Lipopolysaccharides-activated human astroglioma cells induce apoptotic death of T-lymphocytes via c-Jun N-terminal kinases-dependent up-regulation of TRAIL

Daeho Kwon, Jae Hoon Cheong, Jae Chul Lee, Jae Hyun Kwon, Won Ki Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In the present study, we report that activated human astroglioma cells can injure T-lymphocytes by producing tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). Treatment with lipopolysaccharides (LPS), a well-known immune stimulator, increased the expression levels of TRAIL mRNA and protein in human astroglioma cells. The increase of TRAIL mRNA expression by LPS was preceded by phosphorylation of the c-Jun N-terminal kinase (JNK) and consequently abrogated in the presence of the specific JNK inhibitor SP600125. The up-regulation of TRAIL expression was well co-related with AP-1 activation. Activated human astroglioma cells markedly induced the apoptotic death of T-lymphocytes. Pre-treatment with the TRAIL antagonistic protein TRAIL-R2:Fc prevented the death of T-lymphocytes caused by activated human astroglioma cells. The present results suggest that astroglioma cells may down-regulate T-lymphocytes via up-regulation of TRAIL.

Original languageEnglish
Pages (from-to)338-343
Number of pages6
JournalNeuroscience Research
Volume54
Issue number4
DOIs
Publication statusPublished - 2006 Apr
Externally publishedYes

Keywords

  • Astroglioma
  • Cell death
  • T-lymphocytes
  • TRAIL
  • c-Jun N-terminal kinase

ASJC Scopus subject areas

  • Neuroscience(all)

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