Lignans from Arctium lappa and their inhibition of LPS-induced nitric oxide production

So Young Park, Seong Su Hong, Xiang Hua Han, Ji Sang Hwang, Dongho Lee, Jai Seup Ro, Bang Yeon Hwang

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

A new butyrolactone sesquilignan, isolappaol C (1), together with four known lignans, lappaol C (2), lappaol D (3), lappaol F (4), and diarctigenin (5), were isolated from the methanolic extract of the seeds from the Arctium lappa plant. The structure of isolappaol C (1) was determined by spectral analysis including 1D- and 2D-NMR. All the isolates were evaluated for their inhibitory effects on the LPS-induced nitric oxide production using murine macrophage RAW264.7 cells. Lappaol F (4) and diarctigenin (5) strongly inhibited NO production in the LPS-stimulated RAW264.7 cells with IC50 values of 9.5 and 9.6 μM, respectively.

Original languageEnglish
Pages (from-to)150-152
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume55
Issue number1
DOIs
Publication statusPublished - 2007 Jan

Keywords

  • Arctium lappa
  • Compositae
  • Isolappaol C
  • Lignan
  • Nitric oxide production inhibitor

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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