001) were significantly larger in group 1 than group 2. In multivariate analysis, age (OR 2.08 per decade increase, 95{\%} CI 1.59-2.71, p<0.001), LA size (OR 1.89, 95{\%} CI 1.29-2.76, p=0.001), the orifice size (OR 1.58, 95{\%} CI 1.26-1.99, p<0.001) and the depth of LAA (OR 1.91, 95{\%} CI 1.24-2.95, p=0.004) were independent predictors of stroke. Conclusion: In patients with non-valvular atrial fibrillation, the larger orifice size and depth of LAA were independent predictors of stroke with advanced age and LA enlargement.",
keywords = "atrial fibrillation, computed tomography, stroke",
author = "Jaemin Shim and Hwang, {Hye Jin} and Pak, {Hui Nam} and Lee, {Moon Hyoung} and Boyoung Joung",
year = "2011",
month = "1",
day = "1",
doi = "10.4020/jhrs.27.OP21_4",
language = "English",
volume = "27",
journal = "Journal of Arrhythmia",
issn = "1880-4276",
publisher = "Elsevier BV",
number = "4",

}

TY - JOUR

T1 - Larger Left Atrial Appendage Is an Independent Predictor of Stroke in Patients with Atrial Fibrillation

AU - Shim, Jaemin

AU - Hwang, Hye Jin

AU - Pak, Hui Nam

AU - Lee, Moon Hyoung

AU - Joung, Boyoung

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Background: Left atrial appendage (LAA) is an important source of thromboembolism in patients with atrial fibrillation (AF). This study evaluated the features of LAA associated with stroke in patients with AF. Methods: We compared the size of LAA using computed tomography (CT) between 224 AF patients with non-hemorrhagic stroke (Group 1, 71 women, age 67± 10 years) and 365 AF patients without stroke (Group 2, 77 women, age 56 ±11 years). Results: Group 1 included more female patients (31.7% vs. 21.1%, p=0.004), and was older than group 2 (p<0.001). There was no difference in the type of AF between two groups. CHADS2 score (3.2 ±0.8, vs. 0.6±0.7, p<0.001) and LA dimension (4.76±0.82 vs. 4.12±0.59 cm, p<0.001) were significantly lager in group 1 than group 2. The orifice size (3.85± 1.66 vs. 2.57±0.93 cm2, p<0.001) and depth of LAA (3.18±0.67 vs. 2.67±0.57 cm, p<0.001) were significantly larger in group 1 than group 2. In multivariate analysis, age (OR 2.08 per decade increase, 95% CI 1.59-2.71, p<0.001), LA size (OR 1.89, 95% CI 1.29-2.76, p=0.001), the orifice size (OR 1.58, 95% CI 1.26-1.99, p<0.001) and the depth of LAA (OR 1.91, 95% CI 1.24-2.95, p=0.004) were independent predictors of stroke. Conclusion: In patients with non-valvular atrial fibrillation, the larger orifice size and depth of LAA were independent predictors of stroke with advanced age and LA enlargement.

AB - Background: Left atrial appendage (LAA) is an important source of thromboembolism in patients with atrial fibrillation (AF). This study evaluated the features of LAA associated with stroke in patients with AF. Methods: We compared the size of LAA using computed tomography (CT) between 224 AF patients with non-hemorrhagic stroke (Group 1, 71 women, age 67± 10 years) and 365 AF patients without stroke (Group 2, 77 women, age 56 ±11 years). Results: Group 1 included more female patients (31.7% vs. 21.1%, p=0.004), and was older than group 2 (p<0.001). There was no difference in the type of AF between two groups. CHADS2 score (3.2 ±0.8, vs. 0.6±0.7, p<0.001) and LA dimension (4.76±0.82 vs. 4.12±0.59 cm, p<0.001) were significantly lager in group 1 than group 2. The orifice size (3.85± 1.66 vs. 2.57±0.93 cm2, p<0.001) and depth of LAA (3.18±0.67 vs. 2.67±0.57 cm, p<0.001) were significantly larger in group 1 than group 2. In multivariate analysis, age (OR 2.08 per decade increase, 95% CI 1.59-2.71, p<0.001), LA size (OR 1.89, 95% CI 1.29-2.76, p=0.001), the orifice size (OR 1.58, 95% CI 1.26-1.99, p<0.001) and the depth of LAA (OR 1.91, 95% CI 1.24-2.95, p=0.004) were independent predictors of stroke. Conclusion: In patients with non-valvular atrial fibrillation, the larger orifice size and depth of LAA were independent predictors of stroke with advanced age and LA enlargement.

KW - atrial fibrillation

KW - computed tomography

KW - stroke

UR - http://www.scopus.com/inward/record.url?scp=85009573414&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85009573414&partnerID=8YFLogxK

U2 - 10.4020/jhrs.27.OP21_4

DO - 10.4020/jhrs.27.OP21_4

M3 - Article

AN - SCOPUS:85009573414

VL - 27

JO - Journal of Arrhythmia

JF - Journal of Arrhythmia

SN - 1880-4276

IS - 4

ER -