Liver enzymes and vitamin D levels in metabolically healthy but obese individuals: Korean National Health and Nutrition Examination Survey

Ho Cheol Hong, Ji Sung Lee, Hae Yoon Choi, Sae Jeong Yang, Hye-Jin Yoo, Ji A Seo, Sin Gon Kim, Nan Hee Kim, Sei-Hyun Baik, Dong Seop Choi, Kyung Mook Choi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Objective Increased liver enzymes and decreased vitamin D levels are associated with insulin resistance and type 2 diabetes. We examined liver enzymes and vitamin D levels in metabolically healthy but obese (MHO) individuals and compared the values with those of other body size phenotypes in the Korean population. Materials/Methods A total of 16,190 people over the age of 18 years were analyzed using data from the Fourth Korean National Health and Nutrition Examination Survey, which is a nationally representative survey. Body size phenotypes were classified into four groups by body mass index (BMI) and number of metabolic syndrome components. Results The prevalence of MHO was 14.9% in the entire population and 47.7% in the obese population. In a correlation analysis adjusted for age, sex, and BMI, AST and ALT levels were positively correlated with insulin resistance and cardiometabolic risk factors of the metabolic syndrome, whereas vitamin D level was negatively correlated with these variables. MHO individuals had significantly lower concentrations of AST and ALT compared to metabolically abnormal obese (MAO) subjects, although vitamin D levels were not significantly different. Furthermore, a multiple logistic regression analysis revealed that MHO individuals had lower risk of liver enzyme abnormality compared to MAO after adjusting for potential confounding factors. However, the risk of vitamin D deficiency was not significantly different among groups with different body size phenotypes. Conclusions Although both liver enzymes and vitamin D levels are related to insulin resistance and metabolic syndrome, only liver enzymes were independently associated with MHO phenotype.

Original languageEnglish
Pages (from-to)1305-1312
Number of pages8
JournalMetabolism: Clinical and Experimental
Volume62
Issue number9
DOIs
Publication statusPublished - 2013 Sep 1

Fingerprint

Nutrition Surveys
Vitamin D
Body Size
Liver
Phenotype
Enzymes
Insulin Resistance
Body Mass Index
Population
Vitamin D Deficiency
Type 2 Diabetes Mellitus
Logistic Models
Regression Analysis

Keywords

  • Body size phenotype
  • MHO
  • NAFLD
  • Obesity metabolism
  • Vitamin D

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Liver enzymes and vitamin D levels in metabolically healthy but obese individuals : Korean National Health and Nutrition Examination Survey. / Hong, Ho Cheol; Lee, Ji Sung; Choi, Hae Yoon; Yang, Sae Jeong; Yoo, Hye-Jin; Seo, Ji A; Kim, Sin Gon; Kim, Nan Hee; Baik, Sei-Hyun; Choi, Dong Seop; Choi, Kyung Mook.

In: Metabolism: Clinical and Experimental, Vol. 62, No. 9, 01.09.2013, p. 1305-1312.

Research output: Contribution to journalArticle

@article{edd13e9009e14be6ae83ebc4d925ff02,
title = "Liver enzymes and vitamin D levels in metabolically healthy but obese individuals: Korean National Health and Nutrition Examination Survey",
abstract = "Objective Increased liver enzymes and decreased vitamin D levels are associated with insulin resistance and type 2 diabetes. We examined liver enzymes and vitamin D levels in metabolically healthy but obese (MHO) individuals and compared the values with those of other body size phenotypes in the Korean population. Materials/Methods A total of 16,190 people over the age of 18 years were analyzed using data from the Fourth Korean National Health and Nutrition Examination Survey, which is a nationally representative survey. Body size phenotypes were classified into four groups by body mass index (BMI) and number of metabolic syndrome components. Results The prevalence of MHO was 14.9{\%} in the entire population and 47.7{\%} in the obese population. In a correlation analysis adjusted for age, sex, and BMI, AST and ALT levels were positively correlated with insulin resistance and cardiometabolic risk factors of the metabolic syndrome, whereas vitamin D level was negatively correlated with these variables. MHO individuals had significantly lower concentrations of AST and ALT compared to metabolically abnormal obese (MAO) subjects, although vitamin D levels were not significantly different. Furthermore, a multiple logistic regression analysis revealed that MHO individuals had lower risk of liver enzyme abnormality compared to MAO after adjusting for potential confounding factors. However, the risk of vitamin D deficiency was not significantly different among groups with different body size phenotypes. Conclusions Although both liver enzymes and vitamin D levels are related to insulin resistance and metabolic syndrome, only liver enzymes were independently associated with MHO phenotype.",
keywords = "Body size phenotype, MHO, NAFLD, Obesity metabolism, Vitamin D",
author = "Hong, {Ho Cheol} and Lee, {Ji Sung} and Choi, {Hae Yoon} and Yang, {Sae Jeong} and Hye-Jin Yoo and Seo, {Ji A} and Kim, {Sin Gon} and Kim, {Nan Hee} and Sei-Hyun Baik and Choi, {Dong Seop} and Choi, {Kyung Mook}",
year = "2013",
month = "9",
day = "1",
doi = "10.1016/j.metabol.2013.04.002",
language = "English",
volume = "62",
pages = "1305--1312",
journal = "Metabolism: Clinical and Experimental",
issn = "0026-0495",
publisher = "W.B. Saunders Ltd",
number = "9",

