Left ventricular wall motion abnormalities are associated with stroke recurrence

Jeong Yoon Choi, Jaehyung Cha, Jin-Man Jung, Woo Keun Seo, Kyungmi Oh, Kyung-Hee Cho, Sungwook Yu

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13 Citations (Scopus)


Objective: To investigate the role of left ventricular wall motion abnormalities (LVWMA), unrelated to high-risk cardioembolic conditions, in stroke recurrence. Methods: This study included consecutive acute ischemic stroke patients. Transthoracic echocardiography was performed as a routine evaluation for stroke patients. The outcomes were the time to recurrent any stroke and ischemic stroke. Results: Among 4,316 acute ischemic stroke patients, 430 had LVWMA without high-risk cardioembolic sources. The median observation periods of patients at risk of any stroke and ischemic stroke were 24.5 and 24.7 months. During the follow-up, any stroke and ischemic stroke recurrence were observed in 310 (7.2%) and 250 (5.8%) patients. LVWMA were associated with outcomes after adjustment for traditional cardiovascular risk factors, laboratory and imaging variables, and therapeutic interventions (hazard ratio [HR] 1.707, 95% confidence interval [CI] 1.262-2.310 for any stroke; HR 1.709, 95% CI 1.222-2.390 for ischemic stroke). Moreover, LVWMA could still be considered as independent risk factors after correction for covariates that were significantly associated with outcomes in univariable regression (HR 1.747, 95% CI 1.292-2.364 for any stroke; HR 1.704, 95% CI 1.219-2.382 for ischemic stroke). There were no significant interactions between LVWMA and outcomes between the subgroups except for the statin treatment subgroup. Conclusions: This study suggests that LVWMA, even when unassociated with high-risk cardioembolic sources, could be an independent predictor for stroke recurrence in patients with ischemic stroke.

Original languageEnglish
Pages (from-to)586-594
Number of pages9
Issue number6
Publication statusPublished - 2017 Feb 7

ASJC Scopus subject areas

  • Clinical Neurology

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    Choi, J. Y., Cha, J., Jung, J-M., Seo, W. K., Oh, K., Cho, K-H., & Yu, S. (2017). Left ventricular wall motion abnormalities are associated with stroke recurrence. Neurology, 88(6), 586-594. https://doi.org/10.1212/WNL.0000000000003588