Leaf-inspired homeostatic cellulose biosensors

Ji Yong Kim, Yong Ju Yun, Joshua Jeong, C. Yoon Kim, Klaus Robert Möller, Seong Whan Lee

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

An incompatibility between skin homeostasis and existing biosensor interfaces inhibits long-Term electrophysiological signal measurement. Inspired by the leaf homeostasis system, we developed the first homeostatic cellulose biosensor with functions of protection, sensation, self-regulation, and biosafety. Moreover, we find that a mesoporous cellulose membrane transforms into homeostatic material with properties that include high ion conductivity, excellent flexibility and stability, appropriate adhesion force, and self-healing effects when swollen in a saline solution. The proposed biosensor is found to maintain a stable skin-sensor interface through homeostasis even when challenged by various stresses, such as a dynamic environment, severe detachment, dense hair, sweat, and long-Term measurement. Last, we demonstrate the high usability of our homeostatic biosensor for continuous and stable measurement of electrophysiological signals and give a showcase application in the field of brain-computer interfacing where the biosensors and machine learning together help to control real-Time applications beyond the laboratory at unprecedented versatility.

Original languageEnglish
Article numbereabe7432
JournalScience Advances
Volume7
Issue number16
DOIs
Publication statusPublished - 2021 Apr 14

ASJC Scopus subject areas

  • General

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