Lessons learned from continued TB outbreaks in a high school

Young Kim, Byeong Ki Kim, Hong Jo Choi, Sung Weon Ryu, Eui Sook Kim, Yoon Soo Chang, Hee Jin Kim, Jae Hyung Cha, Je Hyeong Kim, Chol Shin, Seung Heon Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We investigated the aftereffects of confirmatory QuantiFERON testing (QFT) added to a positive tuberculin skin test (TST). We reviewed the pre and post course of sequential tuberculosis (TB) outbreaks in a high school where massive 43 active TB cases had been found within one year before delayed contact investigation. And we investigated the TB development in relation to initial TST and QFT during mean follow-up of 3.9 ± 0.9 years. After delayed contact investigation for two subsequent TB outbreaks, 925 contacts were divided into the following 3 groups: TST- (n = 632), TST+/QFT+ (n = 24), TST+/QFT- (n = 258). QFT- was more prevalent than QFT+ in contacts with 10mm ≤ TST <15mm (158, 61.2%) compared with TST ≥15mm (100, 38.8%) among the TST+ reactors (P < 0.001). Among the 258 TST+/QFT- subjects, 256 received no latent TB infection (LTBI) treatment, but 7 contacts developed TB during follow-up. Among these 7 patients, 4 had initial TST 15mm and 3 had 10mm TST <15mm. In conclusion, the delayed contact investigation for LTBI in a high school resulted in continued TB developments. False-negative QFT performed late among the TST+ reactors should not be considered criteria for LTBI treatment. Additionally, the contacts only with TST ≥15mm should be considered for LTBI treatment in congregate settings of intermediate-burden countries.

Original languageEnglish
Article numbere0188076
JournalPLoS One
Volume12
Issue number11
DOIs
Publication statusPublished - 2017 Nov 1

Fingerprint

Tuberculin Test
high schools
tuberculin
skin tests
Tuberculin
Skin Tests
tuberculosis
Disease Outbreaks
Skin
Tuberculosis
Testing
testing
infection
Infection
Latent Tuberculosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Kim, Y., Kim, B. K., Choi, H. J., Ryu, S. W., Kim, E. S., Chang, Y. S., ... Lee, S. H. (2017). Lessons learned from continued TB outbreaks in a high school. PLoS One, 12(11), [e0188076]. https://doi.org/10.1371/journal.pone.0188076

Lessons learned from continued TB outbreaks in a high school. / Kim, Young; Kim, Byeong Ki; Choi, Hong Jo; Ryu, Sung Weon; Kim, Eui Sook; Chang, Yoon Soo; Kim, Hee Jin; Cha, Jae Hyung; Kim, Je Hyeong; Shin, Chol; Lee, Seung Heon.

In: PLoS One, Vol. 12, No. 11, e0188076, 01.11.2017.

Research output: Contribution to journalArticle

Kim, Y, Kim, BK, Choi, HJ, Ryu, SW, Kim, ES, Chang, YS, Kim, HJ, Cha, JH, Kim, JH, Shin, C & Lee, SH 2017, 'Lessons learned from continued TB outbreaks in a high school', PLoS One, vol. 12, no. 11, e0188076. https://doi.org/10.1371/journal.pone.0188076
Kim Y, Kim BK, Choi HJ, Ryu SW, Kim ES, Chang YS et al. Lessons learned from continued TB outbreaks in a high school. PLoS One. 2017 Nov 1;12(11). e0188076. https://doi.org/10.1371/journal.pone.0188076
Kim, Young ; Kim, Byeong Ki ; Choi, Hong Jo ; Ryu, Sung Weon ; Kim, Eui Sook ; Chang, Yoon Soo ; Kim, Hee Jin ; Cha, Jae Hyung ; Kim, Je Hyeong ; Shin, Chol ; Lee, Seung Heon. / Lessons learned from continued TB outbreaks in a high school. In: PLoS One. 2017 ; Vol. 12, No. 11.
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