Load-bearing capacity and biological allowable limit of biodegradable metal based on degradation rate in vivo

Sung Youn Cho, Soo Won Chae, Kui Won Choi, Hyun Kwang Seok, Hyung Seop Han, Seok Jo Yang, Young Yul Kim, Jong Tac Kim, Jae Young Jung, Michel Assad

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In this study, a newly developed Mg-Ca-Zn alloy for low degradation rate and surface erosion properties was evaluated. The compressive, tensile, and fatigue strength were measured before implantation. The degradation behavior was evaluated by analyzing the microstructure and local hardness of the explanted specimen. Mean and maximum degradation rates were measured using micro CT equipment from 4-, 8-, and 16- week explants, and the alloy was shown to display surface erosion properties. Based on these characteristics, the average and minimum load bearing capacities in tension, compression, and bending modes were calculated. According to the degradation rate and references of recommended dietary intakes (RDI), the Mg-Ca-Zn alloy appears to be safe for human use.

Original languageEnglish
Pages (from-to)1535-1544
Number of pages10
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume100 B
Issue number6
DOIs
Publication statusPublished - 2012 Aug 1

Keywords

  • biodegradable alloy
  • degradation rate
  • implant
  • load bearing
  • magnesium

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

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