Lipopolysaccharides-activated human astroglioma cells induce apoptotic death of T-lymphocytes via c-Jun N-terminal kinases-dependent up-regulation of TRAIL

Daeho Kwon; Jae Hoon Cheong; Jae Chul Lee; Jae Hyun Kwon; Won Ki Kim

doi:10.1016/j.neures.2005.12.011

Lipopolysaccharides-activated human astroglioma cells induce apoptotic death of T-lymphocytes via c-Jun N-terminal kinases-dependent up-regulation of TRAIL

Daeho Kwon, Jae Hoon Cheong, Jae Chul Lee, Jae Hyun Kwon, Won Ki Kim

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

In the present study, we report that activated human astroglioma cells can injure T-lymphocytes by producing tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). Treatment with lipopolysaccharides (LPS), a well-known immune stimulator, increased the expression levels of TRAIL mRNA and protein in human astroglioma cells. The increase of TRAIL mRNA expression by LPS was preceded by phosphorylation of the c-Jun N-terminal kinase (JNK) and consequently abrogated in the presence of the specific JNK inhibitor SP600125. The up-regulation of TRAIL expression was well co-related with AP-1 activation. Activated human astroglioma cells markedly induced the apoptotic death of T-lymphocytes. Pre-treatment with the TRAIL antagonistic protein TRAIL-R2:Fc prevented the death of T-lymphocytes caused by activated human astroglioma cells. The present results suggest that astroglioma cells may down-regulate T-lymphocytes via up-regulation of TRAIL.

Original language	English
Pages (from-to)	338-343
Number of pages	6
Journal	Neuroscience Research
Volume	54
Issue number	4
DOIs	https://doi.org/10.1016/j.neures.2005.12.011
Publication status	Published - 2006 Apr
Externally published	Yes

Keywords

Astroglioma
Cell death
T-lymphocytes
TRAIL
c-Jun N-terminal kinase

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/j.neures.2005.12.011

Fingerprint Dive into the research topics of 'Lipopolysaccharides-activated human astroglioma cells induce apoptotic death of T-lymphocytes via c-Jun N-terminal kinases-dependent up-regulation of TRAIL'. Together they form a unique fingerprint.

Cite this

@article{5af4557c18e0447493459c2b15766bd7,

title = "Lipopolysaccharides-activated human astroglioma cells induce apoptotic death of T-lymphocytes via c-Jun N-terminal kinases-dependent up-regulation of TRAIL",

abstract = "In the present study, we report that activated human astroglioma cells can injure T-lymphocytes by producing tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). Treatment with lipopolysaccharides (LPS), a well-known immune stimulator, increased the expression levels of TRAIL mRNA and protein in human astroglioma cells. The increase of TRAIL mRNA expression by LPS was preceded by phosphorylation of the c-Jun N-terminal kinase (JNK) and consequently abrogated in the presence of the specific JNK inhibitor SP600125. The up-regulation of TRAIL expression was well co-related with AP-1 activation. Activated human astroglioma cells markedly induced the apoptotic death of T-lymphocytes. Pre-treatment with the TRAIL antagonistic protein TRAIL-R2:Fc prevented the death of T-lymphocytes caused by activated human astroglioma cells. The present results suggest that astroglioma cells may down-regulate T-lymphocytes via up-regulation of TRAIL.",

keywords = "Astroglioma, Cell death, T-lymphocytes, TRAIL, c-Jun N-terminal kinase",

author = "Daeho Kwon and Cheong, {Jae Hoon} and Lee, {Jae Chul} and Kwon, {Jae Hyun} and Kim, {Won Ki}",

note = "Funding Information: This work was supported by a grant (M103KV010005 03K2201 00510) from Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology, Republic of Korea. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2006",

month = apr,

doi = "10.1016/j.neures.2005.12.011",

language = "English",

volume = "54",

pages = "338--343",

journal = "Neuroscience Research",

issn = "0168-0102",

publisher = "Elsevier Ireland Ltd",

number = "4",

}

TY - JOUR

T1 - Lipopolysaccharides-activated human astroglioma cells induce apoptotic death of T-lymphocytes via c-Jun N-terminal kinases-dependent up-regulation of TRAIL

AU - Kwon, Daeho

AU - Cheong, Jae Hoon

AU - Lee, Jae Chul

AU - Kwon, Jae Hyun

AU - Kim, Won Ki

N1 - Funding Information: This work was supported by a grant (M103KV010005 03K2201 00510) from Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology, Republic of Korea. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2006/4

Y1 - 2006/4

N2 - In the present study, we report that activated human astroglioma cells can injure T-lymphocytes by producing tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). Treatment with lipopolysaccharides (LPS), a well-known immune stimulator, increased the expression levels of TRAIL mRNA and protein in human astroglioma cells. The increase of TRAIL mRNA expression by LPS was preceded by phosphorylation of the c-Jun N-terminal kinase (JNK) and consequently abrogated in the presence of the specific JNK inhibitor SP600125. The up-regulation of TRAIL expression was well co-related with AP-1 activation. Activated human astroglioma cells markedly induced the apoptotic death of T-lymphocytes. Pre-treatment with the TRAIL antagonistic protein TRAIL-R2:Fc prevented the death of T-lymphocytes caused by activated human astroglioma cells. The present results suggest that astroglioma cells may down-regulate T-lymphocytes via up-regulation of TRAIL.

AB - In the present study, we report that activated human astroglioma cells can injure T-lymphocytes by producing tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). Treatment with lipopolysaccharides (LPS), a well-known immune stimulator, increased the expression levels of TRAIL mRNA and protein in human astroglioma cells. The increase of TRAIL mRNA expression by LPS was preceded by phosphorylation of the c-Jun N-terminal kinase (JNK) and consequently abrogated in the presence of the specific JNK inhibitor SP600125. The up-regulation of TRAIL expression was well co-related with AP-1 activation. Activated human astroglioma cells markedly induced the apoptotic death of T-lymphocytes. Pre-treatment with the TRAIL antagonistic protein TRAIL-R2:Fc prevented the death of T-lymphocytes caused by activated human astroglioma cells. The present results suggest that astroglioma cells may down-regulate T-lymphocytes via up-regulation of TRAIL.

KW - Astroglioma

KW - Cell death

KW - T-lymphocytes

KW - TRAIL

KW - c-Jun N-terminal kinase

UR - http://www.scopus.com/inward/record.url?scp=33644852678&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644852678&partnerID=8YFLogxK

U2 - 10.1016/j.neures.2005.12.011

DO - 10.1016/j.neures.2005.12.011

M3 - Article

C2 - 16442178

AN - SCOPUS:33644852678

VL - 54

SP - 338

EP - 343

JO - Neuroscience Research

JF - Neuroscience Research

SN - 0168-0102

IS - 4

ER -

Lipopolysaccharides-activated human astroglioma cells induce apoptotic death of T-lymphocytes via c-Jun N-terminal kinases-dependent up-regulation of TRAIL

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this