Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanisms

Sung Yun Cho, Hee Jin Jun, Ji Hae Lee, Yaoyao Jia, Kyoung Heon Kim, Sung Joon Lee

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

We investigated hypocholesterolemic mechanisms of linalool, an aromatic anti-oxidative monoterpene, which is abundant in teas and essential oils. Oral administration of linalool to mice for 6 weeks significantly lowered total and low-density lipoprotein cholesterol concentrations, and HMG-CoA reductase protein expression (-46%; P < 0.05) by both transcriptional and posttranscriptional mechanisms. Linalool suppressed the gene expression of HMG-CoA reductase by reducing the binding of SREBP-2 to its promoter, as assessed by qPCR and chromatin immunoprecipitation, and by inducing ubiquitin-dependent proteolysis of the HMG-CoA reductase. These findings suggest that food molecules with a pleasant scent could exert beneficial metabolic effects through multiple mechanisms.

Original languageEnglish
Pages (from-to)3289-3296
Number of pages8
JournalFEBS Letters
Volume585
Issue number20
DOIs
Publication statusPublished - 2011 Oct 20

Keywords

  • Cholesterol
  • HMG-CoA reductase
  • Sterol regulatory element binding protein-2
  • Ubiquitination

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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