Linalyl acetate prevents three related factors of vascular damage in COPD-like and hypertensive rats

Yu Shan Hsieh, You Kyoung Shin, A. Young Han, Soonho Kwon, Geun Hee Seol

Research output: Contribution to journalArticle

Abstract

Preventing vascular damage is considered an effective strategy in patients who suffer from chronic obstructive pulmonary disease (COPD) with hypertension. Here, we investigated vascular damage in COPD-like and hypertensive rats, which demonstrated the presence of the three related factors of COPD with hypertension. These include elevated systolic blood pressure (SBP), serum malondialdehyde (MDA) and serum lactate dehydrogenase (LDH), which are positively correlated with vascular damage in patients. In addition to increases in these three related factors, COPD-like and hypertensive rats exhibited increased levels of pro-inflammatory mediators, such as tumor necrosis factor-α, interleukin-6, and matrix metallopeptidase-9 in bronchoalveolar lavage fluid, and enlargement of alveolar airspaces, recapitulating clinical findings in previous studies of patients. Moreover, the appearance of these related factors was prevented by linalyl acetate. Our results provide novel insight into the potential of LA to prevent vascular damage and elevated SBP, serum MDA and serum LDH in COPD with hypertension, and could lead to an alternative strategy for preventing vascular damage for patients who suffered from COPD with hypertension in a clinical setting.

Original languageEnglish
Article number116608
JournalLife Sciences
Volume232
DOIs
Publication statusPublished - 2019 Sep 1

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Pulmonary diseases
Chronic Obstructive Pulmonary Disease
Rats
Blood Vessels
Blood Pressure
Hypertension
Blood pressure
Malondialdehyde
Serum
L-Lactate Dehydrogenase
Bronchoalveolar Lavage Fluid
Metalloproteases
linalyl acetate
vascular factor
Interleukin-6
Tumor Necrosis Factor-alpha
Fluids

Keywords

  • Comorbidity
  • COPD
  • Hypertension
  • Linalyl acetate
  • Vascular damage

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Linalyl acetate prevents three related factors of vascular damage in COPD-like and hypertensive rats. / Hsieh, Yu Shan; Shin, You Kyoung; Han, A. Young; Kwon, Soonho; Seol, Geun Hee.

In: Life Sciences, Vol. 232, 116608, 01.09.2019.

Research output: Contribution to journalArticle

Hsieh, Yu Shan ; Shin, You Kyoung ; Han, A. Young ; Kwon, Soonho ; Seol, Geun Hee. / Linalyl acetate prevents three related factors of vascular damage in COPD-like and hypertensive rats. In: Life Sciences. 2019 ; Vol. 232.
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