Abstract
In the present study, we report that activated human astroglioma cells can injure T-lymphocytes by producing tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). Treatment with lipopolysaccharides (LPS), a well-known immune stimulator, increased the expression levels of TRAIL mRNA and protein in human astroglioma cells. The increase of TRAIL mRNA expression by LPS was preceded by phosphorylation of the c-Jun N-terminal kinase (JNK) and consequently abrogated in the presence of the specific JNK inhibitor SP600125. The up-regulation of TRAIL expression was well co-related with AP-1 activation. Activated human astroglioma cells markedly induced the apoptotic death of T-lymphocytes. Pre-treatment with the TRAIL antagonistic protein TRAIL-R2:Fc prevented the death of T-lymphocytes caused by activated human astroglioma cells. The present results suggest that astroglioma cells may down-regulate T-lymphocytes via up-regulation of TRAIL.
Original language | English |
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Pages (from-to) | 338-343 |
Number of pages | 6 |
Journal | Neuroscience Research |
Volume | 54 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2006 Apr |
Externally published | Yes |
Keywords
- Astroglioma
- Cell death
- T-lymphocytes
- TRAIL
- c-Jun N-terminal kinase
ASJC Scopus subject areas
- Neuroscience(all)