Local neurokinin-1 receptor in the knee joint contributes to the induction, but not maintenance, of arthritic pain in the rat

Seung Kil Hong, Jeong Seok Han, Sun Seek Min, Jong Moon Hwang, Yang In Kim, Heung Sik Na, Young Wook Yoon, Hee Chul Han

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30 Citations (Scopus)


Substance P is known to exert various pro-inflammatory effects that are mediated by neurokinin-1 (NK-1) receptor in peripheral tissues. This study examined the effect of the NK-1 receptor antagonist cis-2-[diphenylmethyl]-N-[(2-iodophenyl)-1-azabicyclo[2.2.2]octan-3-amine] (L-703,606) on nociceptive response following carrageenan injection (2%, 50 μl) into the knee joint cavity of the right hind leg. L-703,606 injection (0.1 or 1 mM, 50 μl) into the same joint cavity immediately before the carrageenan injection significantly reduced the nociceptive response. However, antagonist treatment at 5 h after carrageenan injection was ineffective in alleviating nociception. Neither intraperitoneal injection of the antagonist (1 mM, 50 μl) immediately before the carrageenan injection was effective. These results suggest that local NK-1 receptor contributes to the induction, but not maintenance, of arthritic pain.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - 2002 Mar 29



  • Arthritis
  • Carrageenan
  • cis-2-[Diphenylmethyl]-N-[(2-iodophenyl)-1-azabicyclo[2.2.2]octan-3-amine]
  • Neurokinin-1
  • Substance P

ASJC Scopus subject areas

  • Neuroscience(all)

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