Leaflet manual of external beam radiation therapy for hepatocellular carcinoma: A review of the indications, evidences, and clinical trials

Chai Hong Rim, Won Sup Yoon

    Research output: Contribution to journalReview articlepeer-review

    15 Citations (Scopus)

    Abstract

    The use of external beam radiation therapy (EBRT) in the treatment of hepatocellular carcinoma (HCC), which was rarely performed due to liver toxicity with a previous technique, has increased. Palliation of portal vein thrombosis, supplementation for insufficient transarterial chemoembolization, and provision of new curative opportunities using stereotactic body radiotherapy are the potential indications for use of EBRT. The mechanism of EBRT treatment, with its radiobiological and physical perspectives, differs from those of conventional medical treatment or surgery. Therefore, understanding the effects of EBRT may be unfamiliar to physicians other than radiation oncologists, especially in the field of HCC, where EBRT has recently begun to be applied. The first objective of this review was to concisely explain the indications for use of EBRT for HCC for all physicians treating HCC. Therefore, this review focuses on the therapeutic outcomes rather than the detailed biological and physical background. We also reviewed recent clinical trials that may extend the indications for use of EBRT. Finally, we reviewed the current clinical practice guidelines for the treatment of HCC and discuss the current recommendations and future perspectives.

    Original languageEnglish
    Pages (from-to)2865-2874
    Number of pages10
    JournalOncoTargets and Therapy
    Volume11
    DOIs
    Publication statusPublished - 2018 May 16

    Keywords

    • Clinical trials
    • External beam radiotherapy
    • Guidelines
    • Hepatocellular carcinoma
    • Liver neoplasm
    • Sorafenib
    • Stereotactic body radiotherapy

    ASJC Scopus subject areas

    • Oncology
    • Pharmacology (medical)

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