Lathyrane-Type Diterpenoids from the Seeds of Euphorbia lathyris L. with Inhibitory Effects on NO Production in RAW 264.7 Cells

Jin Woo Lee, Qinghao Jin, Hari Jang, Jun Gu Kim, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticle

Abstract

Bioactivity-guided fractionation of the methanolic extract from the seeds of Euphorbia lathyris led to the isolation of 18 lathyrane-type diterpenoids including a new one, Euphorbia factor L29 (1). Their chemical structures were elucidated by extensive NMR spectroscopic data including 2D-NMR and HR-ESI-MS as well as CD data. All isolates (1 – 18) were found to inhibit the nitric oxide production in LPS-induced RAW 264.7 macrophages, with their IC50 values in the range of 11.2 – 52.2 μm.

Original languageEnglish
Article numbere1800144
JournalChemistry and Biodiversity
Volume15
Issue number10
DOIs
Publication statusPublished - 2018 Oct 1

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Keywords

  • anti-inflammatory activities
  • Euphorbia lathyris
  • Euphorbiaceae
  • lathyrane-type diterpenoids
  • nitric oxide

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology

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