Locally transplanted human urine-induced nephron progenitor cells contribute to renal repair in mice kidney with diabetic nephropathy

Wei Wei Gao, So Young Chun, Bum Soo Kim, Yun Sok Ha, Jun Nyung Lee, Eun Hye Lee, In Yong Kim, Seungkwon You, Tae Gyun Kwon

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic Kidney Disease (CKD) is increasingly recognized as a global public health issue. Diabetic nephropathy (DN), also known as diabetic kidney disease, is a leading cause of CKD. Regenerative medicine strategy employing nephron progenitor cells (NPCs) is worthy of consideration as an alternative to shortage of donor organs for kidney transplantation. In previous study, we successfully generated induced NPCs (iNPCs) from human urine-derived cells that resembled human embryonic stem cell-derived NPCs. Here, we aimed to investigate the therapeutic potential of iNPCs in DN animal model. The results revealed the therapeutic effect of iNPCs as follows: (1) diminished glomerular hypertrophy, (2) reduced tubulointerstitial fibrosis, (3) low blood urea nitrogen, serum creatinine and albuminuria value, (4) decreased inflammation/fibrosis, (5) enhanced renal regeneration and (6) confirmed safety. This study demonstrates that human iNPCs have a therapeutic potential as a cell source for transplantation in patients with kidney diseases.

Original languageEnglish
Pages (from-to)128-134
Number of pages7
JournalBiochemical and biophysical research communications
Volume629
DOIs
Publication statusPublished - 2022 Nov 12

Keywords

  • Chronic kidney disease
  • Diabetic nephropathy
  • Induced nephron progenitor cells
  • Renal repair

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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