Local duplication of gonadotropin-releasing hormone (GnRH) receptor before two rounds of whole genome duplication and origin of the mammalian GnRH receptor

Fatemeh Ameri Sefideh, Mi Jin Moon, Seongsik Yun, Sung In Hong, Jong-Ik Hwang, Jae Young Seong

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Gonadotropin-releasing hormone (GnRH) and the GnRH receptor (GnRHR) play an important role in vertebrate reproduction. Although many GnRHR genes have been identified in a large variety of vertebrate species, the evolutionary history of GnRHR in vertebrates is unclear. To trace the evolutionary origin of GnRHR we examined the conserved synteny of chromosomes harboring GnRHR genes and matched the genes to linkage groups of reconstructed vertebrate ancestor chromosomes. Consistent with the phylogenetic tree, three pairs of GnRHR subtypes were identified in three paralogous linkage groups, indicating that an ancestral pair emerged through local duplication before two rounds of whole genome duplication (2R). The 2R then led to the generation of six subtypes of GnRHR. Some subtypes were lost during vertebrate evolution after the divergence of teleosts and tetrapods. One subtype includes mammalian GnRHR and a coelacanth GnRHR that showed the greatest response to GnRH1 among the three types of GnRH. This study provides new insight into the evolutionary relationship of vertebrate GnRHRs.

Original languageEnglish
Article numbere87901
JournalPLoS One
Volume9
Issue number2
DOIs
Publication statusPublished - 2014 Feb 3

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LHRH Receptors
hormone receptors
gonadotropin-releasing hormone
Genes
Genome
receptors
genome
Vertebrates
vertebrates
linkage groups
Chromosomes
Gonadotropin-Releasing Hormone
chromosomes
Synteny
genes
ancestry
Reproduction
History
history
phylogeny

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Local duplication of gonadotropin-releasing hormone (GnRH) receptor before two rounds of whole genome duplication and origin of the mammalian GnRH receptor. / Sefideh, Fatemeh Ameri; Moon, Mi Jin; Yun, Seongsik; Hong, Sung In; Hwang, Jong-Ik; Seong, Jae Young.

In: PLoS One, Vol. 9, No. 2, e87901, 03.02.2014.

Research output: Contribution to journalArticle

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