Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanisms

Sung Yun Cho, Hee Jin Jun, Ji Hae Lee, Yaoyao Jia, Kyoung Heon Kim, Sung-Joon Lee

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

We investigated hypocholesterolemic mechanisms of linalool, an aromatic anti-oxidative monoterpene, which is abundant in teas and essential oils. Oral administration of linalool to mice for 6 weeks significantly lowered total and low-density lipoprotein cholesterol concentrations, and HMG-CoA reductase protein expression (-46%; P < 0.05) by both transcriptional and posttranscriptional mechanisms. Linalool suppressed the gene expression of HMG-CoA reductase by reducing the binding of SREBP-2 to its promoter, as assessed by qPCR and chromatin immunoprecipitation, and by inducing ubiquitin-dependent proteolysis of the HMG-CoA reductase. These findings suggest that food molecules with a pleasant scent could exert beneficial metabolic effects through multiple mechanisms.

Original languageEnglish
Pages (from-to)3289-3296
Number of pages8
JournalFEBS Letters
Volume585
Issue number20
DOIs
Publication statusPublished - 2011 Oct 20

Fingerprint

Sterol Regulatory Element Binding Protein 2
Hydroxymethylglutaryl CoA Reductases
Ubiquitin
Proteolysis
Monoterpenes
Chromatin Immunoprecipitation
Tea
Volatile Oils
Gene expression
LDL Cholesterol
Chromatin
Oral Administration
Gene Expression
Food
Molecules
linalool
Proteins

Keywords

  • Cholesterol
  • HMG-CoA reductase
  • Sterol regulatory element binding protein-2
  • Ubiquitination

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

Cite this

Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanisms. / Cho, Sung Yun; Jun, Hee Jin; Lee, Ji Hae; Jia, Yaoyao; Kim, Kyoung Heon; Lee, Sung-Joon.

In: FEBS Letters, Vol. 585, No. 20, 20.10.2011, p. 3289-3296.

Research output: Contribution to journalArticle

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