Liver cirrhosis induced by porphyria cutanea tarda: A case report and review

Kwang Gyun Lee, Jong Jin Hyun, Yeon Seok Seo, Bora Keum, Hyung Joon Yim, Yoon Tae Jeen, Hong Sik Lee, Hoon Jai Chun, Chang Duck Kim, Ho Sang Ryu, Soon Ho Um

    Research output: Contribution to journalReview articlepeer-review

    6 Citations (Scopus)

    Abstract

    Porphyria cutanea tarda (PCT) is a metabolic disorder that results in a decrease in uroporphyrinogen decarboxylase activity. It is characterized by photosensitivity, bullae formation, and skin pigmentation. There are four types of PCT: acquired, familial, toxic, and hepatoerythropoietic. Uroporphyrin levels are elevated in the urine of PCT patients. PCT can be differentiated from other porphyrias by its clinical characteristics and the porphyrin levels in the serum, erythrocytes, urine, and feces. This metabolic disorder can lead to liver dysfunction as well as histological changes such as fatty infiltration or hepatic fibrosis. PCT rarely manifests as liver cirrhosis. We report herein a case of PCT-induced liver cirrhosis that progressed to hepatic failure.

    Original languageEnglish
    Pages (from-to)551-555
    Number of pages5
    JournalGut and liver
    Volume4
    Issue number4
    DOIs
    Publication statusPublished - 2010 Dec

    Keywords

    • Liver cirrhosis
    • Metabolic disorder
    • Porphyria cutanea tarda
    • Uroporphyrin

    ASJC Scopus subject areas

    • Hepatology
    • Gastroenterology

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