Abstract
Leptin regulates energy homeostasis and reproductive, neuroendocrine, immune, and metabolic functions. In this review, we describe the role of leptin in human physiology and review evidence from recent " proof of concept" clinical trials using recombinant human leptin in subjects with congenital leptin deficiency, hypoleptinemia associated with energy-deficient states, and hyperleptinemia associated with garden-variety obesity. Since most obese individuals are largely leptin-tolerant or -resistant, therapeutic uses of leptin are currently limited to patients with complete or partial leptin deficiency, including hypothalamic amenorrhea and lipoatrophy. Leptin administration in these energy-deficient states may help restore associated neuroendocrine, metabolic, and immune function and bone metabolism. Leptin treatment is currently available for individuals with congenital leptin deficiency and congenital lipoatrophy. The long-term efficacy and safety of leptin treatment in hypothalamic amenorrhea and acquired lipoatrophy are currently under investigation. Whether combination therapy with leptin and potential leptin sensitizers will prove effective in the treatment of garden-variety obesity and whether leptin may have a role in weight loss maintenance is being greatly anticipated.
| Original language | English |
|---|---|
| Pages (from-to) | 377-393 |
| Number of pages | 17 |
| Journal | Frontiers in Neuroendocrinology |
| Volume | 31 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2010 Jul 1 |
| Externally published | Yes |
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Keywords
- Adipokines
- Amenorrhea
- Energy homeostasis
- Insulin resistance
- Leptin
- Leptin deficiency
- Leptin resistance
- Lipoatrophy
- Obesity
ASJC Scopus subject areas
- Endocrine and Autonomic Systems
Cite this
Leptin in human physiology and therapeutics. / Dardeno, Tina A.; Chou, Sharon H.; Moon, Hyun-Seuk; Chamberland, John P.; Fiorenza, Christina G.; Mantzoros, Christos S.
In: Frontiers in Neuroendocrinology, Vol. 31, No. 3, 01.07.2010, p. 377-393.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Leptin in human physiology and therapeutics
AU - Dardeno, Tina A.
AU - Chou, Sharon H.
AU - Moon, Hyun-Seuk
AU - Chamberland, John P.
AU - Fiorenza, Christina G.
AU - Mantzoros, Christos S.
PY - 2010/7/1
Y1 - 2010/7/1
N2 - Leptin regulates energy homeostasis and reproductive, neuroendocrine, immune, and metabolic functions. In this review, we describe the role of leptin in human physiology and review evidence from recent " proof of concept" clinical trials using recombinant human leptin in subjects with congenital leptin deficiency, hypoleptinemia associated with energy-deficient states, and hyperleptinemia associated with garden-variety obesity. Since most obese individuals are largely leptin-tolerant or -resistant, therapeutic uses of leptin are currently limited to patients with complete or partial leptin deficiency, including hypothalamic amenorrhea and lipoatrophy. Leptin administration in these energy-deficient states may help restore associated neuroendocrine, metabolic, and immune function and bone metabolism. Leptin treatment is currently available for individuals with congenital leptin deficiency and congenital lipoatrophy. The long-term efficacy and safety of leptin treatment in hypothalamic amenorrhea and acquired lipoatrophy are currently under investigation. Whether combination therapy with leptin and potential leptin sensitizers will prove effective in the treatment of garden-variety obesity and whether leptin may have a role in weight loss maintenance is being greatly anticipated.
AB - Leptin regulates energy homeostasis and reproductive, neuroendocrine, immune, and metabolic functions. In this review, we describe the role of leptin in human physiology and review evidence from recent " proof of concept" clinical trials using recombinant human leptin in subjects with congenital leptin deficiency, hypoleptinemia associated with energy-deficient states, and hyperleptinemia associated with garden-variety obesity. Since most obese individuals are largely leptin-tolerant or -resistant, therapeutic uses of leptin are currently limited to patients with complete or partial leptin deficiency, including hypothalamic amenorrhea and lipoatrophy. Leptin administration in these energy-deficient states may help restore associated neuroendocrine, metabolic, and immune function and bone metabolism. Leptin treatment is currently available for individuals with congenital leptin deficiency and congenital lipoatrophy. The long-term efficacy and safety of leptin treatment in hypothalamic amenorrhea and acquired lipoatrophy are currently under investigation. Whether combination therapy with leptin and potential leptin sensitizers will prove effective in the treatment of garden-variety obesity and whether leptin may have a role in weight loss maintenance is being greatly anticipated.
KW - Adipokines
KW - Amenorrhea
KW - Energy homeostasis
KW - Insulin resistance
KW - Leptin
KW - Leptin deficiency
KW - Leptin resistance
KW - Lipoatrophy
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=77955051716&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955051716&partnerID=8YFLogxK
U2 - 10.1016/j.yfrne.2010.06.002
DO - 10.1016/j.yfrne.2010.06.002
M3 - Article
C2 - 20600241
AN - SCOPUS:77955051716
VL - 31
SP - 377
EP - 393
JO - Frontiers in Neuroendocrinology
JF - Frontiers in Neuroendocrinology
SN - 0091-3022
IS - 3
ER -