Leptin in human physiology and therapeutics

Tina A. Dardeno, Sharon H. Chou, Hyun-Seuk Moon, John P. Chamberland, Christina G. Fiorenza, Christos S. Mantzoros

Research output: Contribution to journalArticle

163 Citations (Scopus)

Abstract

Leptin regulates energy homeostasis and reproductive, neuroendocrine, immune, and metabolic functions. In this review, we describe the role of leptin in human physiology and review evidence from recent " proof of concept" clinical trials using recombinant human leptin in subjects with congenital leptin deficiency, hypoleptinemia associated with energy-deficient states, and hyperleptinemia associated with garden-variety obesity. Since most obese individuals are largely leptin-tolerant or -resistant, therapeutic uses of leptin are currently limited to patients with complete or partial leptin deficiency, including hypothalamic amenorrhea and lipoatrophy. Leptin administration in these energy-deficient states may help restore associated neuroendocrine, metabolic, and immune function and bone metabolism. Leptin treatment is currently available for individuals with congenital leptin deficiency and congenital lipoatrophy. The long-term efficacy and safety of leptin treatment in hypothalamic amenorrhea and acquired lipoatrophy are currently under investigation. Whether combination therapy with leptin and potential leptin sensitizers will prove effective in the treatment of garden-variety obesity and whether leptin may have a role in weight loss maintenance is being greatly anticipated.

Original languageEnglish
Pages (from-to)377-393
Number of pages17
JournalFrontiers in Neuroendocrinology
Volume31
Issue number3
DOIs
Publication statusPublished - 2010 Jul 1
Externally publishedYes

Fingerprint

Leptin
Therapeutics
Amenorrhea
Obesity
Therapeutic Uses
Weight Loss
Homeostasis
Maintenance
Clinical Trials

Keywords

  • Adipokines
  • Amenorrhea
  • Energy homeostasis
  • Insulin resistance
  • Leptin
  • Leptin deficiency
  • Leptin resistance
  • Lipoatrophy
  • Obesity

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems

Cite this

Dardeno, T. A., Chou, S. H., Moon, H-S., Chamberland, J. P., Fiorenza, C. G., & Mantzoros, C. S. (2010). Leptin in human physiology and therapeutics. Frontiers in Neuroendocrinology, 31(3), 377-393. https://doi.org/10.1016/j.yfrne.2010.06.002

Leptin in human physiology and therapeutics. / Dardeno, Tina A.; Chou, Sharon H.; Moon, Hyun-Seuk; Chamberland, John P.; Fiorenza, Christina G.; Mantzoros, Christos S.

In: Frontiers in Neuroendocrinology, Vol. 31, No. 3, 01.07.2010, p. 377-393.

Research output: Contribution to journalArticle

Dardeno, TA, Chou, SH, Moon, H-S, Chamberland, JP, Fiorenza, CG & Mantzoros, CS 2010, 'Leptin in human physiology and therapeutics', Frontiers in Neuroendocrinology, vol. 31, no. 3, pp. 377-393. https://doi.org/10.1016/j.yfrne.2010.06.002
Dardeno TA, Chou SH, Moon H-S, Chamberland JP, Fiorenza CG, Mantzoros CS. Leptin in human physiology and therapeutics. Frontiers in Neuroendocrinology. 2010 Jul 1;31(3):377-393. https://doi.org/10.1016/j.yfrne.2010.06.002
Dardeno, Tina A. ; Chou, Sharon H. ; Moon, Hyun-Seuk ; Chamberland, John P. ; Fiorenza, Christina G. ; Mantzoros, Christos S. / Leptin in human physiology and therapeutics. In: Frontiers in Neuroendocrinology. 2010 ; Vol. 31, No. 3. pp. 377-393.
@article{fb35a774aeff48fabc8e40da3cdcbdf3,
title = "Leptin in human physiology and therapeutics",
abstract = "Leptin regulates energy homeostasis and reproductive, neuroendocrine, immune, and metabolic functions. In this review, we describe the role of leptin in human physiology and review evidence from recent {"} proof of concept{"} clinical trials using recombinant human leptin in subjects with congenital leptin deficiency, hypoleptinemia associated with energy-deficient states, and hyperleptinemia associated with garden-variety obesity. Since most obese individuals are largely leptin-tolerant or -resistant, therapeutic uses of leptin are currently limited to patients with complete or partial leptin deficiency, including hypothalamic amenorrhea and lipoatrophy. Leptin administration in these energy-deficient states may help restore associated neuroendocrine, metabolic, and immune function and bone metabolism. Leptin treatment is currently available for individuals with congenital leptin deficiency and congenital lipoatrophy. The long-term efficacy and safety of leptin treatment in hypothalamic amenorrhea and acquired lipoatrophy are currently under investigation. Whether combination therapy with leptin and potential leptin sensitizers will prove effective in the treatment of garden-variety obesity and whether leptin may have a role in weight loss maintenance is being greatly anticipated.",
keywords = "Adipokines, Amenorrhea, Energy homeostasis, Insulin resistance, Leptin, Leptin deficiency, Leptin resistance, Lipoatrophy, Obesity",
author = "Dardeno, {Tina A.} and Chou, {Sharon H.} and Hyun-Seuk Moon and Chamberland, {John P.} and Fiorenza, {Christina G.} and Mantzoros, {Christos S.}",
year = "2010",
month = "7",
day = "1",
doi = "10.1016/j.yfrne.2010.06.002",
language = "English",
volume = "31",
pages = "377--393",
journal = "Frontiers in Neuroendocrinology",
issn = "0091-3022",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Leptin in human physiology and therapeutics

