Local neurokinin-1 receptor in the knee joint contributes to the induction, but not maintenance, of arthritic pain in the rat

Seung Kil Hong; Jeong Seok Han; Sun Seek Min; Jong Moon Hwang; Yang In Kim; Heung Sik Na; Young Wook Yoon; Hee Chul Han

doi:10.1016/S0304-3940(02)00070-8

Local neurokinin-1 receptor in the knee joint contributes to the induction, but not maintenance, of arthritic pain in the rat

Seung Kil Hong, Jeong Seok Han, Sun Seek Min, Jong Moon Hwang, Yang In Kim, Heung Sik Na, Young Wook Yoon, Hee Chul Han

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Substance P is known to exert various pro-inflammatory effects that are mediated by neurokinin-1 (NK-1) receptor in peripheral tissues. This study examined the effect of the NK-1 receptor antagonist cis-2-[diphenylmethyl]-N-[(2-iodophenyl)-1-azabicyclo[2.2.2]octan-3-amine] (L-703,606) on nociceptive response following carrageenan injection (2%, 50 μl) into the knee joint cavity of the right hind leg. L-703,606 injection (0.1 or 1 mM, 50 μl) into the same joint cavity immediately before the carrageenan injection significantly reduced the nociceptive response. However, antagonist treatment at 5 h after carrageenan injection was ineffective in alleviating nociception. Neither intraperitoneal injection of the antagonist (1 mM, 50 μl) immediately before the carrageenan injection was effective. These results suggest that local NK-1 receptor contributes to the induction, but not maintenance, of arthritic pain.

Original language	English
Pages (from-to)	21-24
Number of pages	4
Journal	Neuroscience Letters
Volume	322
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(02)00070-8
Publication status	Published - 2002 Mar 29

Keywords

Arthritis
Carrageenan
Neurokinin-1
Substance P
cis-2-[Diphenylmethyl]-N-[(2-iodophenyl)-1-azabicyclo[2.2.2]octan-3-amine]

ASJC Scopus subject areas

Neuroscience(all)

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Local neurokinin-1 receptor in the knee joint contributes to the induction, but not maintenance, of arthritic pain in the rat. / Hong, Seung Kil; Han, Jeong Seok; Min, Sun Seek; Hwang, Jong Moon; Kim, Yang In ; Na, Heung Sik ; Yoon, Young Wook ; Han, Hee Chul.

In: Neuroscience Letters, Vol. 322, No. 1, 29.03.2002, p. 21-24.

Research output: Contribution to journal › Article › peer-review

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title = "Local neurokinin-1 receptor in the knee joint contributes to the induction, but not maintenance, of arthritic pain in the rat",

abstract = "Substance P is known to exert various pro-inflammatory effects that are mediated by neurokinin-1 (NK-1) receptor in peripheral tissues. This study examined the effect of the NK-1 receptor antagonist cis-2-[diphenylmethyl]-N-[(2-iodophenyl)-1-azabicyclo[2.2.2]octan-3-amine] (L-703,606) on nociceptive response following carrageenan injection (2%, 50 μl) into the knee joint cavity of the right hind leg. L-703,606 injection (0.1 or 1 mM, 50 μl) into the same joint cavity immediately before the carrageenan injection significantly reduced the nociceptive response. However, antagonist treatment at 5 h after carrageenan injection was ineffective in alleviating nociception. Neither intraperitoneal injection of the antagonist (1 mM, 50 μl) immediately before the carrageenan injection was effective. These results suggest that local NK-1 receptor contributes to the induction, but not maintenance, of arthritic pain.",

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note = "Funding Information: This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (HMP-00-b-21300-0202) and the Brain Korea 21 Project in 2001. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

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AU - Yoon, Young Wook

AU - Han, Hee Chul

N1 - Funding Information: This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (HMP-00-b-21300-0202) and the Brain Korea 21 Project in 2001. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

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N2 - Substance P is known to exert various pro-inflammatory effects that are mediated by neurokinin-1 (NK-1) receptor in peripheral tissues. This study examined the effect of the NK-1 receptor antagonist cis-2-[diphenylmethyl]-N-[(2-iodophenyl)-1-azabicyclo[2.2.2]octan-3-amine] (L-703,606) on nociceptive response following carrageenan injection (2%, 50 μl) into the knee joint cavity of the right hind leg. L-703,606 injection (0.1 or 1 mM, 50 μl) into the same joint cavity immediately before the carrageenan injection significantly reduced the nociceptive response. However, antagonist treatment at 5 h after carrageenan injection was ineffective in alleviating nociception. Neither intraperitoneal injection of the antagonist (1 mM, 50 μl) immediately before the carrageenan injection was effective. These results suggest that local NK-1 receptor contributes to the induction, but not maintenance, of arthritic pain.

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Local neurokinin-1 receptor in the knee joint contributes to the induction, but not maintenance, of arthritic pain in the rat

Abstract

Keywords

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