Lignans from Saururus chinensis with Inhibitory Effects on Nitric Oxide Production

Qinghao Jin, Jin Woo Lee, Jun Gu Kim, Dongho Lee, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Three biogenetically related ent-sauchinone-type lignans (1-3), four 8-O-4′-type neolignans (4-7), a diaryldimethylbutane lignan (8), and a cyclic carbonate (9), along with 12 known compounds, have been isolated from a methanol extract of the aerial parts of Saururus chinensis. The structures of the new compounds (1-9) were determined by analysis of their 1D and 2D NMR spectra, HRESIMS, and ECD data. A putative biosynthetic pathway for the three ent-sauchinone-type lignans (1-3) was postulated. Compounds 1, 7, and 10 showed inhibitory effects on LPS-induced NO production in RAW 264.7 cells with IC50 values of 5.6, 8.6, and 9.2 μM, respectively.

Original languageEnglish
Pages (from-to)3002-3009
Number of pages8
JournalJournal of Natural Products
Volume82
Issue number11
DOIs
Publication statusPublished - 2019 Nov 22

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Jin, Q., Lee, J. W., Kim, J. G., Lee, D., Hong, J. T., Kim, Y., Lee, M. K., & Hwang, B. Y. (2019). Lignans from Saururus chinensis with Inhibitory Effects on Nitric Oxide Production. Journal of Natural Products, 82(11), 3002-3009. https://doi.org/10.1021/acs.jnatprod.9b00520