Local recurrence after laparoscopic resection of T3 rectal cancer without preoperative chemoradiation and a risk group analysis: An Asian collaborative study

Sun Il Lee, Seon Hahn Kim, Hwei Ming Wang, Gyu Seog Choi, Min Hua Zheng, Masaki Fukunaga, Jun Gi Kim, Wai Lun Law, Joe Bin Chen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Risk factors for local recurrence and indication for preoperative radiation therapy have not been well evaluated for patients undergoing laparoscopic rectal cancer operation. From 1998 to 2004, 497 T3 rectal cancer patients with tumor located within 12 cm from the anal verge who had undergone laparoscopic surgery without preoperative radiation therapy by eight experienced laparoscopic surgeons in four Asian countries were reviewed retrospectively for the incidence of local recurrence and related factors. The median follow-up was 29.0 months (range, 6.0 to 92.3), and 31 cases of local recurrence were observed during the follow-up period (6 anastomosis site, 6 perineum, 17 pelvic wall, and 2 unclassified). The estimated local recurrence rates at 24 and 60 months were 5.42 and 9.41%, respectively. Patient's gender, tumor location, lymph node metastasis, and tumor perforation were independent factors for local recurrence by multivariate analysis. The local recurrence rate was comparable to previous studies using conventional open surgery with preoperative chemoradiation, except for a subgroup of male patients with the tumor located within 7 cm from the anal verge. The indication for preoperative radiation therapy would be different from those who will undergo conventional open surgery, and further evaluation of the benefits of preoperative radiation therapy is required for those with low risk tumor.

Original languageEnglish
Pages (from-to)933-938
Number of pages6
JournalJournal of Gastrointestinal Surgery
Volume12
Issue number5
DOIs
Publication statusPublished - 2008 May 1

Fingerprint

Rectal Neoplasms
Recurrence
Radiotherapy
Neoplasms
Perineum
Laparoscopy
Multivariate Analysis
Lymph Nodes
Neoplasm Metastasis
Incidence

Keywords

  • Laparoscopy
  • Local recurrence
  • T3 Rectal cancer

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

Cite this

Local recurrence after laparoscopic resection of T3 rectal cancer without preoperative chemoradiation and a risk group analysis : An Asian collaborative study. / Lee, Sun Il; Kim, Seon Hahn; Wang, Hwei Ming; Choi, Gyu Seog; Zheng, Min Hua; Fukunaga, Masaki; Kim, Jun Gi; Law, Wai Lun; Chen, Joe Bin.

In: Journal of Gastrointestinal Surgery, Vol. 12, No. 5, 01.05.2008, p. 933-938.

Research output: Contribution to journalArticle

Lee, Sun Il ; Kim, Seon Hahn ; Wang, Hwei Ming ; Choi, Gyu Seog ; Zheng, Min Hua ; Fukunaga, Masaki ; Kim, Jun Gi ; Law, Wai Lun ; Chen, Joe Bin. / Local recurrence after laparoscopic resection of T3 rectal cancer without preoperative chemoradiation and a risk group analysis : An Asian collaborative study. In: Journal of Gastrointestinal Surgery. 2008 ; Vol. 12, No. 5. pp. 933-938.
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