Abstract
Background In the Effects of Postconditioning on Myocardial Reperfusion in Patients with ST-segment Elevation Myocardial Infarction (POST) trial, ischemic postconditioning failed to improve myocardial reperfusion. However, long-term effects of ischemic postconditioning on clinical outcomes are not known in patients with ST-segment elevation myocardial infarction. Methods A total of 700 patients undergoing primary percutaneous coronary intervention (PCI) were randomly assigned to the postconditioning group or the conventional primary PCI group in a 1:1 ratio. Postconditioning was performed immediately after restoration of coronary flow by balloon occlusion 4 times for 1 minute. Complete follow-up data for major clinical events at 1 year were available in 695 patients (99.3%), and analyses were done by the intention to treat principle. The primary outcome was a composite of death, myocardial infarction, severe heart failure, or stent thrombosis at 1 year. Results At 1 year, a composite of death, myocardial infarction, severe heart failure, or stent thrombosis occurred in 21 patients (6.1%) in the postconditioning group and 16 patients (4.6%) in the conventional PCI group (hazard ratio [HR] 1.32, 95% CI 0.69-2.53, P =.40). The risk of death (4.9% vs 3.7%, HR 1.32, 95% CI 0.64-2.71, P =.46), heart failure (2.6% vs 2.3%, HR 1.13, 95% CI 0.44-2.94, P =.80), and stent thrombosis (2.3% vs 1.7%, HR 1.34, 95% CI 0.46-3.85, P =.59) did not differ significantly between the 2 groups. Conclusions Ischemic postconditioning does not seem to improve the 1-year clinical outcomes in patients with ST-segment elevation myocardial infarction undergoing primary PCI.
| Original language | English |
|---|---|
| Pages (from-to) | 639-646 |
| Number of pages | 8 |
| Journal | American Heart Journal |
| Volume | 169 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2015 May 1 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Long-term effects of ischemic postconditioning on clinical outcomes : 1-year follow-up of the POST randomized trial. / Hahn, Joo Yong; Yu, Cheol Woong; Park, Hun Sik; Song, Young Bin; Kim, Eun Kyoung; Lee, Hyun Jong; Bae, Jang Whan; Chung, Woo Young; Choi, Seung Hyuk; Choi, Jin Ho; Bae, Jang Ho; An, Kyung Joo; Park, Jong Seon; Oh, Ju Hyeon; Kim, Sang Wook; Hwang, Jin Yong; Ryu, Jae Kean; Lim, Do-Sun; Gwon, Hyeon Cheol.
In: American Heart Journal, Vol. 169, No. 5, 01.05.2015, p. 639-646.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term effects of ischemic postconditioning on clinical outcomes
T2 - 1-year follow-up of the POST randomized trial
AU - Hahn, Joo Yong
AU - Yu, Cheol Woong
AU - Park, Hun Sik
AU - Song, Young Bin
AU - Kim, Eun Kyoung
AU - Lee, Hyun Jong
AU - Bae, Jang Whan
AU - Chung, Woo Young
AU - Choi, Seung Hyuk
AU - Choi, Jin Ho
AU - Bae, Jang Ho
AU - An, Kyung Joo
AU - Park, Jong Seon
AU - Oh, Ju Hyeon
AU - Kim, Sang Wook
AU - Hwang, Jin Yong
AU - Ryu, Jae Kean
AU - Lim, Do-Sun
AU - Gwon, Hyeon Cheol
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Background In the Effects of Postconditioning on Myocardial Reperfusion in Patients with ST-segment Elevation Myocardial Infarction (POST) trial, ischemic postconditioning failed to improve myocardial reperfusion. However, long-term effects of ischemic postconditioning on clinical outcomes are not known in patients with ST-segment elevation myocardial infarction. Methods A total of 700 patients undergoing primary percutaneous coronary intervention (PCI) were randomly assigned to the postconditioning group or the conventional primary PCI group in a 1:1 ratio. Postconditioning was performed immediately after restoration of coronary flow by balloon occlusion 4 times for 1 minute. Complete follow-up data for major clinical events at 1 year were available in 695 patients (99.3%), and analyses were done by the intention to treat principle. The primary outcome was a composite of death, myocardial infarction, severe heart failure, or stent thrombosis at 1 year. Results At 1 year, a composite of death, myocardial infarction, severe heart failure, or stent thrombosis occurred in 21 patients (6.1%) in the postconditioning group and 16 patients (4.6%) in the conventional PCI group (hazard ratio [HR] 1.32, 95% CI 0.69-2.53, P =.40). The risk of death (4.9% vs 3.7%, HR 1.32, 95% CI 0.64-2.71, P =.46), heart failure (2.6% vs 2.3%, HR 1.13, 95% CI 0.44-2.94, P =.80), and stent thrombosis (2.3% vs 1.7%, HR 1.34, 95% CI 0.46-3.85, P =.59) did not differ significantly between the 2 groups. Conclusions Ischemic postconditioning does not seem to improve the 1-year clinical outcomes in patients with ST-segment elevation myocardial infarction undergoing primary PCI.
AB - Background In the Effects of Postconditioning on Myocardial Reperfusion in Patients with ST-segment Elevation Myocardial Infarction (POST) trial, ischemic postconditioning failed to improve myocardial reperfusion. However, long-term effects of ischemic postconditioning on clinical outcomes are not known in patients with ST-segment elevation myocardial infarction. Methods A total of 700 patients undergoing primary percutaneous coronary intervention (PCI) were randomly assigned to the postconditioning group or the conventional primary PCI group in a 1:1 ratio. Postconditioning was performed immediately after restoration of coronary flow by balloon occlusion 4 times for 1 minute. Complete follow-up data for major clinical events at 1 year were available in 695 patients (99.3%), and analyses were done by the intention to treat principle. The primary outcome was a composite of death, myocardial infarction, severe heart failure, or stent thrombosis at 1 year. Results At 1 year, a composite of death, myocardial infarction, severe heart failure, or stent thrombosis occurred in 21 patients (6.1%) in the postconditioning group and 16 patients (4.6%) in the conventional PCI group (hazard ratio [HR] 1.32, 95% CI 0.69-2.53, P =.40). The risk of death (4.9% vs 3.7%, HR 1.32, 95% CI 0.64-2.71, P =.46), heart failure (2.6% vs 2.3%, HR 1.13, 95% CI 0.44-2.94, P =.80), and stent thrombosis (2.3% vs 1.7%, HR 1.34, 95% CI 0.46-3.85, P =.59) did not differ significantly between the 2 groups. Conclusions Ischemic postconditioning does not seem to improve the 1-year clinical outcomes in patients with ST-segment elevation myocardial infarction undergoing primary PCI.
UR - http://www.scopus.com/inward/record.url?scp=84929262060&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929262060&partnerID=8YFLogxK
U2 - 10.1016/j.ahj.2015.01.015
DO - 10.1016/j.ahj.2015.01.015
M3 - Article
C2 - 25965711
AN - SCOPUS:84929262060
VL - 169
SP - 639
EP - 646
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 5
ER -