Abstract
Substance P is known to exert various pro-inflammatory effects that are mediated by neurokinin-1 (NK-1) receptor in peripheral tissues. This study examined the effect of the NK-1 receptor antagonist cis-2-[diphenylmethyl]-N-[(2-iodophenyl)-1-azabicyclo[2.2.2]octan-3-amine] (L-703,606) on nociceptive response following carrageenan injection (2%, 50 μl) into the knee joint cavity of the right hind leg. L-703,606 injection (0.1 or 1 mM, 50 μl) into the same joint cavity immediately before the carrageenan injection significantly reduced the nociceptive response. However, antagonist treatment at 5 h after carrageenan injection was ineffective in alleviating nociception. Neither intraperitoneal injection of the antagonist (1 mM, 50 μl) immediately before the carrageenan injection was effective. These results suggest that local NK-1 receptor contributes to the induction, but not maintenance, of arthritic pain.
| Original language | English |
|---|---|
| Pages (from-to) | 21-24 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 322 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2002 Mar 29 |
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Keywords
- Arthritis
- Carrageenan
- cis-2-[Diphenylmethyl]-N-[(2-iodophenyl)-1-azabicyclo[2.2.2]octan-3-amine]
- Neurokinin-1
- Substance P
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Local neurokinin-1 receptor in the knee joint contributes to the induction, but not maintenance, of arthritic pain in the rat. / Hong, Seung Kil; Han, Jeong Seok; Min, Sun Seek; Hwang, Jong Moon; Kim, Yang In; Na, Heung Sik; Yoon, Young Wook; Han, Hee Chul.
In: Neuroscience Letters, Vol. 322, No. 1, 29.03.2002, p. 21-24.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Local neurokinin-1 receptor in the knee joint contributes to the induction, but not maintenance, of arthritic pain in the rat
AU - Hong, Seung Kil
AU - Han, Jeong Seok
AU - Min, Sun Seek
AU - Hwang, Jong Moon
AU - Kim, Yang In
AU - Na, Heung Sik
AU - Yoon, Young Wook
AU - Han, Hee Chul
PY - 2002/3/29
Y1 - 2002/3/29
N2 - Substance P is known to exert various pro-inflammatory effects that are mediated by neurokinin-1 (NK-1) receptor in peripheral tissues. This study examined the effect of the NK-1 receptor antagonist cis-2-[diphenylmethyl]-N-[(2-iodophenyl)-1-azabicyclo[2.2.2]octan-3-amine] (L-703,606) on nociceptive response following carrageenan injection (2%, 50 μl) into the knee joint cavity of the right hind leg. L-703,606 injection (0.1 or 1 mM, 50 μl) into the same joint cavity immediately before the carrageenan injection significantly reduced the nociceptive response. However, antagonist treatment at 5 h after carrageenan injection was ineffective in alleviating nociception. Neither intraperitoneal injection of the antagonist (1 mM, 50 μl) immediately before the carrageenan injection was effective. These results suggest that local NK-1 receptor contributes to the induction, but not maintenance, of arthritic pain.
AB - Substance P is known to exert various pro-inflammatory effects that are mediated by neurokinin-1 (NK-1) receptor in peripheral tissues. This study examined the effect of the NK-1 receptor antagonist cis-2-[diphenylmethyl]-N-[(2-iodophenyl)-1-azabicyclo[2.2.2]octan-3-amine] (L-703,606) on nociceptive response following carrageenan injection (2%, 50 μl) into the knee joint cavity of the right hind leg. L-703,606 injection (0.1 or 1 mM, 50 μl) into the same joint cavity immediately before the carrageenan injection significantly reduced the nociceptive response. However, antagonist treatment at 5 h after carrageenan injection was ineffective in alleviating nociception. Neither intraperitoneal injection of the antagonist (1 mM, 50 μl) immediately before the carrageenan injection was effective. These results suggest that local NK-1 receptor contributes to the induction, but not maintenance, of arthritic pain.
KW - Arthritis
KW - Carrageenan
KW - cis-2-[Diphenylmethyl]-N-[(2-iodophenyl)-1-azabicyclo[2.2.2]octan-3-amine]
KW - Neurokinin-1
KW - Substance P
UR - http://www.scopus.com/inward/record.url?scp=0037192420&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037192420&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(02)00070-8
DO - 10.1016/S0304-3940(02)00070-8
M3 - Article
C2 - 11958834
AN - SCOPUS:0037192420
VL - 322
SP - 21
EP - 24
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1
ER -