Lateral displacement and conformation of DNA chains in abrupt 90° microbends

Jeong Yong Lee, Hyun Wook Jung, Jae Chun Hyun, Myung Suk Chun

Research output: Contribution to journalArticle

Abstract

The migration and conformation of a single λ-DNA chain in a microchannel with a 90 bend have been investigated using the hybrid numerical scheme of Brownian dynamics (BD) simulations and a CFD (computational fluid dynamics) solver, Flow-3D. A significant displacement of the single DNA chain was found after it had passed through the microbend and depended on its initial location. The λ-DNA chain initially positioned near the inner (or outer) wall migrated farther toward the inner (or outer) wall after passage through the bend. This is ascribed by the hydrodynamic features of the bulk flow field in the bend region. The relationship between an extension of the single chain and the flow characteristics was elucidated by changing the effective shear rate and the channel width.

Original languageEnglish
Pages (from-to)125-131
Number of pages7
JournalJournal of the Korean Physical Society
Volume58
Issue number1
DOIs
Publication statusPublished - 2011 Jan 14

Keywords

  • λ-DNA molecule
  • Brownian dynamics
  • Conformation
  • Microbends
  • Migration
  • References

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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