Live-cell imaging and profiling of c-Jun N-terminal kinases using covalent inhibitor-derived probes

Linghui Qian, Sijun Pan, Jun Seok Lee, Jingyan Ge, Lin Li, Shao Q. Yao

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

c-Jun N-terminal kinases (JNKs) are involved in critical cellular functions. Herein, small-molecule JNK-targeting probes are reported based on a covalent inhibitor. Together with newly developed two-photon fluorescence Turn-ON reporters and chemoproteomic studies, we showed that some probes may be suitable for live-cell imaging and profiling of JNKs.

Original languageEnglish
Pages (from-to)1092-1095
Number of pages4
JournalChemical Communications
Volume55
Issue number8
DOIs
Publication statusPublished - 2019
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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