Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration

Néstor J. Oviedo, Junji Morokuma, Peter Walentek, Ido P. Kema, Man Bock Gu, Joo Myung Ahn, Jung Shan Hwang, Takashi Gojobori, Michael Levin

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Having the ability to coordinate the behavior of stem cells to induce regeneration of specific large-scale structures would have far-reaching consequences in the treatment of degenerative diseases, acute injury, and aging. Thus, identifying and learning to manipulate the sequential steps that determine the fate of new tissue within the overall morphogenetic program of the organism is fundamental. We identified novel early signals, mediated by the central nervous system and 3 innexin proteins, which determine the fate and axial polarity of regenerated tissue in planarians. Modulation of gap junction-dependent and neural signals specifically induces ectopic anterior regeneration blastemas in posterior and lateral wounds. These ectopic anterior blastemas differentiate new brains that establish permanent primary axes re-established during subsequent rounds of unperturbed regeneration. These data reveal powerful novel controls of pattern formation and suggest a constructive model linking nervous inputs and polarity determination in early stages of regeneration.

Original languageEnglish
Pages (from-to)188-199
Number of pages12
JournalDevelopmental Biology
Volume339
Issue number1
DOIs
Publication statusPublished - 2010 Mar 1

Fingerprint

Planarians
Connexins
Cues
Regeneration
Aptitude
Gap Junctions
Wounds and Injuries
Acute Disease
Stem Cells
Central Nervous System
Learning
Brain
Proteins

Keywords

  • Gap junctions
  • Neural signals
  • Planaria
  • Polarity
  • Regeneration

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology
  • Molecular Biology

Cite this

Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration. / Oviedo, Néstor J.; Morokuma, Junji; Walentek, Peter; Kema, Ido P.; Gu, Man Bock; Ahn, Joo Myung; Hwang, Jung Shan; Gojobori, Takashi; Levin, Michael.

In: Developmental Biology, Vol. 339, No. 1, 01.03.2010, p. 188-199.

Research output: Contribution to journalArticle

Oviedo, NJ, Morokuma, J, Walentek, P, Kema, IP, Gu, MB, Ahn, JM, Hwang, JS, Gojobori, T & Levin, M 2010, 'Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration', Developmental Biology, vol. 339, no. 1, pp. 188-199. https://doi.org/10.1016/j.ydbio.2009.12.012
Oviedo, Néstor J. ; Morokuma, Junji ; Walentek, Peter ; Kema, Ido P. ; Gu, Man Bock ; Ahn, Joo Myung ; Hwang, Jung Shan ; Gojobori, Takashi ; Levin, Michael. / Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration. In: Developmental Biology. 2010 ; Vol. 339, No. 1. pp. 188-199.
@article{b36547d14b38414b8af9eb06ca1b77d3,
title = "Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration",
abstract = "Having the ability to coordinate the behavior of stem cells to induce regeneration of specific large-scale structures would have far-reaching consequences in the treatment of degenerative diseases, acute injury, and aging. Thus, identifying and learning to manipulate the sequential steps that determine the fate of new tissue within the overall morphogenetic program of the organism is fundamental. We identified novel early signals, mediated by the central nervous system and 3 innexin proteins, which determine the fate and axial polarity of regenerated tissue in planarians. Modulation of gap junction-dependent and neural signals specifically induces ectopic anterior regeneration blastemas in posterior and lateral wounds. These ectopic anterior blastemas differentiate new brains that establish permanent primary axes re-established during subsequent rounds of unperturbed regeneration. These data reveal powerful novel controls of pattern formation and suggest a constructive model linking nervous inputs and polarity determination in early stages of regeneration.",
keywords = "Gap junctions, Neural signals, Planaria, Polarity, Regeneration",
author = "Oviedo, {N{\'e}stor J.} and Junji Morokuma and Peter Walentek and Kema, {Ido P.} and Gu, {Man Bock} and Ahn, {Joo Myung} and Hwang, {Jung Shan} and Takashi Gojobori and Michael Levin",
year = "2010",
month = "3",
day = "1",
doi = "10.1016/j.ydbio.2009.12.012",
language = "English",
volume = "339",
pages = "188--199",
journal = "Developmental Biology",
issn = "0012-1606",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration

AU - Oviedo, Néstor J.

AU - Morokuma, Junji

AU - Walentek, Peter

AU - Kema, Ido P.

AU - Gu, Man Bock

AU - Ahn, Joo Myung

AU - Hwang, Jung Shan

AU - Gojobori, Takashi

AU - Levin, Michael

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Having the ability to coordinate the behavior of stem cells to induce regeneration of specific large-scale structures would have far-reaching consequences in the treatment of degenerative diseases, acute injury, and aging. Thus, identifying and learning to manipulate the sequential steps that determine the fate of new tissue within the overall morphogenetic program of the organism is fundamental. We identified novel early signals, mediated by the central nervous system and 3 innexin proteins, which determine the fate and axial polarity of regenerated tissue in planarians. Modulation of gap junction-dependent and neural signals specifically induces ectopic anterior regeneration blastemas in posterior and lateral wounds. These ectopic anterior blastemas differentiate new brains that establish permanent primary axes re-established during subsequent rounds of unperturbed regeneration. These data reveal powerful novel controls of pattern formation and suggest a constructive model linking nervous inputs and polarity determination in early stages of regeneration.

AB - Having the ability to coordinate the behavior of stem cells to induce regeneration of specific large-scale structures would have far-reaching consequences in the treatment of degenerative diseases, acute injury, and aging. Thus, identifying and learning to manipulate the sequential steps that determine the fate of new tissue within the overall morphogenetic program of the organism is fundamental. We identified novel early signals, mediated by the central nervous system and 3 innexin proteins, which determine the fate and axial polarity of regenerated tissue in planarians. Modulation of gap junction-dependent and neural signals specifically induces ectopic anterior regeneration blastemas in posterior and lateral wounds. These ectopic anterior blastemas differentiate new brains that establish permanent primary axes re-established during subsequent rounds of unperturbed regeneration. These data reveal powerful novel controls of pattern formation and suggest a constructive model linking nervous inputs and polarity determination in early stages of regeneration.

KW - Gap junctions

KW - Neural signals

KW - Planaria

KW - Polarity

KW - Regeneration

UR - http://www.scopus.com/inward/record.url?scp=77649181185&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77649181185&partnerID=8YFLogxK

U2 - 10.1016/j.ydbio.2009.12.012

DO - 10.1016/j.ydbio.2009.12.012

M3 - Article

C2 - 20026026

AN - SCOPUS:77649181185

VL - 339

SP - 188

EP - 199

JO - Developmental Biology

JF - Developmental Biology

SN - 0012-1606

IS - 1

ER -