Lathyrane-Type Diterpenoids from the Seeds of Euphorbia lathyris L. with Inhibitory Effects on NO Production in RAW 264.7 Cells

Jin Woo Lee, Qinghao Jin, Hari Jang, Jun Gu Kim, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticle

Abstract

Bioactivity-guided fractionation of the methanolic extract from the seeds of Euphorbia lathyris led to the isolation of 18 lathyrane-type diterpenoids including a new one, Euphorbia factor L29 (1). Their chemical structures were elucidated by extensive NMR spectroscopic data including 2D-NMR and HR-ESI-MS as well as CD data. All isolates (1 – 18) were found to inhibit the nitric oxide production in LPS-induced RAW 264.7 macrophages, with their IC50 values in the range of 11.2 – 52.2 μm.

Original languageEnglish
Article numbere1800144
JournalChemistry and Biodiversity
Volume15
Issue number10
DOIs
Publication statusPublished - 2018 Oct 1

Fingerprint

Euphorbia
Diterpenes
Seed
Seeds
Nuclear magnetic resonance
Macrophages
Nitric oxide
Fractionation
Bioactivity
Inhibitory Concentration 50
Nitric Oxide
lathyrane
RAW 264.7 Cells

Keywords

  • anti-inflammatory activities
  • Euphorbia lathyris
  • Euphorbiaceae
  • lathyrane-type diterpenoids
  • nitric oxide

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology

Cite this

Lathyrane-Type Diterpenoids from the Seeds of Euphorbia lathyris L. with Inhibitory Effects on NO Production in RAW 264.7 Cells. / Lee, Jin Woo; Jin, Qinghao; Jang, Hari; Kim, Jun Gu; Lee, Dongho; Kim, Youngsoo; Hong, Jin Tae; Lee, Mi Kyeong; Hwang, Bang Yeon.

In: Chemistry and Biodiversity, Vol. 15, No. 10, e1800144, 01.10.2018.

Research output: Contribution to journalArticle

Lee, Jin Woo ; Jin, Qinghao ; Jang, Hari ; Kim, Jun Gu ; Lee, Dongho ; Kim, Youngsoo ; Hong, Jin Tae ; Lee, Mi Kyeong ; Hwang, Bang Yeon. / Lathyrane-Type Diterpenoids from the Seeds of Euphorbia lathyris L. with Inhibitory Effects on NO Production in RAW 264.7 Cells. In: Chemistry and Biodiversity. 2018 ; Vol. 15, No. 10.
@article{c21bfcab68ef4fca9595ecc49be50de2,
title = "Lathyrane-Type Diterpenoids from the Seeds of Euphorbia lathyris L. with Inhibitory Effects on NO Production in RAW 264.7 Cells",
abstract = "Bioactivity-guided fractionation of the methanolic extract from the seeds of Euphorbia lathyris led to the isolation of 18 lathyrane-type diterpenoids including a new one, Euphorbia factor L29 (1). Their chemical structures were elucidated by extensive NMR spectroscopic data including 2D-NMR and HR-ESI-MS as well as CD data. All isolates (1 – 18) were found to inhibit the nitric oxide production in LPS-induced RAW 264.7 macrophages, with their IC50 values in the range of 11.2 – 52.2 μm.",
keywords = "anti-inflammatory activities, Euphorbia lathyris, Euphorbiaceae, lathyrane-type diterpenoids, nitric oxide",
author = "Lee, {Jin Woo} and Qinghao Jin and Hari Jang and Kim, {Jun Gu} and Dongho Lee and Youngsoo Kim and Hong, {Jin Tae} and Lee, {Mi Kyeong} and Hwang, {Bang Yeon}",
year = "2018",
month = "10",
day = "1",
doi = "10.1002/cbdv.201800144",
language = "English",
volume = "15",
journal = "Chemistry and Biodiversity",
issn = "1612-1872",
publisher = "Wiley-VCH Verlag",
number = "10",

}

TY - JOUR

T1 - Lathyrane-Type Diterpenoids from the Seeds of Euphorbia lathyris L. with Inhibitory Effects on NO Production in RAW 264.7 Cells

AU - Lee, Jin Woo

AU - Jin, Qinghao

AU - Jang, Hari

AU - Kim, Jun Gu

AU - Lee, Dongho

AU - Kim, Youngsoo

AU - Hong, Jin Tae

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Bioactivity-guided fractionation of the methanolic extract from the seeds of Euphorbia lathyris led to the isolation of 18 lathyrane-type diterpenoids including a new one, Euphorbia factor L29 (1). Their chemical structures were elucidated by extensive NMR spectroscopic data including 2D-NMR and HR-ESI-MS as well as CD data. All isolates (1 – 18) were found to inhibit the nitric oxide production in LPS-induced RAW 264.7 macrophages, with their IC50 values in the range of 11.2 – 52.2 μm.

AB - Bioactivity-guided fractionation of the methanolic extract from the seeds of Euphorbia lathyris led to the isolation of 18 lathyrane-type diterpenoids including a new one, Euphorbia factor L29 (1). Their chemical structures were elucidated by extensive NMR spectroscopic data including 2D-NMR and HR-ESI-MS as well as CD data. All isolates (1 – 18) were found to inhibit the nitric oxide production in LPS-induced RAW 264.7 macrophages, with their IC50 values in the range of 11.2 – 52.2 μm.

KW - anti-inflammatory activities

KW - Euphorbia lathyris

KW - Euphorbiaceae

KW - lathyrane-type diterpenoids

KW - nitric oxide

UR - http://www.scopus.com/inward/record.url?scp=85054359805&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054359805&partnerID=8YFLogxK

U2 - 10.1002/cbdv.201800144

DO - 10.1002/cbdv.201800144

M3 - Article

C2 - 30120899

AN - SCOPUS:85054359805

VL - 15

JO - Chemistry and Biodiversity

JF - Chemistry and Biodiversity

SN - 1612-1872

IS - 10

M1 - e1800144

ER -