}

TY - JOUR

T1 - Liver enzymes and vitamin D levels in metabolically healthy but obese individuals

T2 - Korean National Health and Nutrition Examination Survey

AU - Hong, Ho Cheol

AU - Lee, Ji Sung

AU - Choi, Hae Yoon

AU - Yang, Sae Jeong

AU - Yoo, Hye-Jin

AU - Seo, Ji A

AU - Kim, Sin Gon

AU - Kim, Nan Hee

AU - Baik, Sei-Hyun

AU - Choi, Dong Seop

AU - Choi, Kyung Mook

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Objective Increased liver enzymes and decreased vitamin D levels are associated with insulin resistance and type 2 diabetes. We examined liver enzymes and vitamin D levels in metabolically healthy but obese (MHO) individuals and compared the values with those of other body size phenotypes in the Korean population. Materials/Methods A total of 16,190 people over the age of 18 years were analyzed using data from the Fourth Korean National Health and Nutrition Examination Survey, which is a nationally representative survey. Body size phenotypes were classified into four groups by body mass index (BMI) and number of metabolic syndrome components. Results The prevalence of MHO was 14.9% in the entire population and 47.7% in the obese population. In a correlation analysis adjusted for age, sex, and BMI, AST and ALT levels were positively correlated with insulin resistance and cardiometabolic risk factors of the metabolic syndrome, whereas vitamin D level was negatively correlated with these variables. MHO individuals had significantly lower concentrations of AST and ALT compared to metabolically abnormal obese (MAO) subjects, although vitamin D levels were not significantly different. Furthermore, a multiple logistic regression analysis revealed that MHO individuals had lower risk of liver enzyme abnormality compared to MAO after adjusting for potential confounding factors. However, the risk of vitamin D deficiency was not significantly different among groups with different body size phenotypes. Conclusions Although both liver enzymes and vitamin D levels are related to insulin resistance and metabolic syndrome, only liver enzymes were independently associated with MHO phenotype.

AB - Objective Increased liver enzymes and decreased vitamin D levels are associated with insulin resistance and type 2 diabetes. We examined liver enzymes and vitamin D levels in metabolically healthy but obese (MHO) individuals and compared the values with those of other body size phenotypes in the Korean population. Materials/Methods A total of 16,190 people over the age of 18 years were analyzed using data from the Fourth Korean National Health and Nutrition Examination Survey, which is a nationally representative survey. Body size phenotypes were classified into four groups by body mass index (BMI) and number of metabolic syndrome components. Results The prevalence of MHO was 14.9% in the entire population and 47.7% in the obese population. In a correlation analysis adjusted for age, sex, and BMI, AST and ALT levels were positively correlated with insulin resistance and cardiometabolic risk factors of the metabolic syndrome, whereas vitamin D level was negatively correlated with these variables. MHO individuals had significantly lower concentrations of AST and ALT compared to metabolically abnormal obese (MAO) subjects, although vitamin D levels were not significantly different. Furthermore, a multiple logistic regression analysis revealed that MHO individuals had lower risk of liver enzyme abnormality compared to MAO after adjusting for potential confounding factors. However, the risk of vitamin D deficiency was not significantly different among groups with different body size phenotypes. Conclusions Although both liver enzymes and vitamin D levels are related to insulin resistance and metabolic syndrome, only liver enzymes were independently associated with MHO phenotype.

KW - Body size phenotype

KW - MHO

KW - NAFLD

KW - Obesity metabolism

KW - Vitamin D

UR - http://www.scopus.com/inward/record.url?scp=84883146701&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883146701&partnerID=8YFLogxK

U2 - 10.1016/j.metabol.2013.04.002

DO - 10.1016/j.metabol.2013.04.002

M3 - Article

C2 - 23643404

AN - SCOPUS:84883146701

VL - 62

SP - 1305

EP - 1312

JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

SN - 0026-0495

IS - 9

ER -