AU - Dardeno, Tina A.

AU - Chou, Sharon H.

AU - Moon, Hyun-Seuk

AU - Chamberland, John P.

AU - Fiorenza, Christina G.

AU - Mantzoros, Christos S.

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Leptin regulates energy homeostasis and reproductive, neuroendocrine, immune, and metabolic functions. In this review, we describe the role of leptin in human physiology and review evidence from recent " proof of concept" clinical trials using recombinant human leptin in subjects with congenital leptin deficiency, hypoleptinemia associated with energy-deficient states, and hyperleptinemia associated with garden-variety obesity. Since most obese individuals are largely leptin-tolerant or -resistant, therapeutic uses of leptin are currently limited to patients with complete or partial leptin deficiency, including hypothalamic amenorrhea and lipoatrophy. Leptin administration in these energy-deficient states may help restore associated neuroendocrine, metabolic, and immune function and bone metabolism. Leptin treatment is currently available for individuals with congenital leptin deficiency and congenital lipoatrophy. The long-term efficacy and safety of leptin treatment in hypothalamic amenorrhea and acquired lipoatrophy are currently under investigation. Whether combination therapy with leptin and potential leptin sensitizers will prove effective in the treatment of garden-variety obesity and whether leptin may have a role in weight loss maintenance is being greatly anticipated.

AB - Leptin regulates energy homeostasis and reproductive, neuroendocrine, immune, and metabolic functions. In this review, we describe the role of leptin in human physiology and review evidence from recent " proof of concept" clinical trials using recombinant human leptin in subjects with congenital leptin deficiency, hypoleptinemia associated with energy-deficient states, and hyperleptinemia associated with garden-variety obesity. Since most obese individuals are largely leptin-tolerant or -resistant, therapeutic uses of leptin are currently limited to patients with complete or partial leptin deficiency, including hypothalamic amenorrhea and lipoatrophy. Leptin administration in these energy-deficient states may help restore associated neuroendocrine, metabolic, and immune function and bone metabolism. Leptin treatment is currently available for individuals with congenital leptin deficiency and congenital lipoatrophy. The long-term efficacy and safety of leptin treatment in hypothalamic amenorrhea and acquired lipoatrophy are currently under investigation. Whether combination therapy with leptin and potential leptin sensitizers will prove effective in the treatment of garden-variety obesity and whether leptin may have a role in weight loss maintenance is being greatly anticipated.

KW - Adipokines

KW - Amenorrhea

KW - Energy homeostasis

KW - Insulin resistance

KW - Leptin

KW - Leptin deficiency

KW - Leptin resistance

KW - Lipoatrophy

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=77955051716&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955051716&partnerID=8YFLogxK

U2 - 10.1016/j.yfrne.2010.06.002

DO - 10.1016/j.yfrne.2010.06.002

M3 - Article

VL - 31

SP - 377

EP - 393

JO - Frontiers in Neuroendocrinology

JF - Frontiers in Neuroendocrinology

SN - 0091-3022

IS - 3

ER -