Lesion detectability on diffusion-weighted imaging in transient global amnesia

The influence of imaging timing and magnetic field strength

Inseon Ryoo, Jae Hyoung Kim, Sang Yun Kim, Byung Se Choi, Cheolkyu Jung, Sung Il Hwang

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Introduction: Transient global amnesia (TGA) is a benign disease with a sudden-onset, transient memory disturbance. Characteristic punctate high-signal intensity lesions in the hippocampus on diffusion-weighted imaging (DWI) have been reported in variable frequencies. We investigated the influence of the timing of DWI and the magnetic field strength on the lesion detectability in TGA. Methods: Seventy-three patients diagnosed with TGA underwent DWI within 24 h after the symptom onset and again on day 3 at either 1.5 (n=31) or 3 T (n=42). The patients were divided into three subgroups according to the time lapse after the symptom onset to the first DWI (0-6 h, 6-12 h, and 12-24 h). Results: The detection rate of the lesions during the first 24 h rose statistically significantly with increased time lapse after the symptom onset (34% in 0-6 h, 62% in 6-12 h, and 67% in 12-24 h). It increased up to 75% on day 3. The detection rate was higher at 3 T than at 1.5 T in all time points (41% vs. 27% in 0-6 h, 70% vs. 44% in 6-12 h, 80% vs. 57% in 12-24 h, and 86% vs. 61% on day 3), but the statistical significance was achieved only on day 3. Conclusion: Awareness of the different lesion detectability on DWI according to the time lapse after the symptom onset can help in diagnosing the patients with suspected TGA. High field strength is another important factor to increase the lesion detectability on DWI.

Original languageEnglish
Pages (from-to)329-334
Number of pages6
JournalNeuroradiology
Volume54
Issue number4
DOIs
Publication statusPublished - 2012 Apr 1
Externally publishedYes

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Transient Global Amnesia
Magnetic Fields
Hippocampus

Keywords

  • Diffusion-weighted imaging
  • Hippocampus
  • Lesion detectability
  • Transient global amnesia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Lesion detectability on diffusion-weighted imaging in transient global amnesia : The influence of imaging timing and magnetic field strength. / Ryoo, Inseon; Kim, Jae Hyoung; Kim, Sang Yun; Choi, Byung Se; Jung, Cheolkyu; Hwang, Sung Il.

In: Neuroradiology, Vol. 54, No. 4, 01.04.2012, p. 329-334.

Research output: Contribution to journalArticle

Ryoo, Inseon ; Kim, Jae Hyoung ; Kim, Sang Yun ; Choi, Byung Se ; Jung, Cheolkyu ; Hwang, Sung Il. / Lesion detectability on diffusion-weighted imaging in transient global amnesia : The influence of imaging timing and magnetic field strength. In: Neuroradiology. 2012 ; Vol. 54, No. 4. pp. 329-334.
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abstract = "Introduction: Transient global amnesia (TGA) is a benign disease with a sudden-onset, transient memory disturbance. Characteristic punctate high-signal intensity lesions in the hippocampus on diffusion-weighted imaging (DWI) have been reported in variable frequencies. We investigated the influence of the timing of DWI and the magnetic field strength on the lesion detectability in TGA. Methods: Seventy-three patients diagnosed with TGA underwent DWI within 24 h after the symptom onset and again on day 3 at either 1.5 (n=31) or 3 T (n=42). The patients were divided into three subgroups according to the time lapse after the symptom onset to the first DWI (0-6 h, 6-12 h, and 12-24 h). Results: The detection rate of the lesions during the first 24 h rose statistically significantly with increased time lapse after the symptom onset (34{\%} in 0-6 h, 62{\%} in 6-12 h, and 67{\%} in 12-24 h). It increased up to 75{\%} on day 3. The detection rate was higher at 3 T than at 1.5 T in all time points (41{\%} vs. 27{\%} in 0-6 h, 70{\%} vs. 44{\%} in 6-12 h, 80{\%} vs. 57{\%} in 12-24 h, and 86{\%} vs. 61{\%} on day 3), but the statistical significance was achieved only on day 3. Conclusion: Awareness of the different lesion detectability on DWI according to the time lapse after the symptom onset can help in diagnosing the patients with suspected TGA. High field strength is another important factor to increase the lesion detectability on DWI.",
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