Lathyrane-Type Diterpenoids from the Seeds of Euphorbia lathyris L. with Inhibitory Effects on NO Production in RAW 264.7 Cells

Jin Woo Lee; Qinghao Jin; Hari Jang; Jun Gu Kim; Dongho Lee; Youngsoo Kim; Jin Tae Hong; Mi Kyeong Lee; Bang Yeon Hwang

doi:10.1002/cbdv.201800144

Lathyrane-Type Diterpenoids from the Seeds of Euphorbia lathyris L. with Inhibitory Effects on NO Production in RAW 264.7 Cells

Jin Woo Lee, Qinghao Jin, Hari Jang, Jun Gu Kim, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

Division of Biotechnology

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Bioactivity-guided fractionation of the methanolic extract from the seeds of Euphorbia lathyris led to the isolation of 18 lathyrane-type diterpenoids including a new one, Euphorbia factor L₂₉ (1). Their chemical structures were elucidated by extensive NMR spectroscopic data including 2D-NMR and HR-ESI-MS as well as CD data. All isolates (1 – 18) were found to inhibit the nitric oxide production in LPS-induced RAW 264.7 macrophages, with their IC₅₀ values in the range of 11.2 – 52.2 μm.

Original language	English
Article number	e1800144
Journal	Chemistry and Biodiversity
Volume	15
Issue number	10
DOIs	https://doi.org/10.1002/cbdv.201800144
Publication status	Published - 2018 Oct 1

Keywords

anti-inflammatory activities
Euphorbia lathyris
Euphorbiaceae
lathyrane-type diterpenoids
nitric oxide

ASJC Scopus subject areas

Bioengineering
Biochemistry
Chemistry(all)
Molecular Medicine
Molecular Biology

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10.1002/cbdv.201800144

Cite this

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title = "Lathyrane-Type Diterpenoids from the Seeds of Euphorbia lathyris L. with Inhibitory Effects on NO Production in RAW 264.7 Cells",

abstract = "Bioactivity-guided fractionation of the methanolic extract from the seeds of Euphorbia lathyris led to the isolation of 18 lathyrane-type diterpenoids including a new one, Euphorbia factor L29 (1). Their chemical structures were elucidated by extensive NMR spectroscopic data including 2D-NMR and HR-ESI-MS as well as CD data. All isolates (1 – 18) were found to inhibit the nitric oxide production in LPS-induced RAW 264.7 macrophages, with their IC50 values in the range of 11.2 – 52.2 μm.",

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doi = "10.1002/cbdv.201800144",

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AU - Lee, Jin Woo

AU - Jin, Qinghao

AU - Jang, Hari

AU - Kim, Jun Gu

AU - Lee, Dongho

AU - Kim, Youngsoo

AU - Hong, Jin Tae

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

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AB - Bioactivity-guided fractionation of the methanolic extract from the seeds of Euphorbia lathyris led to the isolation of 18 lathyrane-type diterpenoids including a new one, Euphorbia factor L29 (1). Their chemical structures were elucidated by extensive NMR spectroscopic data including 2D-NMR and HR-ESI-MS as well as CD data. All isolates (1 – 18) were found to inhibit the nitric oxide production in LPS-induced RAW 264.7 macrophages, with their IC50 values in the range of 11.2 – 52.2 μm.

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Lathyrane-Type Diterpenoids from the Seeds of Euphorbia lathyris L. with Inhibitory Effects on NO Production in RAW 264.7 Cells

Abstract

Keywords

ASJC Scopus subject areas

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