Long-Circulating Au-TiO2 Nanocomposite as a Sonosensitizer for ROS-Mediated Eradication of Cancer

V. G. Deepagan, Dong Gil You, Wooram Um, Hyewon Ko, Seunglee Kwon, Ki Young Choi, Gi Ra Yi, Jun Young Lee, Doo Sung Lee, Kwang Meyung Kim, Ick Chan Kwon, Jae Hyung Park

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Although sonodynamic therapy (SDT) has emerged as a potential alternative to conventional photodynamic therapy, the low quantum yield of the sonosensitizer such as TiO2 nanoparticles (NPs) is still a major concern. Here, we have developed hydrophilized Au-TiO2 nanocomposites (HAu-TiO2 NCs) as sonosensitizers for improved SDT. The physicochemical properties of HAu-TiO2 NCs were thoroughly studied and compared with their counterparts without gold deposition. Upon exposure of HAu-TiO2 NCs to ultrasound, a large quantity of reactive oxygen species (ROS) were generated, leading to complete suppression of tumor growth after their systemic administration in vivo. Overall, it was evident that the composites of gold with TiO2 NPs significantly augmented the levels of ROS generation, implying their potential as SDT agents for cancer therapy.

Original languageEnglish
Pages (from-to)6257-6264
Number of pages8
JournalNano Letters
Volume16
Issue number10
DOIs
Publication statusPublished - 2016 Oct 12
Externally publishedYes

Fingerprint

therapy
Reactive Oxygen Species
Nanocomposites
nanocomposites
cancer
Gold
Oxygen
oxygen
Nanoparticles
Photodynamic therapy
Quantum yield
Tumors
gold
Ultrasonics
nanoparticles
Composite materials
tumors
retarding
composite materials

Keywords

  • Au-TiO nanocomposite
  • enhanced sonodynamic therapy
  • prolonged circulation
  • ROS
  • ultrasound

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

Cite this

Deepagan, V. G., You, D. G., Um, W., Ko, H., Kwon, S., Choi, K. Y., ... Park, J. H. (2016). Long-Circulating Au-TiO2 Nanocomposite as a Sonosensitizer for ROS-Mediated Eradication of Cancer. Nano Letters, 16(10), 6257-6264. https://doi.org/10.1021/acs.nanolett.6b02547

Long-Circulating Au-TiO2 Nanocomposite as a Sonosensitizer for ROS-Mediated Eradication of Cancer. / Deepagan, V. G.; You, Dong Gil; Um, Wooram; Ko, Hyewon; Kwon, Seunglee; Choi, Ki Young; Yi, Gi Ra; Lee, Jun Young; Lee, Doo Sung; Kim, Kwang Meyung; Kwon, Ick Chan; Park, Jae Hyung.

In: Nano Letters, Vol. 16, No. 10, 12.10.2016, p. 6257-6264.

Research output: Contribution to journalArticle

Deepagan, VG, You, DG, Um, W, Ko, H, Kwon, S, Choi, KY, Yi, GR, Lee, JY, Lee, DS, Kim, KM, Kwon, IC & Park, JH 2016, 'Long-Circulating Au-TiO2 Nanocomposite as a Sonosensitizer for ROS-Mediated Eradication of Cancer', Nano Letters, vol. 16, no. 10, pp. 6257-6264. https://doi.org/10.1021/acs.nanolett.6b02547
Deepagan, V. G. ; You, Dong Gil ; Um, Wooram ; Ko, Hyewon ; Kwon, Seunglee ; Choi, Ki Young ; Yi, Gi Ra ; Lee, Jun Young ; Lee, Doo Sung ; Kim, Kwang Meyung ; Kwon, Ick Chan ; Park, Jae Hyung. / Long-Circulating Au-TiO2 Nanocomposite as a Sonosensitizer for ROS-Mediated Eradication of Cancer. In: Nano Letters. 2016 ; Vol. 16, No. 10. pp. 6257-6264.
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