Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals

Hyun-Seuk Moon, Maria Dalamaga, Sang Yong Kim, Stergios A. Polyzos, Ole Petter Hamnvik, Faidon Magkos, Jason Paruthi, Christos S. Mantzoros

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

Leptin is an adipocyte-secreted hormone that has been proposed to regulate energy homeostasis as well as metabolic, reproductive,neuroendocrine,andimmunefunctions. Inthecontextofopen-labeluncontrolledstudies, leptin administration has demonstrated insulin-sensitizing effects in patients with congenital lipodystrophy associated with relative leptin deficiency. Leptin administration has also been shown to decrease central fat mass and improve insulin sensitivity and fasting insulin and glucose levels in HIV-infected patients with highly active antiretroviral therapy (HAART)-induced lipodystrophy, insulin resistance, and leptin deficiency. On the contrary, the effects of leptin treatment in leptin-replete or hyperleptinemic obese individuals with glucose intolerance and diabetes mellitus have been minimal or null, presumably due to leptin tolerance or resistance that impairs leptin action. Similarly, experimental evidence suggests a null or a possibly adverse role of leptin treatment in nonlipodystrophic patients with nonalcoholic fatty liver disease. In this review, we present a description of leptin biology and signaling; we summarize leptin's contribution to glucose metabolism in animals and humans in vitro, ex vivo, and in vivo; and we provide insights into the emerging clinical applications and therapeutic uses of leptin in humans with lipodystrophy and/or diabetes.

Original languageEnglish
Pages (from-to)377-412
Number of pages36
JournalEndocrine Reviews
Volume34
Issue number3
DOIs
Publication statusPublished - 2013 Jun 1
Externally publishedYes

Fingerprint

Leptin
Insulin
Lipodystrophy
Insulin Resistance
Glucose
Glucose Intolerance
Highly Active Antiretroviral Therapy
Therapeutic Uses
Adipocytes
Fasting
Diabetes Mellitus
Homeostasis
Fats
HIV
Hormones

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Moon, H-S., Dalamaga, M., Kim, S. Y., Polyzos, S. A., Hamnvik, O. P., Magkos, F., ... Mantzoros, C. S. (2013). Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals. Endocrine Reviews, 34(3), 377-412. https://doi.org/10.1210/er.2012-1053

Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals. / Moon, Hyun-Seuk; Dalamaga, Maria; Kim, Sang Yong; Polyzos, Stergios A.; Hamnvik, Ole Petter; Magkos, Faidon; Paruthi, Jason; Mantzoros, Christos S.

In: Endocrine Reviews, Vol. 34, No. 3, 01.06.2013, p. 377-412.

Research output: Contribution to journalArticle

Moon, H-S, Dalamaga, M, Kim, SY, Polyzos, SA, Hamnvik, OP, Magkos, F, Paruthi, J & Mantzoros, CS 2013, 'Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals', Endocrine Reviews, vol. 34, no. 3, pp. 377-412. https://doi.org/10.1210/er.2012-1053
Moon, Hyun-Seuk ; Dalamaga, Maria ; Kim, Sang Yong ; Polyzos, Stergios A. ; Hamnvik, Ole Petter ; Magkos, Faidon ; Paruthi, Jason ; Mantzoros, Christos S. / Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals. In: Endocrine Reviews. 2013 ; Vol. 34, No. 3. pp. 377-412.
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