Lifestyle modification increases circulating adiponectin concentrations but does not change vaspin concentrations

Seon Mee Kim, Geum-Joon Cho, Mary Yannakoulia, Taik Gun Hwang, In Hee Kim, Eun Kyung Park, Christos S. Mantzoros

Research output: Contribution to journalArticle

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Abstract

The objective of the study was to evaluate the effects of a 10-month lifestyle intervention on the components of the metabolic syndrome (MetSyn) in Koreans with MetSyn as well as on blood concentrations of adiponectin and vaspin. One hundred thirty-eight patients with MetSyn, recruited from a community health care center, were consecutively enrolled in the study; 12 patients dropped of the intervention, leaving 126 subjects (76 men and 50 women; age, 65.3 ± 9.0 years). All participants followed a 10-month lifestyle modification interventional program, including dietary counseling, advice on increasing physical activity, and recommendations to stop or limit smoking and alcohol drinking. Anthropometric and biochemical parameters related to the components of the MetSyn, including blood concentrations of adiponectin and vaspin, were assessed pre- and postintervention. At baseline, adiponectin concentrations were moderately negatively correlated to insulin concentrations and insulin resistance evaluated by the homeostasis model assessment. In response to lifestyle modification, statistically significant changes were found in systolic and diastolic blood pressure, total cholesterol, triglyceride, and insulin concentrations, as well as in homeostasis model assessment of insulin resistance. Adiponectin concentrations postintervention, compared with the preintervention levels, increased (7.2 ± 4.0 vs 6.8 ± 3.9 μg/mL, respectively; P <.05), whereas vaspin concentrations remained unchanged (0.25 ± 0.19 vs 0.26 ± 0.20 ng/mL, respectively; P =.64). A 10-month lifestyle modification program in Korean patients with MetSyn led to favorable changes in metabolic parameters and adiponectin but not vaspin concentrations.

Original languageEnglish
Pages (from-to)1294-1299
Number of pages6
JournalMetabolism: Clinical and Experimental
Volume60
Issue number9
DOIs
Publication statusPublished - 2011 Sep 1

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Adiponectin
Life Style
Insulin Resistance
Homeostasis
Insulin
Blood Pressure
Community Health Centers
Community Health Services
Alcohol Drinking
Counseling
Triglycerides
Smoking
Cholesterol
Exercise

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Lifestyle modification increases circulating adiponectin concentrations but does not change vaspin concentrations. / Kim, Seon Mee; Cho, Geum-Joon; Yannakoulia, Mary; Hwang, Taik Gun; Kim, In Hee; Park, Eun Kyung; Mantzoros, Christos S.

In: Metabolism: Clinical and Experimental, Vol. 60, No. 9, 01.09.2011, p. 1294-1299.

Research output: Contribution to journalArticle

Kim, Seon Mee ; Cho, Geum-Joon ; Yannakoulia, Mary ; Hwang, Taik Gun ; Kim, In Hee ; Park, Eun Kyung ; Mantzoros, Christos S. / Lifestyle modification increases circulating adiponectin concentrations but does not change vaspin concentrations. In: Metabolism: Clinical and Experimental. 2011 ; Vol. 60, No. 9. pp. 1294-1299.
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