Liquid chromatography-tandem mass spectrometry determination of N-nitrosamines released from rubber or elastomer teats and soothers

J. H. Sung; I. S. Kwak; S. K. Park; H. I. Kim; H. S. Lim; H. J. Park; S. H. Kim

doi:10.1080/19440049.2010.508184

Liquid chromatography-tandem mass spectrometry determination of N-nitrosamines released from rubber or elastomer teats and soothers

J. H. Sung, I. S. Kwak, S. K. Park, H. I. Kim, H. S. Lim, H. J. Park, S. H. Kim

Department of Biotechnology

Research output: Contribution to journal › Article

8 Citations (Scopus)

Abstract

A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method as an alternative to a gas chromatography-thermal energy analyser (GC-TEA) method recommended by the European Committee on Standardization (CEN) was validated for the simultaneous determination of eight N-nitrosamines released into artificial saliva from rubber or elastomer teats and soothers. N-nitroso-dipropylamine-d₁₄ (NDPA-d₁₄) was used as internal standard for accurate quantification. The method was validated with relatively good analytical results, including sufficiently low limits of detection (0.1-2 μgkg^-1 of sample) and good linearity (r² > 0.99) throughout the studied concentration ranges. Intra- and inter-day precisions expressed with the relative standard deviation (RSD, %) were 3.4-8.0% and 4.4-11.3%, which were below the performance criteria based on one-half of the value derived from the Horwitz value. It was also found that the LC-MS/MS method is sufficiently rugged and successfully applicable to its routine analysis for the compliance test of Commission Directive 93/11/EEC.

Original language	English
Pages (from-to)	1745-1754
Number of pages	10
Journal	Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment
Volume	27
Issue number	12
DOIs	https://doi.org/10.1080/19440049.2010.508184
Publication status	Published - 2010 Dec 1

Keywords

Liquid chromatography/mass spectrometry (LC/MS)
Nitrosamines baby food
Packaging
Packing migration

ASJC Scopus subject areas

Food Science
Chemistry(all)
Toxicology
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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Sung, J. H., Kwak, I. S., Park, S. K., Kim, H. I., Lim, H. S., Park, H. J., & Kim, S. H. (2010). Liquid chromatography-tandem mass spectrometry determination of N-nitrosamines released from rubber or elastomer teats and soothers. Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, 27(12), 1745-1754. https://doi.org/10.1080/19440049.2010.508184

Liquid chromatography-tandem mass spectrometry determination of N-nitrosamines released from rubber or elastomer teats and soothers. / Sung, J. H.; Kwak, I. S.; Park, S. K.; Kim, H. I.; Lim, H. S.; Park, H. J.; Kim, S. H.

In: Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, Vol. 27, No. 12, 01.12.2010, p. 1745-1754.

Research output: Contribution to journal › Article

Sung, JH, Kwak, IS, Park, SK, Kim, HI, Lim, HS, Park, HJ & Kim, SH 2010, 'Liquid chromatography-tandem mass spectrometry determination of N-nitrosamines released from rubber or elastomer teats and soothers', Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, vol. 27, no. 12, pp. 1745-1754. https://doi.org/10.1080/19440049.2010.508184

Sung, J. H. ; Kwak, I. S. ; Park, S. K. ; Kim, H. I. ; Lim, H. S. ; Park, H. J. ; Kim, S. H. / Liquid chromatography-tandem mass spectrometry determination of N-nitrosamines released from rubber or elastomer teats and soothers. In: Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment. 2010 ; Vol. 27, No. 12. pp. 1745-1754.

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