TY - JOUR
T1 - Life-long endogenous estrogen exposure is associated with prevalence of allergic rhinitis in postmenopausal women
AU - Lee, Kijeong
AU - Hong, Yeji
AU - Choi, Jimi
AU - Lee, Sang Hag
AU - Kim, Tae Hoon
N1 - Funding Information:
Received November 14, 2018; revised and accepted January 17, 2019. From the 1Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea; and 2Department of Biostatistics, Korea University College of Medicine, Seoul, Korea. Funding/support: This study was supported by the Korea Health Industry Development Institute (KHIDI) by the Ministry of Health and Welfare (HI17C0387). Financial disclosures/conflicts of interest: None reported. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Website (www.menopause.org). Address correspondence to: Tae Hoon Kim, MD, PhD, Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Korea University, 73 Inchon-ro, Seongbuk-gu, Seoul 02841, Korea. E-mail: doctorthk@gmail.com
Publisher Copyright:
© 2019 by The North American Menopause Society.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Objectives: The aim of the study was to investigate the influence of life-long endogenous estrogen exposure on prevalence of chronic rhinitis including allergic rhinitis (AR) in the postmenopausal period. Methods: In this cross-sectional study, a total of 3,043 postmenopausal women who participated in the Korea National Health and Nutrition Examination Survey V were included. Participants with symptoms including sneezing, rhinorrhea, nasal obstruction, or nasal itching were considered to have chronic rhinitis. In subgroup analysis, the AR group comprised participants with rhinitis with positive findings in at least one of three specific immunoglobulin E. Univariable and multivariable logistic analyses were performed to evaluate the relationship between rhinitis and estrogen-related factors including age at menarche, age at menopause, age at first delivery, parity, and duration of breast-feeding. Results: Participants with chronic rhinitis (17.6%) had higher parity (odd ratio [OR] = 1.17, P = 0.0135) and shorter duration of breast-feeding (OR = 0.98, P = 0.0388) than controls. In subgroup analysis, participants with AR (7.1%) had younger age at menarche (OR = 0.56, P = 0.0028) and older age at menopause (OR = 1.42, P = 0.0060) after adjustment of confounding factors. There was a positive association between age at menopause and specific immunoglobulin E for both cockroach (OR = 1.38, P = 0.0132) and dogs (OR = 1.38, P = 0.0302). Longer postmenopausal duration was positively associated with cockroach allergen sensitization (OR = 1.25, P = 0.201). Conclusions: Longer duration of reproductive period was associated with higher prevalence of AR and aeroallergen sensitization in the postmenopausal period. Moreover, cockroach allergen sensitization was associated with a longer postmenopausal period.
AB - Objectives: The aim of the study was to investigate the influence of life-long endogenous estrogen exposure on prevalence of chronic rhinitis including allergic rhinitis (AR) in the postmenopausal period. Methods: In this cross-sectional study, a total of 3,043 postmenopausal women who participated in the Korea National Health and Nutrition Examination Survey V were included. Participants with symptoms including sneezing, rhinorrhea, nasal obstruction, or nasal itching were considered to have chronic rhinitis. In subgroup analysis, the AR group comprised participants with rhinitis with positive findings in at least one of three specific immunoglobulin E. Univariable and multivariable logistic analyses were performed to evaluate the relationship between rhinitis and estrogen-related factors including age at menarche, age at menopause, age at first delivery, parity, and duration of breast-feeding. Results: Participants with chronic rhinitis (17.6%) had higher parity (odd ratio [OR] = 1.17, P = 0.0135) and shorter duration of breast-feeding (OR = 0.98, P = 0.0388) than controls. In subgroup analysis, participants with AR (7.1%) had younger age at menarche (OR = 0.56, P = 0.0028) and older age at menopause (OR = 1.42, P = 0.0060) after adjustment of confounding factors. There was a positive association between age at menopause and specific immunoglobulin E for both cockroach (OR = 1.38, P = 0.0132) and dogs (OR = 1.38, P = 0.0302). Longer postmenopausal duration was positively associated with cockroach allergen sensitization (OR = 1.25, P = 0.201). Conclusions: Longer duration of reproductive period was associated with higher prevalence of AR and aeroallergen sensitization in the postmenopausal period. Moreover, cockroach allergen sensitization was associated with a longer postmenopausal period.
KW - Allergic rhinitis
KW - Cockroach allergen
KW - Estrogen
KW - Menopause
KW - Rhinitis
UR - http://www.scopus.com/inward/record.url?scp=85070789951&partnerID=8YFLogxK
U2 - 10.1097/GME.0000000000001319
DO - 10.1097/GME.0000000000001319
M3 - Article
C2 - 30889092
AN - SCOPUS:85070789951
VL - 26
SP - 885
EP - 891
JO - Menopause
JF - Menopause
SN - 1072-3714
IS - 8
ER -