Lengthened cutaneous silent period in fibromyalgia suggesting central sensitization as a pathogenesis

Seol Hee Baek, Hung Youl Seok, Yong Seo Koo, Byung Jo Kim

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The pathogenesis of fibromyalgia (FM) has not been clearly elucidated, but central sensitization, which plays an important role in the development of neuropathic pain, is considered to be the main mechanism. The cutaneous silent period (CSP), which is a spinal reflex mediated by A-delta cutaneous afferents, is useful for the evaluation of sensorimotor integration at the spinal and supraspinal levels. To understand the pathophysiology of FM, we compared CSP patterns between patients with FM and normal healthy subjects. Twentyfour patients with FM diagnosed in accordance with the 1990 American College of Rheumatology classification system and 24 age- and sex-matched healthy volunteers were recruited. The CSP was measured from the abductor pollicis brevis muscle. Demographic data, number of tender points, and visual analog scale and FM impact questionnaire scores were collected. The measured CSP and clinical parameters of the patient and control groups were compared. In addition, possible correlations between the CSP parameters and the other clinical characteristics were analyzed. Mean CSP latencies did not differ between patients (55.50 ± 10.97 ms) and healthy controls (60.23 ± 11.87 ms; p = 0.158), although the mean CSP duration was significantly longer in patients (73.75 ± 15.67 ms) than in controls (63.50 ± 14.05 ms; p = 0.021). CSP variables did not correlate with any clinical variables. The significantly longer CSP duration in FM patients suggests central dysregulation at the spinal and supraspinal levels, rather than peripheral small fiber dysfunction.

Original languageEnglish
Article numbere0149248
JournalPLoS One
Volume11
Issue number2
DOIs
Publication statusPublished - 2016 Feb 1

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Central Nervous System Sensitization
Fibromyalgia
pathogenesis
Skin
Muscle
duration
Fibers
pathophysiology
reflexes
Healthy Volunteers
volunteers
pain
demographic statistics
questionnaires
Neuralgia
muscles
Visual Analog Scale
gender
Reflex
Demography

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Lengthened cutaneous silent period in fibromyalgia suggesting central sensitization as a pathogenesis. / Baek, Seol Hee; Seok, Hung Youl; Koo, Yong Seo; Kim, Byung Jo.

In: PLoS One, Vol. 11, No. 2, e0149248, 01.02.2016.

Research output: Contribution to journalArticle

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