Abstract
A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method as an alternative to a gas chromatography-thermal energy analyser (GC-TEA) method recommended by the European Committee on Standardization (CEN) was validated for the simultaneous determination of eight N-nitrosamines released into artificial saliva from rubber or elastomer teats and soothers. N-nitroso-dipropylamine-d14 (NDPA-d14) was used as internal standard for accurate quantification. The method was validated with relatively good analytical results, including sufficiently low limits of detection (0.1-2 μgkg-1 of sample) and good linearity (r2 > 0.99) throughout the studied concentration ranges. Intra- and inter-day precisions expressed with the relative standard deviation (RSD, %) were 3.4-8.0% and 4.4-11.3%, which were below the performance criteria based on one-half of the value derived from the Horwitz value. It was also found that the LC-MS/MS method is sufficiently rugged and successfully applicable to its routine analysis for the compliance test of Commission Directive 93/11/EEC.
| Original language | English |
|---|---|
| Pages (from-to) | 1745-1754 |
| Number of pages | 10 |
| Journal | Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment |
| Volume | 27 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2010 Dec 1 |
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Keywords
- Liquid chromatography/mass spectrometry (LC/MS)
- Nitrosamines baby food
- Packaging
- Packing migration
ASJC Scopus subject areas
- Food Science
- Health, Toxicology and Mutagenesis
- Public Health, Environmental and Occupational Health
- Toxicology
- Chemistry(all)
Cite this
Liquid chromatography-tandem mass spectrometry determination of N-nitrosamines released from rubber or elastomer teats and soothers. / Sung, J. H.; Kwak, I. S.; Park, S. K.; Kim, H. I.; Lim, H. S.; Park, Hyun Jin; Kim, S. H.
In: Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, Vol. 27, No. 12, 01.12.2010, p. 1745-1754.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Liquid chromatography-tandem mass spectrometry determination of N-nitrosamines released from rubber or elastomer teats and soothers
AU - Sung, J. H.
AU - Kwak, I. S.
AU - Park, S. K.
AU - Kim, H. I.
AU - Lim, H. S.
AU - Park, Hyun Jin
AU - Kim, S. H.
PY - 2010/12/1
Y1 - 2010/12/1
N2 - A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method as an alternative to a gas chromatography-thermal energy analyser (GC-TEA) method recommended by the European Committee on Standardization (CEN) was validated for the simultaneous determination of eight N-nitrosamines released into artificial saliva from rubber or elastomer teats and soothers. N-nitroso-dipropylamine-d14 (NDPA-d14) was used as internal standard for accurate quantification. The method was validated with relatively good analytical results, including sufficiently low limits of detection (0.1-2 μgkg-1 of sample) and good linearity (r2 > 0.99) throughout the studied concentration ranges. Intra- and inter-day precisions expressed with the relative standard deviation (RSD, %) were 3.4-8.0% and 4.4-11.3%, which were below the performance criteria based on one-half of the value derived from the Horwitz value. It was also found that the LC-MS/MS method is sufficiently rugged and successfully applicable to its routine analysis for the compliance test of Commission Directive 93/11/EEC.
AB - A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method as an alternative to a gas chromatography-thermal energy analyser (GC-TEA) method recommended by the European Committee on Standardization (CEN) was validated for the simultaneous determination of eight N-nitrosamines released into artificial saliva from rubber or elastomer teats and soothers. N-nitroso-dipropylamine-d14 (NDPA-d14) was used as internal standard for accurate quantification. The method was validated with relatively good analytical results, including sufficiently low limits of detection (0.1-2 μgkg-1 of sample) and good linearity (r2 > 0.99) throughout the studied concentration ranges. Intra- and inter-day precisions expressed with the relative standard deviation (RSD, %) were 3.4-8.0% and 4.4-11.3%, which were below the performance criteria based on one-half of the value derived from the Horwitz value. It was also found that the LC-MS/MS method is sufficiently rugged and successfully applicable to its routine analysis for the compliance test of Commission Directive 93/11/EEC.
KW - Liquid chromatography/mass spectrometry (LC/MS)
KW - Nitrosamines baby food
KW - Packaging
KW - Packing migration
UR - http://www.scopus.com/inward/record.url?scp=78649587519&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78649587519&partnerID=8YFLogxK
U2 - 10.1080/19440049.2010.508184
DO - 10.1080/19440049.2010.508184
M3 - Article
C2 - 21108095
AN - SCOPUS:78649587519
VL - 27
SP - 1745
EP - 1754
JO - Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment
JF - Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment
SN - 0265-203X
IS - 12
ER -