Lipopolysaccharide induces pro-inflammatory cytokines and mmp production via TLR4 in nasal polyp-derived fibroblast and organ culture

Agriculture & Biology

• organ culture 88%
• lipopolysaccharides 72%
• cytokines 71%
• fibroblasts 66%
• interstitial collagenase 38%
• interleukin-8 23%
• metalloproteinases 21%
• interleukin-6 20%
• Toll-like receptors 16%
• phosphatidylinositol 3-kinase 16%
• phosphotransferases (kinases) 16%
• protein synthesis 14%
• Toll-like receptor 4 9%
• gelatinase B 9%
• gelatinase A 9%
• Rhodobacter sphaeroides 8%
• collagenase 7%
• mitogen-activated protein kinase 6%
• innate immunity 6%
• gelatin 6%
• mucosa 6%
• fluorescent antibody technique 5%
• agonists 5%
• inflammation 5%
• tissues 5%
• collagen 5%
• Western blotting 5%
• immune response 5%
• enzyme-linked immunosorbent assay 5%
• reverse transcriptase polymerase chain reaction 4%
• proteinases 4%
• staining 4%
• microorganisms 4%
• gene expression 3%

Medicine & Life Sciences

• Nasal Polyps 98%
• Organ Culture Techniques 89%
• Fibroblasts 56%
• Cytokines 46%
• Matrix Metalloproteinase 1 33%
• Matrix Metalloproteinases 19%
• Interleukin-8 19%
• Phosphotransferases 15%
• Interleukin-6 15%
• Toll-Like Receptors 14%
• Phosphatidylinositol 3-Kinases 13%
• Rhodobacter sphaeroides 10%
• Gelatinases 9%
• Turbinates 8%
• Toll-Like Receptor 4 7%
• Messenger RNA 7%
• JNK Mitogen-Activated Protein Kinases 7%
• Proteins 7%
• Matrix Metalloproteinase 2 7%
• Collagenases 7%
• Gelatin 7%
• Matrix Metalloproteinase 9 7%
• Innate Immunity 6%
• Fluorescent Antibody Technique 5%
• Nose 5%
• Mucous Membrane 5%
• Real-Time Polymerase Chain Reaction 5%
• Collagen 5%
• Enzyme-Linked Immunosorbent Assay 4%
• Western Blotting 4%
• Staining and Labeling 4%
• Gene Expression 4%
• Inflammation 4%

Chemical Compounds

• Nasal 100%
• Lipopolysaccharide 83%
• Protein 7%
• Microarrays 6%
• Gelatin 6%
• Agonist 6%
• Collagen 5%
• Enzyme Activity 5%