Abstract
A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method as an alternative to a gas chromatography-thermal energy analyser (GC-TEA) method recommended by the European Committee on Standardization (CEN) was validated for the simultaneous determination of eight N-nitrosamines released into artificial saliva from rubber or elastomer teats and soothers. N-nitroso-dipropylamine-d14 (NDPA-d14) was used as internal standard for accurate quantification. The method was validated with relatively good analytical results, including sufficiently low limits of detection (0.1-2 μgkg-1 of sample) and good linearity (r2 > 0.99) throughout the studied concentration ranges. Intra- and inter-day precisions expressed with the relative standard deviation (RSD, %) were 3.4-8.0% and 4.4-11.3%, which were below the performance criteria based on one-half of the value derived from the Horwitz value. It was also found that the LC-MS/MS method is sufficiently rugged and successfully applicable to its routine analysis for the compliance test of Commission Directive 93/11/EEC.
Original language | English |
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Pages (from-to) | 1745-1754 |
Number of pages | 10 |
Journal | Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment |
Volume | 27 |
Issue number | 12 |
DOIs | |
Publication status | Published - 2010 Dec |
Keywords
- Liquid chromatography/mass spectrometry (LC/MS)
- Nitrosamines baby food
- Packaging
- Packing migration
ASJC Scopus subject areas
- Food Science
- Chemistry (miscellaneous)
- Chemistry(all)
- Toxicology
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis